A mediocre bioinformatics & coding geek in City of Hope/ Proud member of the Chair of Molecular and Cellular Endocrinology Dr. Garcia-Ocana Lab
California
Joined June 2010
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Finally, long-waited paper was published and available online. Thanks a lot for @Brian74534732 and my PI AGO, and everyone who were involved in this project at @AGOcanaLab_COH for guiding and supporting this whole project.
nature.com/articles/s41467-0…
Randy Kang retweeted
Drum rolls for our top post of 2025! 🥁
Through human pancreatic α-cell heterogeneity and trajectory inference analyses, Randy Kang (@randystyle) and team uncovered SMOC1 as a β-cell dedifferentiation gene.
nitter.cf/PancreaticCell/status/…
🥼 Randy Kang and scientists at @cityofhope used single-cell and single-nucleus RNA-seq, RNA velocity, PAGA/cell trajectory inference, and gene commonality, interrogating α-β-cell fate switching in human islets.
@NatureComms | go.nature.com/42xumA3
Randy Kang retweeted
This new paper on diabetes marker genes just came out online! You might find it interesting: nature.com/articles/s41467-0…
Randy Kang retweeted
🥼 Randy Kang and scientists at @cityofhope used single-cell and single-nucleus RNA-seq, RNA velocity, PAGA/cell trajectory inference, and gene commonality, interrogating α-β-cell fate switching in human islets.
@NatureComms | go.nature.com/42xumA3
Randy Kang retweeted
Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene.
nature.com/articles/s41467-0…
Randy Kang retweeted
5. Experimentally increasing SMOC1 in human β-cells reduces insulin expression & secretion, impairs β-cell identity, and induces α-cell–like features.
6. A possible feedback loop is suggested: T2D stress → FOXO1 up → SMOC1 up → worsening β-cell dysfunctional.
Randy Kang retweeted
1. Using single-cell & single-nucleus RNA sequencing, the we defined five α-cell subtypes in human pancreatic islets.
2. In healthy islets, we modeled cell to cell transition using deep learning, and found out trajectories between α- and β-cells appear bidirectional.
Randy Kang retweeted
Finally, long-waited paper was published and available online. Thanks a lot for @Brian74534732 and my PI AGO, and everyone who were involved in this project at @AGOcanaLab_COH for guiding and supporting this whole project.
nature.com/articles/s41467-0…
Randy Kang retweeted
3. In type 2 diabetes (T2D), trajectories favor a one-way transition from β → α, consistent with β-cell dedifferentiation.
4. Among genes implicated in this β→α shift, SMOC1 stands out: it is normally α-cell–selective but is upregulated in β-cells in T2D.
3. In type 2 diabetes (T2D), trajectories favor a one-way transition from β → α, consistent with β-cell dedifferentiation.
4. Among genes implicated in this β→α shift, SMOC1 stands out: it is normally α-cell–selective but is upregulated in β-cells in T2D.
Randy Kang retweeted
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes.
nejm.org/doi/full/10.1056/NE…
Randy Kang retweeted
Excited to share our latest findings today at 2 PM!
We uncover how mitophagy regulates β-cell identity and immunogenicity in T1D.
Looking forward to great discussions on diabetes research—see you there!
Randy Kang retweeted
Our new preprint presents 3D light-sheet imaging of the intact islet, focusing on β-cell subpopulations that lead and coordinate islet Ca2+ oscillations. Great collaboration between Erli Jin, @JenniferKBriggs, and @BennyScience . biorxiv.org/content/10.1101/…
STM article from our lab is finally out!!
science.org/doi/10.1126/scit…
Randy Kang retweeted
Our lab is recruiting for three (!) postdoc positions:
1. First is a joint postdoc with @pdhsu to work on v cool (imo) syn bio projects bridging molecular & genome scales. Those with experience in either experimental syn bio or in ML (or both!) are welcome to apply! 1/n
Please RT! @BrianHie and I are hiring joint @arcinstitute postdocs to work on ML in biology. Projects include reimagining synthetic gene circuits, mechanistic interpretability, and controllability. Recent work includes genome design with Evo, an AI foundation model trained on DNA to learn the language of evolution
patrick[]arcinstitute.org
brianhie[]stanford.edu
Randy Kang retweeted
I am honored to talk about one of my projects at the ADA 2024 on Sunday at 3:45 PM! I look forward to seeing you all and hearing your comments.
Randy Kang retweeted
The PI's contribution to the paper nitter.cf/PamelaWelt/status/1786…