Ryuta Koyama (@ryuta_koyama) header
Ryuta Koyama (@ryuta_koyama) profile picture

Ryuta Koyama

@ryuta_koyama

Neuroscientist studying neuron-glia interaction. Director at Department of Translational Neurobiology, National Institute of Neuroscience, NCNP, Japan.

 Tokyo, Japan
ncnp.go.jp/nin/guide/r2/en/index.html
Joined June 2017
  • Tweets1.4K
  • Following200
  • Followers510
1Media
Photo by Ryuta Koyama (@ryuta_koyama)
Alzheimer’s disease genetics converges on microglial and neuronal dysregulation nature.com/articles/s41586-0…
Alzheimer’s disease genetics converges on microglial and neuronal dysregulation

Alzheimer’s disease genetics converges on microglial and neuronal dysregulation

Nature - A multi-ancestry study of Alzheimer’s disease identifies new risk loci and potential drug targets, implicates microglia and neurons, and reveals a larger common-variant contribution...

nature.com
3
15
964
Glioma regulates GABAergic signaling to drive hyperactivity and tumor progression: Neuron cell.com/neuron/fulltext/S08…
Glioma regulates GABAergic signaling to drive hyperactivity and tumor progression

Glioma regulates GABAergic signaling to drive hyperactivity and tumor progression

We find that knockout of the GABA transporter Slc6a1 facilitates glioma growth with decreased tumoral GABA release. Activity of inhibitory neurons affects glioma proliferation, which can be altered...

cell.com
4
11
1,029
Ryuta Koyama retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggonerOct 28
Replying to @biorxivpreprint
@biorxivpreprint Lysosomal adaptation to extracellular acidity compromises CD8+ T cell cytotoxicity biorxiv.org/content/10.64898… @at_Mitralab @univ_lille @inserm
Image from Waggoner Lab (@LabWaggoner)
5
26
1,682
Ryuta Koyama retweeted
John Lukens (@LukensJohnR) profile picture
John Lukens
@LukensJohnROct 27
New study from our group @Addie_E_Walsh 👇 Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis @JExpMed rupress.org/jem/article/223/… #Alzheimer
Image from John Lukens (@LukensJohnR)
2
29
68
2,312
Ryuta Koyama retweeted
John Lukens (@LukensJohnR) profile picture
John Lukens
@LukensJohnROct 27
Translational control of microglial metabolism, inflammatory responses, and survival by the eIF4E-binding proteins | PNAS pnas.org/doi/abs/10.1073/pna…
Translational control of microglial metabolism, inflammatory responses, and survival by the...

Translational control of microglial metabolism, inflammatory responses, and survival by the...

In Alzheimer’s disease (AD), activation of the mechanistic target of rapamycin (mTOR) pathway promotes microglial neuroprotective functions by enga...

pnas.org
13
40
1,590
Ryuta Koyama retweeted
Ali Max Erturk (@erturklab) profile picture
Ali Max Erturk
@erturklabOct 26
Now in the October issue of @NatureProtocols: our wildDISCO protocol 🔬 Whole-body immunolabeling, DISCO clearing and 3D imaging of entire mice at cellular resolution with standard IgG antibodies, ~4 weeks start to finish. Whole-mouse innervation 👇🏻 doi.org/10.1038/s41596-026-0…
Image from Ali Max Erturk (@erturklab)
1
27
3
115
6,554
Cytokine circuits in CNS homeostasis and disease nature.com/articles/s41590-0…
Cytokine circuits in CNS homeostasis and disease

Cytokine circuits in CNS homeostasis and disease

Nature Immunology - In their Review, Becher et al. discuss how selected cytokine networks preserve, destabilize and restore central nervous system integrity.

nature.com
7
23
1,344
The maternal–fetal interface is an early hematopoietic niche enriched in distinct erythro-myeloid progenitors nature.com/articles/s41590-0…
The maternal–fetal interface is an early hematopoietic niche enriched in distinct erythro-myeloid...

The maternal–fetal interface is an early hematopoietic niche enriched in distinct erythro-myeloid...

Nature Immunology - Jain et al. identify a unique extraembryonic hematopoietic niche at the maternal–fetal interface that is distinct from the yolk sac and is capable of producing...

nature.com
1
3
181
AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact. From Benjamin S. Padman, Runa S.J. Lindblom, and Michael Lazarou: hubs.la/Q04B2lfC0 📕 Part of our #Tools collection: hubs.la/Q04B2lsp0
Image from Journal of Cell Biology (@JCellBiol)
4
24
1,882
Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells nature.com/articles/s41589-0…
Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells

Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells

Nature Chemical Biology - The chemogenetic tool Grubraw activates mitochondria by generating pyruvate in the mitochondrial matrix. This triggers a genetic switch that slows down tumor cell...

nature.com
3
380
GRP75-dependent SIMPA mediates inter-organellar quality control nature.com/articles/s41586-0…
GRP75-dependent SIMPA mediates inter-organellar quality control

GRP75-dependent SIMPA mediates inter-organellar quality control

Nature - Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling...

nature.com
125
Identification of candidate markers for the isolation of neuron-specific extracellular vesicles nature.com/articles/s41593-0…
Identification of candidate markers for the isolation of neuron-specific extracellular vesicles

Identification of candidate markers for the isolation of neuron-specific extracellular vesicles

Nature Neuroscience - The authors developed methods to identify extracellular vesicles (EVs) in the blood that come from the brain by capturing EV surface proteins. This could be used in the future...

nature.com
1
11
1,020
Ryuta Koyama retweeted
Immunity (@ImmunityCP) profile picture
Immunity@ImmunityCPOct 26
Online now: Human brain cellular xenografts in neuroimmunology and beyond dlvr.​it/TW4233
Image from Immunity (@ImmunityCP)
3
10
2,014
Chronic progressive demyelination induces a microglial state with lysosomal dysfunction nature.com/articles/s41593-0…
Chronic progressive demyelination induces a microglial state with lysosomal dysfunction

Chronic progressive demyelination induces a microglial state with lysosomal dysfunction

Nature Neuroscience - Acute myelin injury responses are well defined, but microglia adaptations to chronic damage remain unclear. Mouse models reveal a chronic demyelination-associated microglial...

nature.com
5
6
669
Dynamic roles of embryonic glial cells in octopus brain development: Current Biology cell.com/current-biology/ful…
Dynamic roles of embryonic glial cells in octopus brain development

Dynamic roles of embryonic glial cells in octopus brain development

Here, Lassnig et al. document a previously undiscovered embryonic glial cell population in Octopus vulgaris and describe their dynamic and organizing roles in brain development. Comparisons with...

cell.com
2
8
811
biorxiv.org/content/10.64898…
Brain-Resident CD8+ T Cells Regulate Neuronal Activity and Behavior via Interferon-Gamma

Brain-Resident CD8+ T Cells Regulate Neuronal Activity and Behavior via Interferon-Gamma

Maintaining brain homeostasis is crucial for proper function of the central nervous system and has traditionally been attributed to neuronal and glial interactions. However, recent research highlig...

biorxiv.org
2
5
1,840
Mitochondria-ER-lipid droplet crosstalk regulates metabolic adaptation to shear stress via VMP1: Current Biology cell.com/current-biology/ful…
Mitochondria-ER-lipid droplet crosstalk regulates metabolic adaptation to shear stress via VMP1

Mitochondria-ER-lipid droplet crosstalk regulates metabolic adaptation to shear stress via VMP1

Rojas et al. show that physiological shear stress triggers rapid mitochondrial remodeling and transient stabilization of ER-mitochondria contact sites in kidney epithelial cells. These contacts...

cell.com
1
1
178
TIA1 is required for microglial activation in tauopathy: Cell Reports cell.com/cell-reports/fullte…
TIA1 is required for microglial activation in tauopathy

TIA1 is required for microglial activation in tauopathy

Webber et al. find that the RNA-binding protein TIA1 promotes microglial activation and tau pathology in a mouse model of tauopathy. This study also shows opposing regulatory roles of TIA1 in central...

cell.com
1
218
New online! Mitochondrial dysfunction in neurology: biomarkers and clinical implications dlvr.​it/TW2G4k
Image from Nat Rev Neurology (@NatRevNeurol)
1
7
28
2,515
Revisiting the macrophage disappearance reaction: Trends in Immunology cell.com/trends/immunology/f…
Revisiting the macrophage disappearance reaction

Revisiting the macrophage disappearance reaction

The macrophage disappearance reaction (MDR) was originally proposed to explain the loss of peritoneal macrophages in inflammation but has since been extended across tissues and diseases. MDR involves...

cell.com
1
1
247
Load more