Bioinformatics/Biostatistics Researcher @simon_anders@mstdn.social
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ALT Beeswarm plot of the double perturbation predictions. The Additive model outperforms GEARS, scGPT, and scFoundation by a large margin
ALT Line plot of the accuracy of the predictions that are most different from the additive model. The No Change model outperforms GEARS, scGPT, and scFoundation.
ALT Beeswarm plot of the single perturbation predictions. The linear model perform as good as GEARS, scGPT, and scFoundation.
ALT Beeswarm plot of the double perturbation predictions. The Additive model outperforms GEARS, scGPT, and scFoundation by a large margin
ALT Line plot of the accuracy of the predictions that are most different from the additive model. The No Change model outperforms GEARS, scGPT, and scFoundation.
ALT Beeswarm plot of the single perturbation predictions. The linear model perform as good as GEARS, scGPT, and scFoundation.
ALT Top: Schematic depiction of genes involved in astrocyte function and neurogenesis, and their methylation and gene expression status in different cell states. Bottom: We propose that DNA methylation locks common parenchymal astrocytes in their astrocyte fate by repressing genes required for neurogenesis. By contrast, these genes are demethylated in NSCs, which permits their progression along the neurogenic lineage.
