Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂
London, England
Joined January 2016
- Tweets25.8K
- Following248
- Followers11.3K
- Likes9.9K
The Science of Parkinson's retweeted
Less than 5% of people with Parkinson’s are taking part in clinical research studies. Let’s change that. We’re calling on MPs to declare “I support Cure Parkinson’s campaign to empower more people living with Parkinson’s to take part in research.” Join us: buff.ly/mzLk6Nu
New research finds wearable-measures of dyskinesia, but not clinician-rated dyskinesia, independently predicted poorer sleep, supporting wearable monitoring in #Parkinsons; Small study (n=47)
movementdisorders.onlinelibr…
Researchers report that thrombin, a serine protease associated with inflammatory conditions, selectively cleaves #Parkinsons-associated α-Synuclein at Lys6–Gly7, generating a 7–140 fragment despite the presence of multiple potential cleavage sites
nature.com/articles/s41467-0…
A multimodal neuroimaging study analyzing neuromelanin & iron brainstem content in #Parkinsons identify nigrosome-1 as the main subregion where multimodal MRI captures the PD-related nigral degeneration; iPD & GBA1-PD difference
nature.com/articles/s41531-0…
Using longitudinal blood-based proteomics from 166 patients, researchers propose progression-specific molecular signatures in #Parkinsons; Higher CD276 & POSTN associated with worse MDS-UPDRS2, while higher VEGF-C & IL19 associated with worse MDS-UPDRS3
nature.com/articles/s41531-0…
Researchers identify adenosine deaminase 2 (ADA2) as a key regulator of mitochondrial quality control that prevents organelle dysfunction & limits inflammation driven by aberrant IFN signaling
nature.com/articles/s41418-0…
Results of a randomized crossover trial comparing 8-week Mediterranean-ketogenic vs medium-chain triglyceride-supplemented Mediterranean diets in 52 people with #Parkinsons (NCT05469997) finds neither approach markedly alters the gut microbiome
cell.com/iscience/fulltext/S…
Researchers map the age-dependent structural landscape of Orb2 amyloid (a synaptic translation regulator required for long-term memory) across the adult lifespan of Drosophila melanogaster & uncover a dynamic, age-linked progression of amyloid states
cell.com/cell/abstract/S0092…
The Science of Parkinson's retweeted
On Monday 16 November, Cure Parkinson's and France Parkinson are hosting an in-person and online public conference exploring how platform trials could accelerate the search for treatments that slow, stop or reverse Parkinson's.
Book your place: buff.ly/EhSah8K
ALT Hybrid conference on innovative ways to slow, stop or reverse Parkinson’s — "The promise of platform trials," hosted by GAPP on Monday 16 November, 2–5pm GMT; book in-person or online at cureparkinsons.org.uk/paris-gapp; powered by France Parkinson and Cure Parkinson’s.
New data indicate that speech-in-noise deficits in #Parkinsons may reflect early subcortical & cortical cholinergic dysfunction rather than just peripheral auditory decline
academic.oup.com/braincomms/…
Using neuropsych. assessments, T1 imaging, & high angular resolution diffusion imaging data from 108 participants with #Parkinsons, researchers found that degeneration of the cortical cholinergic system is associated with cognitive decline in PD
movementdisorders.onlinelibr…
Longitudinal 3-month data from 40 #Parkinsons patients found that continuous subcutaneous foslevodopa/foscarbidopa infusion was associated with improvements in both motor complications & non-motor fluctuations
onlinelibrary.wiley.com/doi/…
Single-nucleus RNA sequencing, spatial transcriptomics & metabolomics in♂️A53T α-synuclein transgenic🐭finds "a disease-associated oligodendrocyte lineage marked by elevated Il33 & Kirrel3 that expands with pathology"; ⬆️in human #Parkinsons midbrain & CSF
nature.com/articles/s41467-0…
Researchers report that microglial NUS1 deficiency drives dopaminergic neurodegeneration through intercellular iron dysregulation in #Parkinsons models; Ferroptosis inhibitor liproxstatin-1 alleviated dopaminergic neuron loss & PD-like symptoms in mice
nature.com/articles/s41593-0…
Researchers applied "cell morphomics" (a machine-learning-based framework combining high-content imaging with quantitative feature extraction) to analyse mitochondrial & lysosomal morphology in iPS cell-derived neurons from #Parkinsons & control cases
nature.com/articles/s41531-0…
Analysis of 531 #Alzheimers cases that compared tau (PET) deposition patterns between α-synuclein–positive & α-synuclein–negative individuals found α-syn–positive cases had significantly⬆️tau deposition in basal ganglia, insula, & medial temporal lobe
alz-journals.onlinelibrary.w…
The write up of the 2025 German #Parkinsons Experts Meeting in Frankfurt/Main has been published. They explored structural challenges in the German clinical trial landscape & transforming the German Parkinson study group into a national infrastructure
link.springer.com/article/10…
"Involving people affected by #Parkinsons as equal partners in research has the potential to improve individual studies & to reshape the wider PD research agenda to be more inclusive, representative, & responsive to the priorities of those most affected"
journals.sagepub.com/doi/10.…
Researchers conducted a longitudinal study in polysomnography-confirmed iRBD patients with negative CSF α-synuclein at baseline. Among the 43 αSyn-negative patients, 9 (20.9%) converted to αSyn positivity over a mean follow-up of 2.8 ± 2.3 years
movementdisorders.onlinelibr…
Converters exhibited a higher burden of #Parkinsons biomarkers (eg hyposmia, abnormal DAT-SPECT, &⬆️REM sleep electromyographic activity, vs persistent αSyn negativity