let’s pay a chess game! @UCBerkeley phd • {Cancer, Immunology} ∩ {ML} | 🇲🇽

San Francisco, CA
Joined March 2020
Sergio Mares retweeted
We're launching a binding-affinity workflow today on Rowan! This workflow provides a unified interface for running different pose-scoring methods: GNINA, AEV-PLIG, Nesso-1, and SQM 2.20/TAQO-style single-point scoring. Testing different scoring methods is now trivial:
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Things are cooking
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great paper by @yumizsui "Adapting Boltz-2 with limited experimental activity data improves early enrichment in virtual screening", great follow up to Amini et al, very consistent with @RowanSci "tracking boltz2 benchmarks". great experiment set up
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from rowans blogs, there is still a big failure in OOD data, but at the expense of minimum training data there is a significant performance shift in the affinity head
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Sergio Mares retweeted
Please to announce that I have looked at some DNA and found a sequence I think is cool.
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Sergio Mares retweeted
I work in CRISPR discovery research. This is one of the most exaggerated nothing-burgers ever and would be laughed out of the room if a human scientist attempted to publish something like this. (cont.)
This is wild. Claude just found something humans missed. It spotted a hidden repeat pattern in raw bacteriophage DNA… …and uncovered a previously unknown enzyme system in bacteriophages with CRISPR-like repeats. 🤯 950 agents. 21 hours. 210M tokens.
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Sergio Mares retweeted
YC son or Horowitz Andreessen Academy daughter
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Today I realized he never held any public office positions
The Vivek fall off will be studied for centuries to come
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1/3 プレプリントを公開しました。Boltz-2のスクリーニング上位から選んだ数十から数百件の活性/非活性の測定結果だけでBoltz-2のaffinity headを微調整すると、スクリーニング性能が向上することを検証しました。 arxiv.org/abs/2609.24302
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as if it wasn't hard enough getting an olympic gold medal, now also joining OAI ugghhh see I cannot compete anymore
OpenAI researcher "Alisa Liu" had 57 interviews before joining OpenAI, and then She open-sourced her entire study notes job/learning process. - her LLM study notes - her math interview notes - a full honest write-up of the job process If you are preparing for research scientist / MTS roles, this is the highest-signal material available right now. You can use her notes or her topic list to study on your own. That’s rare. Don’t waste it.
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Sergio Mares retweeted
Wait until you guys find out about xgboost
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I hate when people describe themselves as foodie
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Sergio Mares retweeted
Individuals should be limited to submitting a single paper in their entire career. This will reduce the reviewing load at conferences and journals, p-values will not need to be corrected for testing performed in multiple papers, and publication charges will be manageable.
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Sergio Mares retweeted
well that was quick
The mountain lion makes a break for it as officials work to tranquilize it.
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Sergio Mares retweeted
BREAKING: U.S. military nearly intercepted a Chinese ship over an AI-generated intelligence report that falsely claimed it was carrying nuclear weapons components. — CNN
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Sergio Mares retweeted
i'm hiring a senior jev engineer at least 2 years of experience with jev is a requirement dm
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