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Sigel Lab

@sigel_lab

The Sigel lab focuses on the principles of metal ion-assisted folding and the structure of functional RNAs. | This group account is managed by students |

 Zurich, ZH - Switzerland
chem.uzh.ch/en/sigel.html
Joined April 2021
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Photo by Sigel Lab (@sigel_lab)Photo by Sigel Lab (@sigel_lab)Photo by Sigel Lab (@sigel_lab)Photo by Sigel Lab (@sigel_lab)Photo by Sigel Lab (@sigel_lab)Photo by Sigel Lab (@sigel_lab)Photo by Sigel Lab (@sigel_lab)Photo by Sigel Lab (@sigel_lab)Photo by Sigel Lab (@sigel_lab)Photo by Sigel Lab (@sigel_lab)
There's a joint spotlight collection on Bioinorganic Chemistry between Chemical Science and Dalton Transactions - and our paper on elucidating the structure of G4 quadruplexes (pubs.rsc.org/doi/D5SC01416F) has been selected! Check out the collection here: rsc.li/bioinorganic-spotligh…
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By the way, here's the beautiful cover picture!
Image from Sigel Lab (@sigel_lab)
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Congratulations to Matteo Lisibach for winning the Semesterpreis of the University of Zurich for his outstanding master thesis entitled "Toward multiple coordinates: Resolving the intrinsic heterogeneity of a group II intron folding and splicing process". Very well done Matteo!
A folded RNA molecule in the confocal volume of a microscope and a graph showing excitations in the Cy3 and Cy5 channel. Expanding the single-molecule FRET toolkit to tackle complex macromolecular dynamics.

ALT A folded RNA molecule in the confocal volume of a microscope and a graph showing excitations in the Cy3 and Cy5 channel. Expanding the single-molecule FRET toolkit to tackle complex macromolecular dynamics.

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Do you want to assign solution structures of G-quadruplexes using NMR? Maybe this new approach we just published works for you. Congrats to Zhenghui and Carla for this amazing work! doi.org/10.1039/D5SC01416F
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We are delighted to announce the Inorganic Chemistry Frontiers Outstanding Paper Awards 2014–2023！ Please join us in congratulating our winners, we hope you enjoy reading their outstanding articles as much as we did. rsc.org/journals-books-datab…
Image from InorgChemFront (@InorgChemFront)
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Roland and our PostDoc @LindlarNiko visited the EuroBIC17 in Münster last week. While Roland presented our work on the recently discovered theta ribozymes, Niko spoke about one of his projects from his Ph.D. in the @DaumannL Lab.
Image from Sigel Lab (@sigel_lab)
Image from Sigel Lab (@sigel_lab)
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A big shout out to @MuellerChem from Münster as well as Metzler-Nolte Lab from Bochum and Herris-Pawlis Lab from Aachen for putting together such a well-organized, well-caffeinated, and well-scienced conference!
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The Sigel group is coming out of the summer with a few news: Besim defended his Ph.D. thesis on illuminating the structure-function relationships in group II introns successfully! 🥳🥳Stay tuned for a publication about this!😉
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We also would like to welcome Lennart Lindner in our group! Lennart started his Ph.D. thesis this month in the smFRET group - we wish successful experiments, good coffee and many new experiences!🙏
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After 9 months it is time to say goodbye to our Japanese exchange student Minako - thank you for all the work you put in your NMR studies and, of course, the delicious cake!
Image from Sigel Lab (@sigel_lab)
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The chemistry booth at Science and Nature Festival powered by the Sigel lab - come join us at Campus Irchel today!
Image from Sigel Lab (@sigel_lab)
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We scientists have a responsibility to act against climate change. Part of that is advising and educating the public and part of it is keeping our own house in order. So, we applied and got the bronze LEAF - Laboratory Efficiency Assessment Framework - medal!
Image from Sigel Lab (@sigel_lab)
Image from Sigel Lab (@sigel_lab)
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And our application for silver is already in the making!
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The Sigel group is starting into summer with two new members: We welcome Benjamin and Matteo for their Master projects! Benjamin is doing a specialized Master in our NMR subgroup while Matteo is doing smFRET studies. We wish few failed experiments and lots of fun in the lab!
Image from Sigel Lab (@sigel_lab)
Image from Sigel Lab (@sigel_lab)
Image from Sigel Lab (@sigel_lab)
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We congratulate Federico Held for completing his master thesis with us. Federico introduced a heteroatom into RNA and used this to look at the BCL-2 RNA G-quadruplex. Thanks for the great time Fede!
Image from Sigel Lab (@sigel_lab)
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Last friday the Sigel group traveled to Bern. Why? To learn about RNA research in Switzerland at the Swiss RNA Workshop. Besim Fazliji, a Ph.D. candidate in our group, gave a talk about " Dissecting the exon binding mechanism in group II intron splicing" - and it was great!
Image from Sigel Lab (@sigel_lab)
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Check out our new preprint in collaboration with the @sigel_lab and find out more about Theta Ribozymes: Thousands of novel HDV-like, self-cleaving ribozymes that are often found next to viral tRNAs. biorxiv.org/content/10.1101/… #tRNA #biochemistry #ribozymes #bioinformatics
Discovery of Theta Ribozymes in Gut Phages–Implications for tRNA and Alternative Genetic Coding

Discovery of Theta Ribozymes in Gut Phages–Implications for tRNA and Alternative Genetic Coding

Ribozymes, relics of the “RNA world”, are essential across all domains of life. Nonetheless, the functions and genomic contexts of recently discovered small ribozymes, such as minimal hepatitis delta...

biorxiv.org
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Two weeks ago our Ph.D. students joined the CMSZH graduate school retreat - together with all other Ph.D. students from @UZH_Chemistry! It was a great time to enjoy Swiss mountains and learn about the fascinating research done at our own Department!
Image from Sigel Lab (@sigel_lab)
Image from Sigel Lab (@sigel_lab)
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And, among other things,@KKienbeck presented the new hot topics in our research. Pictures by Fan Liu of the Holland Lab.
Image from Sigel Lab (@sigel_lab)
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We congratulate Chantal Balmer on the successful completion of her Master's Thesis entitled "Influence of Substrate Structure on the Self-Cleavage of tRNA-Associated Ribozymes"! It was a blast having you!
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