Thomas Splettstößer🔬 (@splette) header
Thomas Splettstößer🔬 (@splette) profile picture

Computational biologist PhD turned scientific illustrator who mostly stopped using Twitter since it turned into X

Berlin, Germany
Joined December 2008
Photo by Thomas Splettstößer🔬 (@splette)Photo by Thomas Splettstößer🔬 (@splette)Photo by Thomas Splettstößer🔬 (@splette)Photo by Thomas Splettstößer🔬 (@splette)Photo by Thomas Splettstößer🔬 (@splette)Photo by Thomas Splettstößer🔬 (@splette)Photo by Thomas Splettstößer🔬 (@splette)Photo by Thomas Splettstößer🔬 (@splette)Photo by Thomas Splettstößer🔬 (@splette)Photo by Thomas Splettstößer🔬 (@splette)
My illustration is on the cover of this month's Lab on a Chip. A brain slice-on-chip – a microfluidic device that keeps living hippocampal tissue alive for weeks outside the body, with an electrode array recording the surviving circuits. As always hand-modeled & rendered in C4D
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Hello world! Been quiet here since 2021. Took a sabbatical, needed a break (mental health stuff), and honestly haven't been a fan of this platform since Elon took over. But I'm still around, still illustrating science, and might post again from time to time. Hi again.
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Scientists interested in dipping their toes into 3D modeling with the open-source tool Blender, check out this beginner tutorial:
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Frage zum #Beherbergungsverbot: Ich reise morgen geschäftlich von Berlin nach BaWü und werde dort nacheinander in 3 Hotels unterkommen. Ich habe einen negativen PCR-Covid-Test (150€) von gestern, also kein Problem für den ersten Check-In morgen. 1/2
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Dieser Test ist nur 1x erforderlich wenn man aus dem Hotspot in BaWü ankommt, korrekt? Oder muss ich mich alle 48 Stunden neu testen lassen, wenn ich das Hotel wechsele? Würde ich den ganzen Zeitraum im gleichen Hotel bleiben wären doch keine weiteren Tests nötig. #Verwirrung 2/2
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An abstract illustration of the map of neural connections in the human brain aka the #connectome (Averaged diffusion MRI data was prepared and exported with @FangChengYeh's DSI Studio and visualized with @insydium's X-particles and @maxon3d C4D) #brain #sciart #scistyle
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I used the travel-limited pandemic summer for another road trip with my friend Nico to Rügen, an island in the Baltic Sea. We went camping...
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...and visiting some ruins (again) originally intended by the Nazis as a recreation facility but never finished in the 1940s. Eerie and fascinating alike.
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Thomas Splettstößer🔬 retweeted
I had a joke about Motion Design, but the client wanted some last minute changes...
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Thomas Splettstößer🔬 retweeted
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Animation teaser of SARS-CoV-2, using the latest protein structures and models of glycosilated Spike, Membrane-protein dimer (green) and envelope protein (beige "starfish"). More to come soon. #sciart #scistyle #SARSCoV2 #science #COVID19
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Map of the SARS-CoV-2 genome. Some aspects of the genomes are peculiar (though none of them are suspicious with regards of human manipulation.) Thread /1
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Instead, they bring all necessary tools (proteins) to replicate their viral RNA-genome within the host cell them-self. Proteins of Open Reading Frame 1 (ORF1) and ORF2 are responsible for this viral replication process. Most other viruses do not have this "feature" /5
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The remaining proteins such as Spike, Membrane protein, Envelope Protein and Nucleocapsid (with the two copies of single-stranded RNA embedded) form the actual viral particle. /6
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Typical viruses have a genome between 5-10.000 nucleic bases. (Size has no relation to threat) Coronavirii such as SARS-CoV-2 with 30k bases have some of the largest known genomes among viruses. Their strategy is: not to rely on the human host cell for reproduction /4
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Coronavirus proteins encoded in ORF1 & ORF2 are called non-structural proteins (NSPs) because they are not required within the actual viral particle (to infect the next cell). Those structural proteins are for example Spike, Membrane protein, Envelope Protein and Nucleocapsid /5
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Updated illustration of SARS-CoV-2's trimeric spike glyco-protein, based on PDB structure (6VSB + added gycans). The Spike protein initiates binding and fusion with the human host cell and is a major target for antibody research. #covid19 #SARSCoV2 #sciart
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