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Excited to see our paper is out. Many thanks to @SjorsScheres @MichelGoed and team. Finishing the last challenging pieces of the puzzle provides us overarching perspectives on tauopathy codes which are made of misfolded tau proteins. nature.com/articles/s41586-0…
Co-pathology of #AD and #CTE in a #PART case gave us a chance to capture a mysterious binding site of PET ligand #flortaucipir in #CTE tau fibrils. The second binding type of ligand+amyloids, different from APN1607+#AD tau. Many thanks to @SjorsScheres and @MichelGoed as alwasys.
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BTW, I have moved to @Hangzhou_CHINA early this year and started my own group @ZJU_China. Will try to understand more about liand-amyloid interactions. New email address is [email protected]
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Years of efforts have been exerted in looking for #flortaucipir in #AD tau by cryo-EM. No convinced signal has been found so far, which is probably caused by low occupancy binding and high background in control.
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Something was wrong with the Figure 2 in the current biorxiv version. This is what we were expecting to upload🤣
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Fei (my PHD supervisor) and colleagues developed the ELI trifocal microscope, by setting up an electron (E) beam, a light (L) beam and an ion (I) beam at the same focal point to achieve accurate and efficient preparation of a target cryo-lamella.🤩👍biorxiv.org/content/10.1101/…
Looking forward to speaking with our collaborator @AbhayKot and colleague Sofia Lövestam. We will introduce how we use #cryoEM to improve our understanding in neurodegenerative diseases.
Tomorrow, I will be speaking with my collaborators @sy31802 and Sofia Lövestam from @SjorsScheres and @MichelGoed labs @MRC_LMB on their recent work using #cryoEM to look at neurodegenerative diseases 🧠🔬. Join us through the link below.
labroots.com/ms/webinar/tale…
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Yang Shi retweeted
Watch the recording of our #31AEC @AlzheimerEurope session "From bench to bedside: preclinical research in @IHIEurope neurodegeneration projects"
youtu.be/RJgkAzer8Yg
Yang Shi retweeted
This is a big deal… awesome work from the team!!
Introducing #AlphaCode: a system that can compete at average human level in competitive coding competitions like @codeforces. An exciting leap in AI problem-solving capabilities, combining many advances in machine learning!
Read more: dpmd.ai/Alpha-Code 1/
Yang Shi retweeted
OF MICE AND MEN. Many thanks to all, especially Yang, Diana and Wenjuan. As always, with @SjorsScheres science.org/doi/10.1126/scie….
It was a great moment to talk at @IMI2_NEURONET session @AlzheimerEurope's #31AEC. I hope it was simple enough for people to understand. Thanks @ChrisBintener and others!
It feels a bit like science fiction to enjoy this @IMI2_NEURONET session @AlzheimerEurope's #31AEC. Now, Yang Shi @sy31802 is speaking about how they identified different tauopathies using Cryo-EM technology. Research, recently published in @Nature nature.com/articles/s41586-0…
Pleasant to see our +APN-1607 PHF map & model highlighted by #PDB50structures. It is really a great encouragement for us to work harder on tau PET ligands with cryo-EM together with other techniques. Many thanks to @MichelGoed and @SjorsScheres for supports!
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Looking forward to presenting our work to mixed audiences, i.e., scientists, people living with dementia, health care staffs, policy makers etc. at #WeAreNeuronet. Many thanks to @ChrisBintener for the invitation and helps!
Recent research from the @IMI_JU funded @imprind project found that hierarchical classification of tauopathies complements clinical diagnosis of neurodegenerative diseases & also allows the identification of new entities
#WeAreNeuronet
bit.ly/NeuronetCampaign6
I initially found and solved the structures of TMEM106B type 1 filaments together with LNT tau filaments from an individual diagnosed as PSP. The buried terminal reminded us it would not be tau, then the story started…🧐
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Yang Shi retweeted
Time to announce I will start my own lab at Fudan University in Shanghai. Today is my last day at @MRC_LMB, beyond grateful to my mentors and colleagues helped me along the way, I will soon be recruiting postdocs so if you are interested in mitochondria, get in touch! #newPI
Yang Shi retweeted
Michel Goedert at #eurotau, I feel like half of my bibliography references from my PhD is talking right now
One of the most special day in my life. Many thanks for all of you to make this happen.
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Yang Shi retweeted
This week in Nature: Protein misfolds – Neurodegenerative diseases classified by shapes of tau filaments. Browse the issue here: go.nature.com/3mKuu9E