@tkam80

@mghmedres intern | prev @harvardMITmdphd @broadinstitute @macosko lab

 Cambridge
Joined July 2012
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  • Following296
  • Followers222
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Excellent work by @NadigAjay @Luke0connor !
Ajay Nadig@NadigAjay
Aug 31
How often is autism caused by de novo changes to the genome? What is the spectrum of penetrance across autism-associated genes? What can we expect from future autism gene discovery? I'm pleased to share a new preprint where we develop new statistical methods to answer these Qs.
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Tushar Kamath retweeted
AbdulAbdul@Abdul_Squared
May 12
Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$. With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s41593-0…

Optics-free spatial genomics for mapping mammalian brain aging by IRISeq

Nature Neuroscience - The authors developed an optics-free spatial genomics method to map mouse brain aging, revealing region-specific inflammation and showing that lymphocytes promote harmful...

nature.com
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Tushar Kamath retweeted
Amanda Urke@amanda_urke
Mar 2
2/8 Introducing Synapse-seq: our AAV-based tool for mapping brainwide presynaptic projections or postsynaptic distributions of molecularly-defined neurons, via protein-guided RNA barcoding & single-cell/spatial readouts: doi.org/10.64898/2026.02.26.…
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We are thrilled to have the following superstars join our fellowship program in July 2026.  Congratulations to Erik, Wes, Tushar, Brian, May and Shawna, and congratulations to the MGH GI Division for recruiting such talent.  Welcome to the family!
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A truly impressive synthesis of bio-psycho-social!
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Tarun Kamath@TVKamath
12 Nov 2024
The first piece of work from my PhD has now been uploaded to biorXiv! Short 🧵below:
bioRxiv Neuroscience@biorxiv_neursci
12 Nov 2024
Hunger modulates exploration through suppression of dopamine signaling in the tail of striatum biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Tushar Kamath retweeted
Luke O'Connor@Luke0connor
7 Nov 2024
Excited to share our preprint, describing a method for heritability partitioning with GWAS sumstats that significantly improves upon S-LDSC Led by the fantastic Hui Li, and co-supervised by @XihongLin #ASHG24 poster 4089F medrxiv.org/content/10.1101/…

Improved heritability partitioning and enrichment analyses using summary statistics with graphREML

Heritability enrichment analysis using data from Genome-Wide Association Studies (GWAS) is often used to understand the functional basis of genetic architecture. Stratified LD score regression...

medrxiv.org
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A particularly exciting way to look at transcriptional data using lessons learned from statistical genetics!
Ajay Nadig@NadigAjay
8 Jul 2024
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
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Tushar Kamath retweeted
Ajay Nadig@NadigAjay
8 Jul 2024
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
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Exciting stuff from @LaylaSiraj @julirsch and friends!
Layla Siraj, Ph.D.@LaylaSiraj
6 May 2024
Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays! biorxiv.org/content/10.1101/… See below for a 🧵. 1/n

Functional dissection of complex and molecular trait variants at single nucleotide resolution

Identifying the causal variants and mechanisms that drive complex traits and diseases remains a core problem in human genetics. The majority of these variants have individually weak effects and lie...

biorxiv.org
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What a fantastic presenter at SCGD!
Alex Cagan@ATJCagan
29 Mar 2024
Talk by @fluorocore on generalising single-cell analysis methods to spatial data #singlecellgenomicsday
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Thrilled to have matched at @MGHMedicine in the Stanbury PSTP! Thanks to all my mentors, family, and friends for the support and love. Thank you to all the patients who have taught me so much so far and the ones that I will learn from on my next journey! Doctorin’ soon! 🩺🫡
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Tushar Kamath retweeted
Evan Macosko@macosko
13 Dec 2023
We now know the locations of cell types in a full mammalian brain. Our work reveals the brainstem’s absolutely stunning cellular complexity. How and why does it arise? Visit braincelldata.org to plot genes, localize types, and get markers. nature.com/articles/s41586-0…
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Tushar Kamath retweeted
Evan Macosko@macosko
13 Dec 2023
Slide-tags unifies the single cell + spatial genomics worlds. It solves three key problems with existing spatial methods: 1) Cell segmentation (the biggest problem) 2) robustness and scalability (well-powered case-control studies now possible) 3) Multiomics (ATAC, RNA, etc)
Broad Institute@broadinstitute
13 Dec 2023
A new method called Slide-tags lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds upon Slide-seq, both developed by the labs of @insitubiology & @macosko. broad.io/slide-tags
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Excited to share the next chapter of primate genomics in @Nature, where we (@illumina, @IBE_Barcelona, and @bcmhouston) created a multiple sequence alignment of 239 primate species to better understand non-coding regulatory elements! nature.com/articles/s41586-0…
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Excited to announce I will be starting my lab in @BIDMCpath @BIDMC_CancerCtr at @BIDMC . Using chemical genomic approaches and thorough biochemistry we will focus on revealing new mechanisms of metabolism regulated cell death with a special focus on metal (copper) biology.
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Excited to share the final version of our manuscript detailing our work in understanding some of the earliest cellular changes in AD from brain biopsies of living individuals: cell.com/cell/fulltext/S0092…

Early Alzheimer’s disease pathology in human cortex involves transient cell states

Generating single-nucleus atlas from cortical biopsies of living individuals at early stage of Alzheimer’s disease, cell states of neurons, microglia, and oligodendrocytes associated with AD pathol...

cell.com
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A sentimental thanks to @macosko for all his support on what is likely the final contribution from my graduate thesis.
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I remember @macosko describing this project to me in my first week as a graduate student -- awestruck both then and now, I am immensely grateful to all those patients who contributed their brain tissue while still alive (!) to our efforts to understand Alzheimer's disease.
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