Tobia DeAngelis (@tobdea) header
Tobia DeAngelis (@tobdea) profile picture

pressure-tested and load-bearing

Global
Joined November 2012
Photo by Tobia DeAngelis (@tobdea)Photo by Tobia DeAngelis (@tobdea)Photo by Tobia DeAngelis (@tobdea)Photo by Tobia DeAngelis (@tobdea)Photo by Tobia DeAngelis (@tobdea)Photo by Tobia DeAngelis (@tobdea)Photo by Tobia DeAngelis (@tobdea)Photo by Tobia DeAngelis (@tobdea)Photo by Tobia DeAngelis (@tobdea)Photo by Tobia DeAngelis (@tobdea)
Tobia DeAngelis retweeted
Top Democrat strategist Van Jones, One of Obama’s former aides during his presidency Released this message to #Michigan on #AbdulElSayed #Midterms
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Tobia DeAngelis retweeted
How the All In podcast is gonna be talking next week
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Tobia DeAngelis retweeted
Replying to @johannesmboehm
@johannesmboehm and Chaney combine data on half a million ancient coins with a model of trade and money to reconstruct trade and consumption from AD 325 to 950. The estimates show economic activity shifting away from the Mediterranean from the 6th century. econometricsociety.org/publi…
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Tobia DeAngelis retweeted
europe must develop and produce advanced strategic capabilities for independent deterrence. we @generalcatalyst are co-leading @HypersonicaGmbH's €100M Series B together with @lightspeedvp read more: hypersonica.com/en/news/hype…
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Tobia DeAngelis retweeted
Woah, a potential treatment for food allergies ideated with help from a general purpose LLM and rapidly moved to experimental stage.
Today, in collaboration with Anthropic, we’re excited to share rapid initial progress towards an antibody treatment for food allergy, which affects over 200 million people worldwide, discovered with the help of Claude. At Divergence Labs, we believe that AI can unlock the next generation of antibody therapeutics with more effective mechanisms than before. Such mechanisms are urgently needed in food allergy, which involve overcoming one of the tightest affinity protein pairs in immunology, IgE and its receptor FcεRI, on mast cells. Treatment with Xolair—the only approved antibody for food allergy—sequesters circulating IgE, but mast cells remain sensitized for weeks to months due to the extraordinarily slow dissociation of IgE from FcεRI. We envision a treatment that actively pulls IgE off of FcεRI, without waiting for natural dissociation. Like picking a lock, this requires the right combination of geometry and force. Our research team, working with Claude, ideated on mechanisms to accomplish this disruption, and converged on an antibody format with two arms with different functions and epitopes. Within one month, we designed, synthesized, and experimentally confirmed the biophysical function of the two arms, which we are now assembling into full therapeutic formats.
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Tobia DeAngelis retweeted
"Analysts went with the agent's lean 86% of the time." "77% repeated the agent's argument in at least one answer, sometimes word for word. Only 15% credited the agent. About half called the final recommendation more their own than the agent's." Oh my god
New Anthropic research: How AI agents shape experts' judgment calls When experts delegate work to an agent, do they still make the key decisions? We tested this in a randomized trial with 50 professional data analysts.
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Tobia DeAngelis retweeted
Science is not some hobby that serves the self actualization of people in a publicly sponsored job placement program. It is the systematic search for truth.
Wow, over 1,000 mathematicians have now joined the Association for Human Mathematics (AHM), committing to: > NOT publish AI generated math papers > NOT work with frontier labs > 654 of them went even further to NOT even use AI in their research, at all
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Tobia DeAngelis retweeted
Tapping the sign:
Example #1,000,000 on how betting markets have no predictive value:
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Tobia DeAngelis retweeted
FT comments never miss. I don’t think I’ve read such a rational analysis of the situation we’re in for a long time.
I've been in France since 2002 and have never seen the streets so violent nor the politics so extreme. From the sacking of the supermarket on my street to the prospect of Présidente Le Pen, here's me @FT including thoughts from 2 French Nobel laureates as.ft.com/r/addcad57-0f9d-4e…
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Yeah we are debugging hard
3% of “critical” software security bugs, in all of recorded history, have been found in the last month. This is on pace to find another ~100,000 bugs this year alone, adding ~26% more vulnerabilities to the all time total Do you realize how fucking insane that is?
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Tobia DeAngelis retweeted
🚩 When Polymarket or Kalshi says there's a 70% chance something will happen, should we believe it? Excited to share our new paper, just published in PNAS, in which we examined more than ONE MILLION forecasts from Polymarket, Kalshi, Manifold, and Metaculus, spanning 12 domains and forecasting horizons ranging from hours to years. The main finding is striking: Prediction markets and collective forecasting platforms are remarkably well calibrated. When they assign events a 70% probability, those events really do happen about 70% of the time. And this pattern holds surprisingly well across different platforms, domains, and forecasting horizons. But there's an important twist. When we looked more closely, we discovered systematic biases in some of the domains where forecasting matters most (wars, elections). For decades, psychologists have documented how poorly humans often reason about probability and uncertainty. Our findings offer an encouraging counterpoint: When judgments and information are aggregated, we can achieve a surprisingly accurate understanding of an uncertain future. That doesn't mean we can predict what will happen next with certainty. But it does mean that we can be remarkably good at estimating how uncertain the future really is. This work was a great collaboration. The data for this project was meticulously collected for years by Justin Dickerson, the project was led by Hilla Shinitzky and Maayan Peer, with @mattansb leading the analyses. 📄 Read the paper: pnas.org/doi/10.1073/pnas.26… #Forecasting #Polymarket #Kalshi #DecisionScience #PNAS
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I predicted this exactly 10 years before it happened. L/S hiring feel free to reach out
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Tobia DeAngelis retweeted
no se si estoy viendo un debate presidencial o una batalla de aura
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Tobia DeAngelis retweeted
In July we open-sourced a dynamic graph of everything a child learns in primary school. 1,590 concepts, 3,221 dependencies. Now we’re turning every concept into interactive experiments kids can play and learn from. First one, age 7: heat and water. Everything that used to be a boring textbook can now be an engaging experience, potentially tailored to every child. Kids education just got a massive upgrade.
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Tobia DeAngelis retweeted
Billions of pounds lost on a single project because we can’t connect it to the grid for half a decade and have destroyed our capacity to generate reliable electricity.
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Tobia DeAngelis retweeted
TIL that global spending on alcohol is still larger than AI infrastructure spending this year ($1.7T vs $1.5T)
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Tobia DeAngelis retweeted
They’d rewrite the bible in Rust if you let them 😂
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Tobia DeAngelis retweeted
French Politicians answer to their economy imploding is money is fake. This will end great.
French Presidential Candidate Jean-Luc Mélenchon: They tell us, "We must reassure the markets." Reassure the markets? What are their names? Where do they live? Let me go and reassure them! What market? What are you talking about? There is no market. There are hedge funds, financial companies and insurance companies.
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Tobia DeAngelis retweeted
BREAKING: Further espionage insanity from China China owns the cars Norway’s soldiers rented for a military exercise. The cars proceeded to recorded the gate codes. The Home Guard used Hertz vehicles during a September drill in Oslo. Hertz’s ownership runs through Volvo to Zhejiang Geely. Soldiers found stored video of who got in, where they drove, and the codes they typed to open military gates. They kept using the cars. No replacements. Volvo still says Chinese ownership is not a risk. This is where reliance on Chinese tech leads you.
Norwegian soldiers discovered that Chinese-owned Volvo rental cars recorded and stored videos during a major military exercise in Oslo from September 14–18. The footage captured soldiers entering and leaving vehicles, their movements, locations and even security codes used to access restricted areas. Despite the discovery, the military continued using the cars due to a lack of alternatives. Source: DN
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Tobia DeAngelis retweeted
Two ant colonies have been fighting a war outside San Diego for decades. ~30M die a year. The front line is miles long.
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