RNA Biology, Computing, Heavy music, Videogames, and other horrible things. MSc: @Unipisa PhD: @MDC_Berlin Postdoc: @UCSF First supporter of the @CalvielloLab
Joined June 2021
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Happy too see this peer reviewed! A project stemming from work with @stephenfloor and @TheSilverLab, we focus on mRNAs who seem upregulated while translation is down or unchanged. If you're into RBPs, mRNA stability, the almighty GC content and much more, this one's for you!
Monitoring mRNA dynamics after DDX3X depletion indicates translation suppression followed by mRNA stabilization, with GC content in the CDS being a strong predictor of mRNA stabilization ➡️ embopress.org/doi/full/10.10… @translatomics @CalvielloLab @humantechnopole #RNAbiology
Lorenzo Calviello retweeted
A new paper published in Nature Astronomy says if LLM can easily replicate what counts as your scientific contribution, then the deeper problem is not the model, but the fact that the work was too routine, formulaic, or low-value to begin with.
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nature .com/articles/s41550-026-02837-2
Lorenzo Calviello retweeted
Exciting times - two more positions in my lab to work on poly(A) tail length regulation in mammalian (and not only!) cells. More details on the science and links to the positions (1 technician + 1 postdoc) below
🧬 What controls how long an #mRNA molecule survives inside a cell?
🔬 Our @ILegnini Group leads POLARIS, a new €1.35M FIS3 project exploring how poly(A) tails regulate mRNA stability and gene expression.
Read more 👉 humantechnopole.it/en/news/p…
Lorenzo Calviello retweeted
🧬 What controls how long an #mRNA molecule survives inside a cell?
🔬 Our @ILegnini Group leads POLARIS, a new €1.35M FIS3 project exploring how poly(A) tails regulate mRNA stability and gene expression.
Read more 👉 humantechnopole.it/en/news/p…
Lorenzo Calviello retweeted
Looking for bioinformatician for exciting projects across the Centre of Genomics at the Human Technople. We also work with the FANTOM6 Consortium and other international consortia/projects. Details in the call.
careers.humantechnopole.it/j…
Lorenzo Calviello retweeted
🧬 What if hidden proteins could become new immunotherapy targets?
💻 🔬 Our @translatomics Group secures a @AIRC_it My First Grant to uncover cancer-specific proteins in colorectal cancer with computational & organoid models
humantechnopole.it/en/news/f…
Lorenzo Calviello retweeted
🔬 Inside the cell’s #RNA control system: can cells sense and fine-tune their own mRNA levels?
🧬 Our @Fabio_Marcuccio has been awarded a #MSCA Postdoctoral Fellowship to explore how RNA stability is regulated, with long-term implications for therapies. humantechnopole.it/en/news/i…
Lorenzo Calviello retweeted
📣Following my PhD experience with @SENTINEL_ITN, I’m very happy to announce that I’ve been awarded a Marie Skłodowska-Curie Postdoctoral Fellowship for my project RNAhome🧬
Excited to continue my journey with @REA_research and @HorizonEU at @humantechnopole in beautiful Milan!🏔️
🔬 Inside the cell’s #RNA control system: can cells sense and fine-tune their own mRNA levels?
🧬 Our @Fabio_Marcuccio has been awarded a #MSCA Postdoctoral Fellowship to explore how RNA stability is regulated, with long-term implications for therapies. humantechnopole.it/en/news/i…
Lorenzo Calviello retweeted
Online Now: Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome dlvr.it/TN0GcP
Lorenzo Calviello retweeted
The EU initiative has crossed 1.25 million signatures! I think 250k is the current record for invalid signatures thrown out on other initiatives, so we MIGHT be safe, but I could see us breaking that record also. The more margin we get, the better!
eci.ec.europa.eu/045/public/…
Lorenzo Calviello retweeted
Neural Cellular Automata (NCA) are a new approach combining AI with mechanistic modelling. We designed a novel NCA architecture to handle the stochasticity of biological tissues. These can be trained on spatial 'omics data to *learn the rules* of normal and cancer growth.
📄 In this work, we try to bridge two parallel research areas: the well-established literature on agent-based modeling in biological systems and recent advances in learning update rules in CA from data with autodifferentiation.
arxiv.org/abs/2506.20486
Lorenzo Calviello retweeted
📄 In this work, we try to bridge two parallel research areas: the well-established literature on agent-based modeling in biological systems and recent advances in learning update rules in CA from data with autodifferentiation.
arxiv.org/abs/2506.20486
Come have fun with us on many multidisciplinary projects!
🚨 Fully funded #PhD opportunities at Human Technopole in Milan!
🔬 Apply by 9 June to join top research groups in Comp Bio, Struct Bio, Genomics, Neurogenomics, Mol Cell Bio
🌍 Open to grads worldwide via @semm_it 👉 humantechnopole.it/en/news/1…
Lorenzo Calviello retweeted
💡 Thinking about a PhD?
✨ Join us on 15 April for the PhD Open Day at Human Technopole! Explore cutting-edge research, meet our Group Leaders, and discover training opportunities in an international, dynamic environment.
Register now 👉 humantechnopole.it/en/traini…
Lorenzo Calviello retweeted
Great collaboration as detailed in the thread and another first author paper for @francescocist9 from my group! 😊
🚀 Thrilled to announce our latest #preprint on intraplaque haemorrhage (IPH) quantification and molecular 🧬characterisation of carotid plaques using deep learning. A thread 🧵👇🏽
Lorenzo Calviello retweeted
In Milan @humantechnopole we opened core-funded computational Group Leader positions in one or more of bioimage analysis, spatial ‘omics, AI for genomes and proteins, computational simulations of cells and tissues. Come to lead your research programme! careers.humantechnopole.it/o…
Lorenzo Calviello retweeted
Hey #teamtomo!📢@humantechnopole is recruiting new group leaders in Computational Structural Biology!📢 “Mapping biomolecular complexes across scales using cryo-EM🔬and cryo-ET❄️data, using LLMs🤖for in silico inference of protein function and mechanisms”: careers.humantechnopole.it/o…