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Youngdo Koo, PhD

@ydkoophd

Assistant Professor, Division of Endocrinology, Diabetes & Metabolism at University of California, Los Angeles [email protected] [email protected]

 Valencia, CA, USA
Joined November 2019
  • Tweets223
  • Following316
  • Followers136
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Photo by Youngdo Koo, PhD (@ydkoophd)Photo by Youngdo Koo, PhD (@ydkoophd)Photo by Youngdo Koo, PhD (@ydkoophd)
Youngdo Koo, PhD retweeted
E. Dale Abel (@IntMedAbel) profile picture
E. Dale Abel@IntMedAbelApr 14
Sharing our new publication by @ydkoophd in @jclinicalinvest revealing a non-autophagy role for ULK1 in the pathophysiology fatty liver disease and its progression to MASH and fibrosis jci.org/articles/view/191101
Image from E. Dale Abel (@IntMedAbel)
Image from E. Dale Abel (@IntMedAbel)
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Offering a potential drug target to prevent fatty liver progression and fibrosis: doi.org/10.1172/JCI191101 Young Do Koo @ydkoophd E. Dale Abel @IntmedAbel & team @dgsomucla report ULK1 suppresses hepatic steatohepatitis by regulating lipid metabolism and antioxidant pathways via NCOA3 phosphorylation. The figure image shows autophagosomes in HFD-fed mice with hepatic deficiency of ULK1 #MASH #OxidativeStress
Image from Journal of Clinical Investigation (@jclinicalinvest)
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Replying to @jclinicalinvest @ydkoophd @IntMedAbel @dgsomucla
Behind the Scenes with Young Do Koo @ydkoophd and E. Dale Abel @IntmedAbel discussing the significance and impact of their study.
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Replying to @jclinicalinvest @ydkoophd @IntMedAbel @dgsomucla
The ULK1-NCOA3 axis restrains de novo lipogenesis and prevents diet-induced steatohepatitis and fibrosis in mice: doi.org/10.1172/JCI191101
Image from Journal of Clinical Investigation (@jclinicalinvest)
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New! Online now: Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice dlvr.it/TMB0yf
Image from Cell Metabolism (@Cell_Metabolism)
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FGF21 reverses MASH through coordinated actions on the CNS and liver dlvr.it/TLjSnX
Image from Cell Metabolism (@Cell_Metabolism)
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New! Online now: FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression dlvr.it/TLNfFX
Image from Cell Metabolism (@Cell_Metabolism)
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Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy dlvr.it/TL9ZF0
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Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism dlvr.it/TL8Pky
Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism

Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism

Wang et al. reveal that DLAT, a pyruvate metabolism enzyme, modulates leucine metabolism by directly acetylating the leucine catabolism enzyme AUH at K109, leading to leucine accumulation and...

cell.com
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Youngdo Koo, PhD retweeted
Matthew Potthoff (@potthofflab) profile picture
Matthew Potthoff@potthofflab19 May 2025
FGF21 analogs reduce liver steatosis and fibrosis in patients with MAFLD/MASH. Our new paper provides insight into the mechanisms for these effects: cell.com/cell-metabolism/ful… @HammDiabetesCtr @OUHealth
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New! Online now: Acetylated cellulose suppresses body mass gain through gut commensals consuming host-accessible carbohydrates dlvr.it/TKpZlQ
Image from Cell Metabolism (@Cell_Metabolism)
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New! Online now: Foxp3 confers long-term efficacy of chimeric antigen receptor-T cells via metabolic reprogramming dlvr.it/TKZGgL
Image from Cell Metabolism (@Cell_Metabolism)
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New! Online now: Fasting-induced ketogenesis sensitizes bacteria to antibiotic treatment dlvr.it/TKVFsK
Image from Cell Metabolism (@Cell_Metabolism)
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Starvation induces metabolic hepatocyte reprogramming go.nature.com/42GRRWx
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Signalling from adipose tissue to the brain is not just about leptin go.nature.com/3XXwIGb
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New! Online now: Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy dlvr.it/TK5hqS
Image from Cell Metabolism (@Cell_Metabolism)
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New! Online now: O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles dlvr.it/TK4lJ4
Image from Cell Metabolism (@Cell_Metabolism)
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Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue - ScienceDirect sciencedirect.com/science/ar…
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Hepatic stellate cells regulate liver fatty acid utilization via plasmalemma vesicle-associated protein dlvr.it/TJzF6g
Image from Cell Metabolism (@Cell_Metabolism)
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Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming dlvr.it/TJyJMT
Image from Cell Metabolism (@Cell_Metabolism)
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