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Yeow Jiang

@yeowjiang
Joined August 2012
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Photo by Yeow Jiang (@yeowjiang)Photo by Yeow Jiang (@yeowjiang)Photo by Yeow Jiang (@yeowjiang)Photo by Yeow Jiang (@yeowjiang)
@hervecelia from the Buchanan Lab also reported ~1.5 mths ago amazing cryo-EM structures of not only TolQRA but also the ExbBD-TonB complex! Awesome to see our independent studies converging on these motor-stator-effector structures! biorxiv.org/content/10.1101/…
Cryo-EM structures of the E. coli Ton and Tol motor complexes

Cryo-EM structures of the E. coli Ton and Tol motor complexes

The Ton and Tol motor proteins use the proton gradient at the inner membrane of Gram-negative bacteria as an energy source. The generated force is transmitted through the periplasmic space to protein...

biorxiv.org
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In case you missed it, the brilliant @WeeBoon5 also recently established the primary role of the Tol-Pal complex in outer membrane lipid homeostasis, using an engineered TonB-TolA chimera! #SGBUG @SCELSE_SG @ChemNUS biorxiv.org/content/10.1101/…
Primary role of the Tol-Pal complex in bacterial outer membrane lipid homeostasis

Primary role of the Tol-Pal complex in bacterial outer membrane lipid homeostasis

Gram-negative bacteria are defined by an outer membrane (OM) that contributes to envelope integrity and barrier function. Building this bilayer require proper assembly of lipopolysaccharides,...

biorxiv.org
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Delighted to share a sequel to our OmpC-MlaA biochemical adventures and my graduate research story! A big thanks to @Figlegend for being an extremely supportive and encouraging supervisor, and Prof. Min Luo for the exciting collaboration! nature.com/articles/s41467-0…
Molecular mechanism of phospholipid transport at the bacterial outer membrane interface

Molecular mechanism of phospholipid transport at the bacterial outer membrane interface

Nature Communications - Maintenance of lipid asymmetry in the bacterial outer membrane (OM) is mediated by the OmpC-Mla system, but mechanistic details remain to be elucidated. Here, the authors...

nature.com
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Finally, in our updated preprint on 24 February 2023, we characterized a disulfide-trapped OmpC-MlaA-MlaC complex in nanodiscs that supports our findings above, and intriguingly reveals membrane thinning to be a plausible strategy for directing lipids for transport.
Image from Yeow Jiang (@yeowjiang)
Image from Yeow Jiang (@yeowjiang)
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It was thrilling to be working on this project surrounded by supportive lab colleagues, with their insightful discussion and constant encouragement. Grateful to all (esp. collaborators, examiners, and reviewers) that have contributed to this wholesome journey. 😊
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Days in circuit breaker 1/7 A picture a day for a week, no people, no explanations. Nominated by @wenyilow I invite labmate @WeeBoon5
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Congrats! Awesome stuff! 😄
Georgia Isom (@GL_Isom) profile pictureGeorgia Isom@GL_Isom30 Apr 2020
Excited that this work is now officially published in Cell! A tunnel that spans the bacterial cell envelope and transports lipids between the two membranes....#cryoEM #lipidtransport #bacteria #teamwork authors.elsevier.com/c/1a~ee…
Image from Georgia Isom (@GL_Isom)
What a great piece. I could not agree more. In Defense of an Academic Career in Microbiology msphere.asm.org/content/3/3/…
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Curious what the biofilm on your tongue looks like? Here you have it. Quite beautiful. From Jessica Mark Welch #ECCMID2019
Image from Kendra Rumbaugh (@KendraRumbaugh)
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Newest preprint from the lab on novel effects of ECA intermediates on the outer membrane! Pls give us feedback!
bioRxiv (@biorxivpreprint) profile picturebioRxiv@biorxivpreprint29 Nov 2018
Biosynthetic intermediates of the enterobacterial common antigen overcome outer membrane lipid dyshomeostasis in Escherichia coli biorxiv.org/cgi/content/shor… #bioRxiv
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Biosynthetic intermediates of the enterobacterial common antigen overcome outer membrane lipid dyshomeostasis in Escherichia coli biorxiv.org/cgi/content/shor… #bioRxiv
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Extremely honored to be awarded the 2019 ASBMB Walter Shaw Young Investigator Award! Oh wow.. totally unbelievable! nitter.cf/ASBMB/status/101246577…
ASBMB (@ASBMB) profile pictureASBMB@ASBMB28 Jun 2018
Congratulations to our annual award winners! The recipients will give talks about their work at the society's 2019 annual meeting. asbmb.org/News.aspx?id=77169 #ASBMB2019
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Seriously, what gas did you guys use for this? 😂😂 @clar_nwt @phoenixflames93 @siewyannnn @chewzs0o
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Yeow Jiang retweeted
Words (@wordstionary) profile picture
Words
@wordstionary27 Aug 2014
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Oh the messenger...
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I don't want to accept the fact that school is starting tmr :(
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