The Zhou Lab (@zhou_lab) header
The Zhou Lab (@zhou_lab) profile picture

The Zhou Lab

@zhou_lab

We are the Zhou Lab @UCLA. We use #cryoEM and #cryoET to study viruses, viral proteins, protein assemblies, and membrane proteins. Student-curated account.

 University of California, Los
Joined May 2019
  • Tweets88
  • Following139
  • Followers1.6K
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Photo by The Zhou Lab (@zhou_lab)Photo by The Zhou Lab (@zhou_lab)Photo by The Zhou Lab (@zhou_lab)Photo by The Zhou Lab (@zhou_lab)Photo by The Zhou Lab (@zhou_lab)Photo by The Zhou Lab (@zhou_lab)Photo by The Zhou Lab (@zhou_lab)Photo by The Zhou Lab (@zhou_lab)Photo by The Zhou Lab (@zhou_lab)
We're so proud to be featured on the cover of @nature! Brilliant work from Dr. Peng Ge and team, uncovering intricacies of the fascinating P. aeruginosa bacteriocin at high resolution using #cryoEM.
Nature Portfolio (@NaturePortfolio) profile pictureNature Portfolio
@NaturePortfolio29 Apr 2020
This week on the Nature cover: Molecular syringe. High-resolution structures shed light on the workings of an antibacterial nanomachine. Browse the issue here: go.nature.com/2xg3N6W
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Our study on the atomic structure of the T. brucei microtubule, has been published in Science and featured in UCLA News! This work was led by Dr. Xia @xianxia13 in collaboration with colleagues from Dr. Kent Hill's and Dr. James Wohlschlegel's labs. newsroom.ucla.edu/stories/at…
Image from The Zhou Lab (@zhou_lab)
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Here is the link to the article. science.org/doi/10.1126/scie… We are also excited to see the accompanying paper on the doublet structure of trypanosomatid parasites from the labs of Rui Zhang and Alan Brown. science.org/doi/10.1126/scie…
Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms

Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms

The flagellum of Trypanosoma brucei drives the parasite’s characteristic screw-like motion and is essential for its replication, transmission, and pathogenesis. However, the molecular details of this...

science.org
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The Zhou Lab retweeted
Hui Wang (@HuiWang007) profile picture
Hui Wang@HuiWang00713 Dec 2024
Excited to share our latest work: Using cryoET, we unraveled the in situ structure of a methanogen surface layer and its cell envelope. Now published in Science Advances! #teamtomo science.org/doi/10.1126/scia…
Composition and in situ structure of the Methanospirillum hungatei cell envelope and surface layer

Composition and in situ structure of the Methanospirillum hungatei cell envelope and surface layer

Cryo–electron tomography of the cylindrical archaeal cell resolves the surface layer structure and subunit interactions.

science.org
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Please check out our just published Nature paper "Native DGC structure rationalizes muscular dystrophy-causing mutations", the excellent teamwork from @ShihengLiu @ tiantiansu and @xianxia13
Shiheng Liu (@ShihengLiu) profile pictureShiheng Liu@ShihengLiu11 Dec 2024
Thrilled to share our latest work: native cryo-EM structure of the Dystrophin-Glycoprotein Complex (DGC) is now published in Nature! nature.com/articles/s41586-0… This discovery sheds new light on the molecular basis of muscular dystrophies and pave the way to novel therapies.
Native DGC structure rationalizes muscular dystrophy-causing mutations

Native DGC structure rationalizes muscular dystrophy-causing mutations

Nature - The detailed structure of the native dystrophin–glycoprotein complex provides mechanistic insights into mutations underlying muscular dystrophy.

nature.com
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Excited to share our new work! We shed light on the sociology of virus-induced condensates supporting reovirus assembly and replication. Visualized using #CryoET #CryoEM and #FIBmilling nature.com/articles/s41467-0… Great collab w/ @xianxia13 @zhou_lab Xiaoyu Liu @gonenlab
Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replic...

Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replic...

Nature Communications - Virus-induced cellular condensates are poorly understood. Using cryoET and cryoEM, the authors visualized the 3D “molecular sociology” of host-virus interactions...

nature.com
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Proud to see the spIsoNet is online now! Hope you enjoy using it!
Nature Methods (@naturemethods) profile pictureNature Methods@naturemethods18 Nov 2024
Introducing spIsoNet, a software tool that addresses the challenges of map anisotropy and particle misalignment in cryo-EM caused by the preferred orientation problem. @zhou_lab @yuntaoinnit @hongcheng_fan nature.com/articles/s41592-0…
Image from Nature Methods (@naturemethods)
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The Zhou Lab retweeted
Chi-Min Ho (@mimi1inh) profile picture
Chi-Min Ho@mimi1inh18 Jun 2024
We have a fully-funded postdoc position in the @cmholab in #NYC to study how #membraneproteins drive host-pathogen interactions in #malaria parasites using #CryoEM and #CryoET!🦠❄️🔬Email [email protected] with your CV to apply! tinyurl.com/5n96rkfm #teamtomo
Image from Chi-Min Ho (@mimi1inh)
Image from Chi-Min Ho (@mimi1inh)
Image from Chi-Min Ho (@mimi1inh)
Image from Chi-Min Ho (@mimi1inh)
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The Zhou Lab retweeted
Hui Wang (@HuiWang007) profile picture
Hui Wang@HuiWang00715 May 2024
TomoNet is now published in Biological Imaging! It is a 100% GUI-based cryoET integration pipeline package. Specifically, we offer two major options for high-throughput particle picking to achieve high-resolution STA. Please check the website for details. #cryoET #teamtomo
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spIsoNet is available on Biorxiv and GitHub now!
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Beautiful work from Xian @xianxia13 and our amazing collaborators!
Mike Martynowycz (@ScienceMick) profile pictureMike Martynowycz@ScienceMick12 Apr 2024
Excited to share our latest work in @CellCellPress on how bluetongue virus packages its RNA & assembles its capsid inside host cells! Using #cryoET & #cryoEM, we've visualized this process with 11 structures. Great collab w @gonenlab @zhou_lab 🦠🔬 cell.com/cell/abstract/S0092…
Image from Mike Martynowycz (@ScienceMick)
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The Zhou Lab retweeted
Hui Wang (@HuiWang007) profile picture
Hui Wang@HuiWang00720 Feb 2024
Our preprint of TomoNet is online now!
bioRxiv Cell Biology (@biorxiv_cellbio) profile picturebioRxiv Cell Biology@biorxiv_cellbio19 Feb 2024
TomoNet: A streamlined cryoET software pipeline with automatic particle picking on flexible lattices biorxiv.org/cgi/content/shor… #biorxiv_cellbio
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Check out our latest preprint work on SARS-CoV-2 Nsp15: biorxiv.org/content/10.1101/… We present cryo-EM structures of SARS-CoV-2 Nsp15 bound to its physiological substrate polyU containing RNA, illuminating the basis for immune evasion tactics by coronaviruses!
Image from Fumiaki Ito (@FumiakiIto110)
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The Zhou Lab retweeted
Hui Wang (@HuiWang007) profile picture
Hui Wang@HuiWang00724 Oct 2023
Our paper is out! We resolved the sheath structure from M. Hungatei cells using cryoET. ⁦⁦Thanks to all the coauthors @zhou_lab⁩ and Gunsalus lab.⁦#TeamTomo nature.com/articles/s41467-0…
Hierarchical organization and assembly of the archaeal cell sheath from an amyloid-like protein

Hierarchical organization and assembly of the archaeal cell sheath from an amyloid-like protein

Nature Communications - Cellular cryoET reveals how an amyloid-like protein of the prototypical archaeon, Methanospirillum hungatei, oligomerizes into a ring containing a giant 2700-strand β...

nature.com
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The Zhou Lab retweeted
Chi-Min Ho (@mimi1inh) profile picture
Chi-Min Ho@mimi1inh8 Sep 2023
We're also recruiting postdocs! DM or email if you'd like to join us in using integrated structural biology approaches combining #CryoEM and #insitu #CryoET to study #membraneproteins and molecular machines in #malaria parasites! Check it out👇👉tinyurl.com/5n96rkfm #teamtomo
Image from Chi-Min Ho (@mimi1inh)
Image from Chi-Min Ho (@mimi1inh)
Image from Chi-Min Ho (@mimi1inh)
Image from Chi-Min Ho (@mimi1inh)
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Congrats!
Fumiaki Ito (@FumiakiIto110) profile pictureFumiaki Ito@FumiakiIto11028 Aug 2023
Check out our latest paper on HIV Vif-APOBEC3H complex structure by cryo-EM: nature.com/articles/s41467-0… This has been a collaborative project between @zhou_lab and Xiaojiang Chen lab at USC.
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Check out the recent cryoET work with our beloved colleagues in Hill lab on the flagella structure of T. Brucei. nature.com/articles/s41467-0…
FAP106 is an interaction hub for assembling microtubule inner proteins at the cilium inner junction

FAP106 is an interaction hub for assembling microtubule inner proteins at the cilium inner junction

Nature Communications - Microtubule inner proteins (MIPs) contribute to species-specific motility characteristics but are largely unstudied. Here, the authors combine functional, structural and...

nature.com
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Check out our cryoEM result of mRNA editosome in Trypanosoma brucei! Awesome collaboration with Aphasizhev lab from Boston U. Many congrats to Bruce @ShihengLiu⁩ and other coauthors for another wonderful piece of work! science.org/doi/10.1126/scie…
Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing

Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing

Structural analysis of the RNA editosome reveals mechanisms of guide RNA recognition and messenger RNA engagement.

science.org
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Congrats to Jason, Jane and Yuntao @yuntaoinnit
Structure (@Structure_CP) profile pictureStructure@Structure_CP13 Jan 2023
The group of Hong Zhou @MicrobioUcla & their collaborators determined the cryo-EM structure of filamentous 3-methylcrotonyl-CoA carboxylase from Leishmania tarentolae and discuss its mechanism @zhou_lab doi.org/10.1016/j.str.2022.1…
Image from Structure (@Structure_CP)
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Long-lasting enigma in HIV study: how HIV antagonizes the host antiviral systems and evades the immunity? We are addressing the question by cryo-EM structure of Vif-APOBEC3G complex, which emerged as an unusual ribonucleoprotein complex: science.org/doi/10.1126/scia…
Image from Fumiaki Ito (@FumiakiIto110)
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Atomic model of vesicular stomatitis virus and mechanism of assembly @zhou_lab #virology #CryoEM #structures go.nature.com/3Tq5EKk
Image from Nature Communications (@NatureComms)
Image from Nature Communications (@NatureComms)
Image from Nature Communications (@NatureComms)
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