Happy to present our structure of the Wnt/Fzd/LRP6 ternary complex from the Garcia lab at Stanford
biorxiv.org/content/10.1101/…
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How to train your cytokine with @rsaxton_ and Chris Garcia rdcu.be/cV10R
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Happy to share our review on #cytokine pharmacology and therapeutics, out now in @NatRevDrugDisc! Written with @CalebGlassman and Chris Garcia, we discuss the 'tunable parameters' of cytokine signaling, and how they can be exploited therapeutically
nature.com/articles/s41573-0…
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Beyond excited to present some of our most recent work on the IL-17 family of cytokines. @Nature Accelerated Article Preview available now! nature.com/articles/s41586-0… This was an amazing collaboration started by the one and only @steven_c_wilson! (1/9)
Congrats @steven_c_wilson and @CaveneyNA! This is another quantum leap in the cytokine structural biology field.
nature.com/articles/s41586-0…
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For more than 25 years, researchers around the world have been trying to find the structure of Janus kinases, or JAKs, a class of proteins that have been tied to many cancers and autoimmune diseases. stan.md/3MG3tQT
#Immunology #Cancer #ScienceTwitter
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HHMI News: After more than two decades of effort, scientists have solved the full-length structure of a Janus Kinase, a crucial signaling molecule, opening the door to new and better drugs for some cancers.
bit.ly/3t2QRvv
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Our structure of an active Janus Kinase-Cytokine Receptor dimer is out in @ScienceMagazine. We found a dimerization interface between apposing pseudokinase domains that is stabilized by oncogenic Val-Phe mutation resulting in ligand-independent activation science.org/doi/10.1126/scie…
Excited to present our work tackling a classic question: How do cytokine receptors and oncogenic mutations activate Janus Kinases? @ScienceMagazine
Led by my buddy @CalebGlassman (lnkd.in/gMGHQYQm) from the Garcia Lab, now…lnkd.in/gXHq6zVQ lnkd.in/gQuPjHtC
The links above might not be posted appropriately.
science.org/doi/10.1126/scie…
hhmi.org/news/after-more-20-…
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New preprint up now with @CaveneyNA. We find that IL-27 assembles a receptor complex similar to IL-6 but distinct from other heterodimeric cytokines such as IL-12 and IL-23. Check out NAC's thread for the 📖. biorxiv.org/cgi/content/shor…
Excited to share today the first of my postdoctoral work - the structure of the IL-27 signaling complex: doi.org/10.1101/2022.03.08.4…
This was a great team effort working w/ the one and only cytokine cowboy @CalebGlassman, Kevin Jude, @1987NT, and Chris Garcia. Tweetorial to follow:
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Excited to share today the first of my postdoctoral work - the structure of the IL-27 signaling complex: doi.org/10.1101/2022.03.08.4…
This was a great team effort working w/ the one and only cytokine cowboy @CalebGlassman, Kevin Jude, @1987NT, and Chris Garcia. Tweetorial to follow:
Look at this beautiful structure by the two young stars from the Garcia Lab, Nathanael Caveney (@CaveneyNA) and @CalebGlassman! Nicely resolved all three interfaces.
lnkd.in/g2FtmcVW lnkd.in/gQNdzVmp
Happy to share more structural implications for viral GPCRs.
They are enigmatic but appear to represent differences between robust Gq and less efficient Gi signaling of US28. Through evolution, US27 lost the ability to bind a chem…lnkd.in/dPuKaSgW lnkd.in/daThRyVK
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Our paper on calibrating IL-2 signaling is out today in @eLife! We used structure-based engineering to identify a regulatory T cell biased agonist of IL-2 receptor that exploits cell-intrinsic differences in cytokine sensitivity.
elifesciences.org/articles/6…
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Our paper on IL-12 and IL-23 is out today in @CellCellPress! Using structures of the IL-12 and IL-23 receptor complexes, we engineered versions of IL-12 that support T cell anti-tumor immunity without NK cell toxicity
authors.elsevier.com/a/1cc0a…
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Very happy to share our work on IL-22 out today in @ImmunityCP! We used structure-based engineering to develop IL-22R agonists that elicit both biased STAT activation AND tissue selectivity, promoting tissue protection without inducing inflammation.
authors.elsevier.com/c/1cu~c…
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Very excited to share our work on IL-10 out today in @ScienceMagazine! We solved the cryo-EM structure of the IL-10 receptor complex and used it to design myeloid-selective IL-10 variants that uncouple its pro- and anti-inflammatory effects science.sciencemag.org/conte…
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Online now: Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1 dlvr.it/S2xRgH
* Non-COVID-19 research
I'm excited to share our work on a virally-encoded GPCR online, revealing the uniquely evolved 7TM configuration in comparison with prototypical endogenous GPCRs.
I thank my advisor Chris, and everybody who…lnkd.in/g9eCkJd lnkd.in/gCWzYQa
