Assoc. Prof. at National Taiwan Univ. | Researcher in genetic epidemiology and statistical genetics | Previously at @MGH_RI and @broadinstitute
Taipei, Taiwan
Joined April 2011
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Anne Feng retweeted
Thrilled to announce our latest study published in @CellGenomics !
cell.com/cell-genomics/fullt…
Big shoutout to our amazing collaborators @ChiayenChen @getian107 @hailianghuang @AnnejaneF and many others!
#GWAS #TaiwanBiobank🧬
Great collaboration, delighted to be part of it!
Hi everyone,
Our paper about boosting the power of GWAS using polygenic scores (PGS) is just out in @NatureGenet. Please check it out here: nature.com/articles/s41588-0…
Anne Feng retweeted
Great paper from the Epi25 collaborative on the rare variant associations of different types of epilepsy based on WES analysis of ~54k individuals. This paper is packed with insightful findings. I'll highlight a few 🧵
medrxiv.org/content/10.1101/…
Anne Feng retweeted
New preprint! We studied how rare protein-coding variants impact cognitive function & linked diseases in @uk_biobank. We identified 8 large-effect cog fx genes, dosage-sensitivity for KDM5B, additivity of rare variant and polygenic risk & more (1/12) medrxiv.org/content/10.1101/…
Anne Feng retweeted
Do medically-actionable genes have effects on psychiatric disorders? Targeted deep sequencing in 15K individuals from @eMERGENetwork_ Led by @AnnejaneF #pleiotropy #PheWAS @TheACMG @GeneticCouns pubmed.ncbi.nlm.nih.gov/3559…
Anne Feng retweeted
I predict 2022 as the Year of the National Biobanks. After many years of investment, they are now generating data at a population-scale. MVP. FinnGen.All of Us. Estonia. UKGH. UKBB. Retweet w/ other examples @AllofUsCEO @FinnGen_FI @dvh13 @zakkohane @atulbutte @dalygene – at Wellesley, MA
An interesting overview of the Taiwan Biobank and its design/phenotypes. Genetic data for 110k people (strangely, genotyped on two arrays with little overlap, and not using their own WGS for imputation). >9k pairs of first degree relatives.
medrxiv.org/content/10.1101/…
Anne Feng retweeted
So depressing rereading this thread of the first embryo selection by broad genomic profiling from healthy donors in the US
Bloomberg reports the claim of the first child born following polygenic screening as an embryo, via a company called Genomic Prediction.
Basically a test that rank orders embryos by health using genome wide profile 🧵
bloomberg.com/news/articles/…
Anne Feng retweeted
Today we are thrilled to announce the #COVID19 HGI manuscript is published @Nature nature.com/articles/s41586-0…
In this study, we report that the human genome significantly contributes to an individual’s response to SARS-CoV-2 infection.
1/
Anne Feng retweeted
Fantastic to have this paper out! Julia Goodrich and @miriam_udler did a seriously heroic amount of work to explore a critical question: if you carry a rare variant previously reported as causing a "monogenic" disease, how likely are you to actually have the disease?
Goodrich et al. use exome sequencing data from 77,184 individuals to generate penetrance estimates and assess the utility of polygenic variation in risk prediction of monogenic variants.
@CGM_MGH @broadinstitute @miriam_udler @dgmacarthur
nature.com/articles/s41467-0…
Anne Feng retweeted
I’m excited to share DeepNull, led by @FHormozdiari from the Genomics team in @GoogleHealth, which improves statistical power of GWAS by better modeling non-linear interactions between covariates, which improves detection of genetic associations 1/6
DeepNull: Modeling non-linear covariate effects improves phenotype prediction and association power biorxiv.org/cgi/content/shor… #bioRxiv
Taiwan biobank 🇹🇼 - adding diversity to East Asian genetics research
A large-scale genomics resource of East Asian ancestry made available by Taiwan Biobank. A joint project with @ChiayenChen @DrYenFengLin @getian107 @AnnejaneF @dalygene and many others!
Anne Feng retweeted
Precision medicine in 2030—seven ways to transform healthcare from @NIHDirector @AllofUsCEO cell.com/cell/fulltext/S0092…
Anne Feng retweeted
On behalf of the Bipolar Exome (BipEx) project, I'm excited to present our analyses of exome sequencing data from 13,933 bipolar disorder cases and 14,422 controls which highlights AKAP11 as a shared risk gene with schizophrenia: medrxiv.org/cgi/content/shor… (1/9)
Anne Feng retweeted
Exciting day for COVID-19 host genetics! 🧬🎊
1) Flagship @covid19_hgi paper. Largest GWAS for COVID-19. 50000 cases. 15 loci
medrxiv.org/content/10.1101/…
2) The clinical impact of the strongest genetic variant for COVID-19 and its age-dependent effect.
medrxiv.org/content/10.1101/…
Anne Feng retweeted
This paper was a longtime coming. In no particular order, some of the interesting things to learn from the sequencing and analysis of 53,831 human genomes. 1/n
nature.com/articles/s41586-0…
PDF: nature.com/articles/s41586-0…
Anne Feng retweeted
Pleased to share a new preprint- we extended PRS-CS to PRS-CSx which can integrate GWAS summary statistics from multiple populations to improve cross-population polygenic prediction: medrxiv.org/content/10.1101/…
Large-scale machine learning-based phenotyping
significantly improves genomic discovery for optic
nerve head morphology
arxiv.org/ftp/arxiv/papers/2…
Anne Feng retweeted
In a major scientific breakthrough, the latest version of #AlphaFold has been recognised as a solution to one of biology's grand challenges - the “protein folding problem”. It was validated today at #CASP14, the biennial Critical Assessment of protein Structure Prediction (1/3)
Excited to share our new preprint! We looked deep into the genetic architecture of age of first occurrence and characterized its genomic relationship with disease susceptibility. Many thanks to my awesome mentors and collaborators @jorsmo @bmneale @getian107 @andganna @bordinki
Findings and insights from the genetic investigation of age of first reported occurrence for complex disorders in the UK Biobank and FinnGen medrxiv.org/cgi/content/shor… #medRxiv
Anne Feng retweeted
For those new to writing grants, these @NIH (in this case @genome_gov) Strategic Vision documents are *extremely* helpful. Understanding intermediate-term goals can help align your research agendas/trajectories. nature.com/articles/s41586-0… @nature @NHGRI_Director #Genomics2020
After several years of hard work, including discussions with thousands of people in the US and abroad, @genome_gov is proud to share our #Genomics2020 Strategic Vision with you! The official paper is now published in @Nature. go.nature.com/31MUSG3
