Microbial immunity, genetics, genomics, evolution @institutpasteur. Group leader @Mdmlab_paris Activist for more inclusive sciences
Paris, France
Joined September 2011
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Join us in Paris on April 8th-10th for the 2025 Symposium on the Immune System of Bacteria 🥖🍷🦠🧬.
Excited to welcome these amazing speakers at @institutpasteur .
Registration will open beginning of November. Abstract deadline February 28. Stay tuned.
Aude Bernheim retweeted
🌟👏 Félicitations à Aude Bernheim @AudeBer, lauréate du Prix Irène Joliot-Curie dans la catégorie « Jeune femme scientifique » pour ses travaux sur l'immunité bactérienne et son rôle dans la défense antivirale et l'immunité humaine.
ALT Ces 5 dernières années, le travail d’Aude Bernheim, parmi d’autres, a contribué à révéler l’existence de centaines nouveaux systèmes bactériens et de nombreux nouveaux mécanismes de cette immunité ancestrale, offrant une vision renouvelée de l’immunité et des perspectives thérapeutiques innovantes. ©Institut Pasteur
Aude Bernheim retweeted
Our latest #Ichthyosporean #EvoDevo story, led by M. Olivetta @ChandniBhickta @NChiaruttini & in co. with
@burnsajohn is finally out @Nature .
Link⏩: nature.com/articles/s41586-0…
Preprint⏩: biorxiv.org/content/10.1101/…
1/5)
Aude Bernheim retweeted
OUT NOW 🦠 Prediction of strain level phage-host interactions across the Escherichia genus using only genomic information, by @AudeBer @hugovaysset @MDMlab_Paris @iame_center @PhagePasteur
nature.com/articles/s41564-0…
Aude Bernheim retweeted
Super important! Receptors matter!
OUT NOW 🦠 Prediction of strain level phage-host interactions across the Escherichia genus using only genomic information, by @AudeBer @hugovaysset @MDMlab_Paris @iame_center @PhagePasteur
nature.com/articles/s41564-0…
Aude Bernheim retweeted
Woohoo, the @AudeBer lab is 🔥 Congrats!!
OUT NOW 🦠 Prediction of strain level phage-host interactions across the Escherichia genus using only genomic information, by @AudeBer @hugovaysset @MDMlab_Paris @iame_center @PhagePasteur
nature.com/articles/s41564-0…
Can i apply? This really sounds like an incredible opportunity.
Fancy a postdoc in Munich? For a collaborative project between @SorekLab and @hornung_lab on antiviral innate immunity, we are looking for exceptional candidates with skills in immunology / biochemistry / computational biology. More details here:
genzentrum.uni-muenchen.de/c…
Aude Bernheim retweeted
🚨 New preprint alert! 🚨 We're excited to share our latest work: "Towards a complete phage tail fiber structure atlas" 🦠🔬 of first author @VKleinSousa
We developed #RBPseg for segmenting and merging phage tail fibers using structural prediction tools.
tinyurl.com/58cn2ew7
Aude Bernheim retweeted
Absolutely thrilled to share our new study, co-led by @PujaMajumder91 and myself, now online in @CellCellPress! Here, we characterize a CRISPR-associated adenosine deaminase, Cad1. Incredibly grateful for @MarraffiniLab making it possible. Synopsis below:
cell.com/cell/fulltext/S0092…
Aude Bernheim retweeted
Did you know that bacteria remember their past for many generations? In this new preprint from us (@VillaniAlexis and Senen Mendoza) and Banin lab (@ShmidovE ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. biorxiv.org/content/10.1101/…
Aude Bernheim retweeted
We discovered a new immune signaling molecule: N7-cADPR
N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection
Preprint: biorxiv.org/cgi/content/shor…
Congrats @FrancoisRousset & @IlyaOsterman
Aude Bernheim retweeted
I am excited to share our work "Systematic discovery of antibacterial and antifungal bacterial toxins" that is published in @NatureMicrobiol
nature.com/articles/s41564-0…
Aude Bernheim retweeted
🦠🧬Our paper is live @CellCellPress: Genome integrity sensing by the broad-spectrum Hachiman antiphage defense complex
authors.elsevier.com/sd/arti…
Through structural, genetic and microbiological approaches, we show that Hachiman degrades DNA… by sensing low integrity DNA.
Aude Bernheim retweeted
Yasmine Belkaid : "Couper encore plus le budget de la recherche, c'est irresponsable".
À l'occasion du #Pasteurdon", la directrice générale de l'Institut Pasteur était l'invitée de @LeaSalame et @ndemorand sur @franceinter.
Entretien intégral radiofrance.fr/franceinter/p…
Aude Bernheim retweeted
Fellow microbial immunity, mobile elements, and plasmid enthusiasts: the paper of our wonderful @BruriaSamuel on anti-defense genes in plasmids is now published in @Nature!!!
Check out her thread below for highlights of our new results.
1/2
Meet The Shielded Plasmid🛡️🧬
Our new @Nature paper reveals how plasmids outsmart bacterial defenses during conjugation.
It's all about being in the right place at the right time! The positioning of anti-defense genes boosts transfer efficiency🧵(1/7) nature.com/articles/s41586-0…
ALT Illustrated by @Irisburstein
Aude Bernheim retweeted
Meet The Shielded Plasmid🛡️🧬
Our new @Nature paper reveals how plasmids outsmart bacterial defenses during conjugation.
It's all about being in the right place at the right time! The positioning of anti-defense genes boosts transfer efficiency🧵(1/7) nature.com/articles/s41586-0…
ALT Illustrated by @Irisburstein
Aude Bernheim retweeted
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
On the cover: mechanism of bacterial antiphage systems encoding reverse transcriptases , a beautiful exception to the central dogma. Congrats to the authors for these 2 wonderful studies.
Much more incredible molecular biology to uncover in the hundreds of antiphage systems!
The central dogma of molecular biology states that genetic information flows from DNA and RNA to protein, with reverse transcription converting RNA to DNA.
In the pursuit of understanding how bacteria defend themselves from viral infection, two groups have found alternative pathways to making genes from RNA that did not previously encode proteins. Learn more this week in Science: bit.ly/3ZO7tI1
Aude Bernheim retweeted
Our NAD-reconstitution story is finally published in @nature
rdcu.be/dU5AQ
Thank you to all co-authors, especially to @hadarsamra, @FrancoisRousset, Elena Loseva, @ErezTzvi, @AdiMillman, and everybody in the @SorekLab for their help and support.
"Little pigeons can carry great messages🕊️" Phages produce NAD+ by one-step reactions from nicotinamide (all other organisms need at least two) and protect themselves against multiple bacterial immune systems.
Check out our new preprint -
biorxiv.org/content/10.1101/…
A thread below⬇️
Incredible story highlighting the biochemical innovations hiding in phages genomes and revealed by the study of phage-bacteria interactions.
Our paper out today @nature: phages reconstitute NAD+ to counter bacterial immunity
Phaged invented a new biochemical pathway for NAD+ synthesis - including previously unknown enzymatic reactions - to evade bacterial defenses
Congrats @IlyaOsterman!
nature.com/articles/s41586-0…
