boldstart ventures

#1 out of 27. Systalyze is now the fastest GLM 5.3 provider on @ArtificialAnlys, ahead of @inco_ai, @baseten, @togethercompute, and @Zai_org own endpoint. Try it: console.systalyze.com

It’s almost incomprehensible how wide the distance is between someone who’s working at the frontier with AI and basically everyone else right now. The crazy thing is these lines are not converging, but only growing farther apart. If the curve of AI progress had leveled off, it would certainly have given most people and companies time to catch up or implement their workflows in a standardized way. The technology would have neutralized competitive advantage because everyone would be using it the same way. But what’s happened is the opposite. The curve of AI progress is basically going vertical right now, which means if you had codified your processes 3-6 months ago you’re likely already behind again. Now imagine most companies that kicked into gear a year ago and thought that they were done. Even further behind now. I’ve never seen a technology in my life and career that improves at this rate, which consequently means you need to upgrade your expectations at a similar rate. Our brains weren’t wired for this, and our organizational change management processes certainly weren’t either. With any form of recursive self improvement, things just get wilder. It’s a time when you will need to be constantly reevaluating the things that didn’t work just a couple months ago to see if they now can be solved. AI native companies certainly have a strong advantage due to this right now, so now it comes down to can the bigger companies keep up. Wild times.

I invented the chat window for business in 1997 at LivePerson. 29 years later, I'm trying to kill it. Because the best interface to AI was never a chat box. It's you. $10.3M raised for humans to be AI-native and authentic. The most valuable dataset in AI is you. You should own it.

the white house just declared our dependence on imported robots and industrial machinery a national security threat. no new tariffs yet. trade negotiations come first. the bigger point: rebuilding american industry means building the machines that make everything else.

@systalyze is #1 in output speed on @ArtificialAnlys for GLM 5.2, in both reasoning and non-reasoning modes. → 538 tok/s: 1.7× faster than @baseten and @CoreWeave , 5.5× @Zai_org own endpoint → Cheapest provider on non-reasoning Try it: console.systalyze.com

Topos Bio CEO Ryan Zarcone explains why designing drugs for Parkinson's and Alzheimer's is almost impossible for humans, but a perfect problem for AI: "When a chemist designs a drug for a protein, the model is static. I have this protein, it has a shape, and I’m trying to fill that shape with a drug." "These really dynamic proteins, like those involved in Parkinson’s and Alzheimer’s, don’t have one shape. They have potentially thousands of different shapes that they’re constantly interconverting between, kind of like someone who’s dancing." "That becomes basically impossible when you tell a human, design something for these thousand things at the same time. It’s really only been possible to start doing that with AI." @ToposBio

SCOOP: Major U.S. banks are detecting unauthorized third-party AI agents inside customer accounts, including some attempting to take actions that appear to be independent of user instructions, sources told Axios. The findings have alarmed banking executives, who are racing to restrict access to their systems as AI moves at a velocity faster than financial institutions can respond, multiple industry and bank executives told Axios. Several banks are now preparing for worst-case and even “day after” scenarios, including how to rapidly secure or restore customer accounts if things go wrong, the people said. Several bank executives told Axios they're struggling to distinguish between human users and AI agents. One executive said banks also struggle to determine whether agents are authorized by customers or potentially operating without their permission, more akin to rogue agent behavior. Read my latest for Axios here: axios.com/2026/10/22/ai-agen…