Buckanovich Lab (@BuckanovichLab) profile picture

Buckanovich Lab

@BuckanovichLab

Our lab develops new therapies for ovarian cancer, focusing on quiescent CSC & the immune tumor microenvironment @MageeWomens @UPMCHillmanCC

 Pittsburgh PA
mageewomens.org/investigator/ronald-john-buckanovich-md-ph-d
Joined November 2021
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  • Following38
  • Followers116
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Photo by Buckanovich Lab (@BuckanovichLab)Photo by Buckanovich Lab (@BuckanovichLab)Photo by Buckanovich Lab (@BuckanovichLab)
Shifting some of our focus to endometrial cancer. authors.elsevier.com/a/1ickg…
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Former Damon Runyon Clinical Investigator @BuckanovichLab and his team set out to understand why only some ovarian cancer patients respond favorably to immune checkpoint inhibitors, and found that the answer lay in the tumor microenvironment. Learn more: bit.ly/3uveOg3
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What if we could prevent the recurrence of #ovariancancer? Through critical research, Magee-Womens Research Institute investigators like Dr. Ronald Buckanovich are giving women with cancer new hope. #OvarianCancerAwarenessMonth Make a gift today: bit.ly/3BwtoWA
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JCI Insight - Phase I trial of ribociclib with platinum chemotherapy in recurrent ovarian cancer insight.jci.org/articles/vie…
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A very nice clinical trial from Dr. Lan Coffman
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#coffman, #upmchcc
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I'm supporting National Ovarian Cancer Coalition! do.nr/n0ptze via @DonorDrive
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Targeting therapeutic resistance and multinucleate giant cells in CCNE1-amplified HR-proficient ovarian cancer aacrjournals.org/mct/article… A potential new therapeutic approach for women with hard to treat CCNE1 amplified tumors.
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authors.elsevier.com/a/1eY3q… Another interesting paper linking metformin therapy and cancer outcomes.
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First patients of pioneering CAR T-cell therapy ‘cured of cancer’ theguardian.com/society/2022…

First patients of pioneering CAR T-cell therapy ‘cured of cancer’

Cancer-killing cells still present 10 years on, with results suggesting therapy is a cure for certain blood cancers

theguardian.com
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Updated perspective on the Hallmarks of Cancer: New Dimensions | Cancer Discovery #cancer #cancerresearch #oncology #science cancerdiscovery.aacrjournals…
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Buckanovich lab is helping to support MWRI's important efforts to facilitate under-represented minorities on a path in science donorbox.org/m3s3
MWRI Members’ Minority Student Summer Scholarship (M3S3) | Magee-Womens Research Institute &...

MWRI Members’ Minority Student Summer Scholarship (M3S3) | Magee-Womens Research Institute &...

It is key that we ensure that the future leaders in the field of women’s health are as diverse as the women who will rely on them for hope through innovative medical research.MWRI Members’ Minority...

donorbox.org
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Celebrating the holidays with a multinational food potluck! Amazing food and people - including our newest (4wk old) lab member.

ALT Celebrating the holidays with a multinational food potluck! Amazing food and people - including our newest (4wk old) lab member.

Image from Buckanovich Lab (@BuckanovichLab)
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Celebrating the holidays with a multi-national potluck-- Yumm!
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Buckanovich Lab retweeted
Vignali Lab (@Vignali_Lab) profile picture
Vignali Lab@Vignali_Lab8 Dec 2021
Very excited to share our latest paper in @ScienceTM co-led with @BcellBruno on the prevalence of intratumoral Tregs expressing NRP1 and their association with poor outcome in cancer patients. Kudos to my grad student Chris Chuckran who led this study! science.org/doi/10.1126/scit…
Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer...

Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer...

Persistent T cell receptor stimulation drives neuropilin-1 on intratumoral regulatory T cells, which is associated with poor clinical outcome.

science.org
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.@KellyLeonPSU et al. @airdlab demonstrate that DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A. bit.ly/36vfSn1 Part of the Year in Cell Biology: 2021 bit.ly/3rtllGF #CellBio2021
Image from Journal of Cell Biology (@JCellBiol)
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Buckanovich Lab retweeted
Tina's Wish (@TinasWish) profile picture
Tina's Wish@TinasWish17 Nov 2021
It's important to be aware of the signs & symptoms of #OvarianCancer like bloating, upset stomach, frequent urination, feeling full quickly & pelvic pain. Contact your doctor if these symptoms persist for 2+ weeks. Read @Kandigyrl3's full story at tinaswish.org/kandis-draw/
Image from Tina's Wish (@TinasWish)
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Buckanovich Lab retweeted
Ronny Drapkin (@ronny_drapkin) profile picture
Ronny Drapkin@ronny_drapkin18 Nov 2021
Ask Congress to Increase Funding for Ovarian Cancer Research and Enact FY 2022 Spending Bills! votervoice.net/Shares/BAAAAA… @BasserBRCA @NOCC_National @RivkinCenter @TinasWish @ocrahope
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Super excited about a new study we published today. This work shows CA-MSC are driving tumor immune exclusion and resistance to immune therapy. This study supports a new clinical trial we will launch in the spring! science.org/doi/10.1126/scia…
Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be...

Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be...

HHi reverses the CA-MSC driven tumor immune cell exclusion restoring the response to ICI.

science.org
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Buckanovich Lab retweeted
Thomas Mace, Ph.D. (@TMaceLab) profile picture
Thomas Mace, Ph.D.@TMaceLab12 Nov 2021
Congrats to Dr. Lotze for his @sitcancer 2021 lifetime achievement award. @TRCCC1998
Image from Thomas Mace, Ph.D. (@TMaceLab)
Image from Thomas Mace, Ph.D. (@TMaceLab)
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