Chris Horne (@ChrisH_NZ) header
Chris Horne (@ChrisH_NZ) profile picture

Chris Horne

@ChrisH_NZ

🇳🇿 Kiwi biochemist working on Kinases and Pseudokinases @WEHI_research | @WEHI_Postdocs | Up the Wahs!

Joined August 2016
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Photo by Chris Horne (@ChrisH_NZ)Photo by Chris Horne (@ChrisH_NZ)Photo by Chris Horne (@ChrisH_NZ)Photo by Chris Horne (@ChrisH_NZ)Photo by Chris Horne (@ChrisH_NZ)Photo by Chris Horne (@ChrisH_NZ)Photo by Chris Horne (@ChrisH_NZ)Photo by Chris Horne (@ChrisH_NZ)Photo by Chris Horne (@ChrisH_NZ)Photo by Chris Horne (@ChrisH_NZ)
Chris Horne retweeted
James Murphy (@pseudokinase) profile picture
James Murphy@pseudokinaseAug 28
Great to see this out. Congrats to our wonderful team
WEHI (Walter and Eliza Hall Institute) (@WEHI_research) profile pictureWEHI (Walter and Eliza Hall Institute)@WEHI_researchAug 27
Uncovered: early molecular warning signs of inflammatory bowel disease reveal the condition can begin before symptoms appear and continue silently even when patients appear well. Published in @ScienceMagazine. 🔗wehi.edu.au/news/researchers…
Image taken through spatial transcriptomics showing patterns of cell death-related genes in gut tissue from people with inflammatory bowel disease. The headline reads "The 'smouldering' defect behind inflammatory bowel disease flare-ups"

ALT Image taken through spatial transcriptomics showing patterns of cell death-related genes in gut tissue from people with inflammatory bowel disease. The headline reads "The 'smouldering' defect behind inflammatory bowel disease flare-ups"

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The countdown is on for our third symposium... MELBR 2025 SYMPOSIUM - collaborate and elevate! Join us 11 Sept for our 1-day event, 9.30am-3.45pm, Parkville, Melbourne 🧬🔬💊💉❤️‍🩹 Abstract submissions due 1 August: melbr.org/symposium-2025.htm…
Image from Melbourne Emerging Leaders in Biomedical Research (@MelbourneELBR)
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Glad to share my cover art for the Feb 2025 issue of @TrendsBiochem. Check out our review in "Protein shapeshifting in necroptotic cell death signalling" with @pseudokinase @AndreSamson15 and Wayne Cawthorne cell.com/trends/biochemical-…
Image from Hanadi Hoblos (@HanadiHoblos)
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Glad to see this out😄 With Wayne Cawthorne, @AndreSamson15 & @pseudokinase Looking forward to seeing more discoveries of how PTMs regulate protein shapeshifting during necroptotic cell death ☠️ Check it out here 👇 doi.org/10.1016/j.tibs.2024.…
Trends in Biochemical Sciences (@TrendsBiochem) profile pictureTrends in Biochemical Sciences@TrendsBiochem2 Jan 2025
Available online - the Review "Protein shapeshifting in #necroptotic cell death signaling" from @pseudokinase and colleagues. #programmedcelldeath #kinase #pseudokinase #phosphorylation #proteinconformation Read it here 👉 authors.elsevier.com/a/1kKdt…
Image from Trends in Biochemical Sciences (@TrendsBiochem)
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Check out our latest from @WEHI_research A joint effort with James Vince’s lab and our RMH colleagues. Super proud of this epic built on ~1100 western blots. Full credit to the leads, Jiyi Pang and Aysha Al-Ani, our collaborators, and my coconspirators including @AndreSamson15
bioRxiv Cell Biology (@biorxiv_cellbio) profile picturebioRxiv Cell Biology@biorxiv_cellbio13 Nov 2024
A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease biorxiv.org/cgi/content/shor… #biorxiv_cellbio
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Very proud & excited to be socialising our preprint uncovering new mechanisms of epithelial cell death in IBD! Massive 4-year collab across @WEHI_research & @RMH. Big thanks to the patients involved in this study and support from @NHMRC & @KR_Foundation biorxiv.org/content/10.1101/…
A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with IBD receive therapy to...

biorxiv.org
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Hot off the press! 🔥 In our latest @NatureComms paper, we used in vivo imaging to track EV formation in the bone marrow microenvironment. We found that circulating EVs correlates with tissue damage caused by leukemias like AML! @WEHI_research @latrobe @AusCellDeathSoc
WEHI (Walter and Eliza Hall Institute) (@WEHI_research) profile pictureWEHI (Walter and Eliza Hall Institute)@WEHI_research28 Oct 2024
Researchers have made a critical discovery that could help develop a future blood test to potentially monitor the level of tissue damage in patients with diseases like #cancer. wehi.edu.au/news/cellular-co… 🧵1/2
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Pleased to see this work in the wild… watch this space for more on CAMK signalling!
James Murphy (@pseudokinase) profile pictureJames Murphy@pseudokinase25 Oct 2024
Delighted to present 2 preprints with my co-captains @ChrisH_NZ @Dr_CaMKkinase We tell you everything you thought about CaM regulation of CAMK kinases might need a rethink biorxiv.org/content/10.1101/… biorxiv.org/content/biorxiv/… Thanks a million to our amazing Coconspirators
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#MELS2024 That's a wrap!! Thanks to all our sponsors, delegates, speakers, poster presenters, panel members, judges, and vendors! We all had a great day. See you for an even bigger one in 2025!!
Image from Melbourne Emerging Leaders in Biomedical Research (@MelbourneELBR)
Image from Melbourne Emerging Leaders in Biomedical Research (@MelbourneELBR)
Image from Melbourne Emerging Leaders in Biomedical Research (@MelbourneELBR)
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After our inaugural symposium and official launch of the Melbourne Emerging Leaders in Biomedical Research Society in 2023, we are excited to announce our networking symposium will be back later this year Look out for abstract submission and registration very soon! 🔬 🧬
Melbourne Emerging Leaders in Biomedical Research (@MelbourneELBR) profile pictureMelbourne Emerging Leaders in Biomedical Research@MelbourneELBR7 May 2024
Save the date for our 2nd Melbourne Emerging Leaders in Biomedical Research symposium! 18 Sept 2024. Keep your eyes peeled for registration, and more on our program and sponsors 👀👀
Image from Melbourne Emerging Leaders in Biomedical Research (@MelbourneELBR)
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Incredibly relieved, overwhelmed and grateful to be awarded an NHMRC EL1 Fellowship to accelerate my work on calcium signalling and kinase regulation Huge thanks to my mentor @pseudokinase and all the other legends for their support @WEHI_research, @MIPS_Australia & @dobson_lab
WEHI (Walter and Eliza Hall Institute) (@WEHI_research) profile pictureWEHI (Walter and Eliza Hall Institute)@WEHI_research2 May 2024
Massive congratulations to all the recipients of @NHMRC Investigator Grants, including our 17 remarkable researchers who are leading innovative projects covering malaria, blood cancer, the ubiquitin system, Parkinson's disease, brain cancer and beyond. 🧵1/4
Image from WEHI (Walter and Eliza Hall Institute) (@WEHI_research)
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Biomolecular Horizons 2024. Join this amazing line up of speakers. Abstracts due 12 March 2024. bmh2024.com/call-for-abstrac… . @bmh2024Melb, a joint conference of @IUBMB, #FAOBMB & #ComBio in Melbourne 22-26 September 2024.
Image from Biomolecular Horizons 2024 (@bmh2024Melb)
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A mammoth and incredibly important piece of work for the field. Top stuff Shene Chiou, @aysha_h_alani @AndreSamson15 🔬
Andre Samson (@AndreSamson15) profile pictureAndre Samson@AndreSamson152 Nov 2023
Excited to share our preprint that spatially profiles the necroptotic cell death pathway in mouse and human tissues. With @pseudokinase + @WEHI_research we pinpoint necroptotic changes during inflammation, dysbiosis, immunisation and in IBD patients! biorxiv.org/cgi/content/shor…
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Fantastic work Michael Currie, @_jamesdavies, @rachel_a_north and @dobson_lab 💪
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Awesome to see this story out! Congrats @YanxiangMeng and @SarahGarnish for steering the ship on this project. Was nice to contribute
WEHI (Walter and Eliza Hall Institute) (@WEHI_research) profile pictureWEHI (Walter and Eliza Hall Institute)@WEHI_research27 Oct 2023
Researchers have gained unprecedented insight into how a ‘killer’ protein is unleashed during a form of programmed #celldeath. Brilliant research led by @YanxiangMeng and @SarahGarnish from the lab of @pseudokinase, published in @NatureComms. More: nature.com/articles/s41467-0… 🧵1/3
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Make sure you lock in this awesome conference in 2024 and sign up to the career development forum if you are an ECR
Biomolecular Horizons 2024 (@bmh2024Melb) profile pictureBiomolecular Horizons 2024@bmh2024Melb6 Oct 2023
Join the global scientific community at Biomolecular Horizons in Melbourne in September 2024 and submit an abstract to contribute to this important conversation. Visit bmh2024.com for more information #bmh2024
Image from Biomolecular Horizons 2024 (@bmh2024Melb)
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WHY do so many people carry this MLKL polymorphism?!🧐 Heart-felt thanks to the brilliant @SarahGarnish, Kate Martin, Maria Kauppi, @pseudokinase and lab, @WEHI_research, @nhmrc and many more for indulging this burning question over many years. 🔥😅👏 rdcu.be/dndm8
Image from Dr. Joanne Hildebrand (@jo_hildebrand)
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Incredible turnout for our first EMCR event @MelbourneELBR #MELS2023 Thanks to our amazing speakers, generous sponsors and everyone who came along
Image from Chris Horne (@ChrisH_NZ)
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Thrilled to see our vision of an EMCR society within Melbourne begin to flourish at our inaugural event. Thanks to the @MelbourneELBR committee for making it happen. Legends!
Connie Ow, Ph.D (@valliancecon) profile pictureConnie Ow, Ph.D@valliancecon1 Sep 2023
Proud to co-organise the Inaugural 2023 Melbourne Emerging Leaders in Research Symposium @TheFlorey The event provided key insights from career experts and ample networking opportunities for EMCRs across Parkville - the day was buzzing with excitement . @MelbourneELBR
Image from Connie Ow, Ph.D (@valliancecon)
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Today is the day! The inaugural Melbourne Emerging Leaders in Biomedical Research Symposium! Looking forward to a day of thought provoking science 👩🏼‍🔬 @MelbourneELBR @PMPostdocs @MACHAustralia #postdocs #postdocsymposium #mels2023
Image from Kirstyn Carey (@kirstyn_carey)
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