Christian Peace (@ChristianGPeace) header
Christian Peace (@ChristianGPeace) profile picture

Christian Peace

@ChristianGPeace

Postdoc in the Rabinowitz lab @Princeton

 Princeton, NJ
Joined June 2019
  • Tweets167
  • Following767
  • Followers319
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Photo by Christian Peace (@ChristianGPeace)Photo by Christian Peace (@ChristianGPeace)Photo by Christian Peace (@ChristianGPeace)Photo by Christian Peace (@ChristianGPeace)
Excited to share a new paper from my PhD work along with @shaneOCarroll4 from the @laoneill111 lab on how the metabolite itaconate regulates IFN, out today in @NatMetabolism (nature.com/articles/s42255-0…) (1/n)
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🚨 Excited to share our new paper is out in Nature! 🔗 Reprogramming neuroblastoma by diet-enhanced polyamine depletion nature.com/articles/s41586-0…
Reprogramming neuroblastoma by diet-enhanced polyamine depletion

Reprogramming neuroblastoma by diet-enhanced polyamine depletion

Nature - Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle...

nature.com
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Christian Peace retweeted
Asael Roichman (@AsaelRoichman) profile picture
Asael Roichman@AsaelRoichman19 May 2025
Thrilled to share that my main postdoctoral project in Josh Rabinowitz’s lab is out today at @CellCellPress! We found an unexpected, diet- and microbiota-dependent mechanism that affects the anticancer activity of PI3K inhibitors. Thread below👇
Image from Asael Roichman (@AsaelRoichman)
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Tony Hui (@realTonyHui) profile picture
Tony Hui@realTonyHui20 Feb 2025
Happy to share the final version of this work where we incorporated isotope labeled CO2 data into mass spec-based flux analysis framework to build a whole-body flux model of energy metabolism. Full article access here: authors.elsevier.com/a/1keM5… @yuanbogeneral
Tony Hui (@realTonyHui) profile pictureTony Hui@realTonyHui13 Feb 2024
Happy to share a preprint on our effort of building whole-body flux models. We integrated the key organismal metabolic parameter CO2 production rate and also its isotope labeling into the in vivo isotope tracing framework.
Image from Tony Hui (@realTonyHui)
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Won Dong Lee (@Won_Dong_Lee) profile picture
Won Dong Lee@Won_Dong_Lee30 Jan 2025
Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Today in @Cell_Metabolism, we uncover key mechanisms of lactate homeostasis. sciencedirect.com/science/ar…
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Dylan Ryan (@RyanLab_TCD) profile picture
Dylan Ryan
@RyanLab_TCD6 Jan 2025
📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc @EloiseMLMrqs. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n biorxiv.org/content/10.1101/…
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo

An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo

Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses[1][1]–[6][2], but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we...

biorxiv.org
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Thrilled to share our approach for language model-guided discovery of unknown mammalian metabolites: DeepMet. We’ve now used this approach to discover ~50 new human and mouse metabolites! biorxiv.org/content/10.1101/…
Language model-guided anticipation and discovery of unknown metabolites

Language model-guided anticipation and discovery of unknown metabolites

Despite decades of study, large parts of the mammalian metabolome remain unexplored. Mass spectrometry-based metabolomics routinely detects thousands of small molecule-associated peaks within human...

biorxiv.org
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Long Lab (@longlabstanford) profile picture
Long Lab@longlabstanford12 Nov 2024
Today in @CellCellPress we report a new pathway of ketone metabolism. This BHB shunt generates an orphan family of anorexigenic ketone metabolites that are chemical cousins of exercise-inducible Lac-Phe. Congratulations @mariadolores_mg @Stanford_ChEMH cell.com/cell/fulltext/S0092…
A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites

A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites

Conserved ketone body-amino acid metabolites suppress food intake in mice, demonstrating that secondary ketone body metabolism contributes to energy balance.

cell.com
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Luke O'Neill (@laoneill111) profile picture
Luke O'Neill@laoneill11116 Oct 2024
Big congrats to Shane O’Carroll and Christian Peace who led this study in our lab- a metabolite called Itaconate already known to be anti- inflammatory also drives anti-viral interferons via blocking the enzyme SDH. Funded by the ERC and Research Ireland tcd.ie/news_events/articles/…
Image from Luke O'Neill (@laoneill111)
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Ivan Zanoni (@Lo_Zanzi) profile picture
Ivan Zanoni
@Lo_Zanzi15 Oct 2024
#ImmunometabolismPower! @ChristianGPeace @shaneOCarroll4 @laoneill111 &co show @NatMetabolism that itaconate drives type I #interferons by inhibiting SDH & driving #mitochondrial RNA release via VDAC1, thus activating RIG-I/MDA5! nature.com/articles/s42255-0…
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@anne_swim, Maureen O'Sullivan, Loius Kehoe, Neali Armstrong, @EmDay4, and my mentor @laoneill111!
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Finally, we would like to thank all of the reviewers and the team at @NatMetabolism for a fruitful and productive process!
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Christian Peace retweeted
Dylan Ryan (@RyanLab_TCD) profile picture
Dylan Ryan
@RyanLab_TCD24 Jul 2024
Two fascinating papers on mitochondrial respiratoty chain complexes and microglial function @NatMetabolism #immunometabolism ⬇️⬇️⬇️ I) nature.com/articles/s42255-0… II) nature.com/articles/s42255-0… With a great news and views on both studies by @Pluchinolab nature.com/articles/s42255-0…
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