Affiliated with @StanfordPath and @Stanford_ChemH. We study mammalian energy metabolism!
Palo Alto, CA
Joined February 2018
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Long Lab retweeted
Our @Nature paper is out!
It's been known for a while that long-term dietary habits can affect how our immune system behaves. But what about much briefer changes in diet?
In mice, we found that even a few days of dietary change (think cheat days...or perhaps salad Sundays) at the onset of inflammation can profoundly alter disease severity and establish lasting inflammatory memory in tissues, even after the diet changes back.
nature.com/articles/s41586-0…
This work was led by two extraordinarily dedicated and inexhaustible members of our lab: former graduate student @OwenJ457 and former technician John Tayeri. It was also an exercise in collaborative science as many labs @UCSF and @Stanford came together to bring this over the finish line - special thanks to @gardnerlabUCSF, @Molofsky_lab, @alexis_combes, @Treg_Mike. Deeply grateful to everyone who contributed!
A pretty interesting experiment - engineering a metabolic bypass of mitochondria pyruvate uptake. Good to see that the expected cellular effects match w what would be generally expected from such a system
Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells
nature.com/articles/s41589-0…
A big thank you to Leslie Leinwand lab for hosting @Shuke_Xiao @ssiipei this week @CUBoulder. Learning more about 🐍 husbandry to get our own colony up and going @Stanford_ChEMH
Delighted to spend today with the amazing Team FEAST and @rushika_perera @Stanford @UCSF- dissecting the effects of diet, obesity, and GLP1 medicines in pancreatic cancer. @SCIDirector @Ashworth_SF
Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung!
cell.com/cell/fulltext/S0092…
Now kicking off CRB60 is co-organizer @basktastic highlighting what I also agree is one of Carolyn’s most important contribution to science- her impact as a mentor and advisor @Stanford_ChEMH @Stanford
So excited for today CRB60 symposium, 350+ alumni friends and colleagues here @Stanford_ChEMH @Stanford to celebrate Carolyn
Lac-Phe is an exercise💪 and metformin💊 inducible blood-borne metabolite that suppresses appetite. How does Lac-Phe get into circulation? New from @Shuke_Xiao: a transporter deorphanization story that links local cellular metabolism to systemic activity:
biorxiv.org/content/10.64898…
Long Lab retweeted
Join us for the CRB60 Symposium, celebrating our director Carolyn Bertozzi's legacy and impact on chemical biology, with talks from her lab alumni!
Oct 9, 2026, Paul Berg Auditorium, Stanford.
Register here: brnw.ch/21x64tQ
@UCB_Chemistry
ALT Speakers: Nicholas Agard • Genentech Steven Banik • Stanford Michael Boyce • Duke Xing Chen • Peking University Penelope Drake • 16 Waves Danielle Dube • Bowdoin Ryan Flynn • Harvard Zev Gartner • UCSF Howard Hang • Scripps Matt Hangauer • UC San Diego Ramesh Jasti • Oregon Jennifer Kohler • UTSW Jessica Kramer • Utah Lara Mahal • Alberta Stacy Malaker • Yale Lisa Marcaurelle • GSK Matthew Pratt • USC Jennifer Prescher • UCI Benjamin Schumann • TU Dresden Sloan Siegrist • UMass Amherst Ellen Sletten • Dartmouth David Vocadlo • Simon Fraser Christina Woo • Harvard Peng Wu • Scripps
A very interesting concept... would love for all papers to be more interactive- and more standardized (!) along the way
Thrilled that #paper2agent is published in @nature today!
Scientific knowledge is traditionally stored in passive papers. Paper2Agent transforms papers into virtual authors that answer questions, apply its methods and collaborate w/ other paper agents to make new discoveries 🧵
Another year, another BAMM! @SvenssonLab @StanfordPath @StanfordDRC Looking forward to a full day of great talks 💪💪 @ishahjain @rushika_perera @RobertoZoncu @MaayanLevyPhD
Had a fun time chatting about peptides and pythons with Australia’s @DavidWoiwod and Monique. Live from the @sunriseon7 Melbourne studio- full interview here: youtu.be/1O_0DJHiGxo?is=aAYi…
Speaking now @AUDiabetesSoc, @SvenssonLab presents the latest on her lab’s work in new peptide discovery @StanfordMed @StanfordPath
A remarkably fast timeline:
2022: our lab @veronical1411 first discovers Lac-Phe as an exercise-inducible anorexigenic metabolite
2024: @Shuke_Xiao @lynchielydia Lac-Phe also mediates metformin-associated weight loss
2026: an oral Lac-Phe mimetic in human completes phase 1 trial
Read more in @statnews's coverage about ENV-308, our second clinical-stage molecule to clear Phase 1 and the first drug ever tested in humans designed to harness the effects of exercise: statnews.com/2026/08/18/enve…
#Enveda #ExercisePill #LearningFromLife #PRISM
Reporting out today- Phase 1 clinical data, oral Lac-Phe mimetic ENV-308 from @enveda. No safety signals (good) and some changes in other biomarkers including leptin (!)… Phase 2 trials planned in for weight maintenance. @statnews statnews.com/2026/08/18/enve…
Long Lab retweeted
Our collaborative effort to develop tools for mapping the secretomes of rare cell types in complex tissues is now out @CellRepMethods @longlabstanford @JayarajRajagop2. Congratulations @GShipkovenska @LyuXuchao
cell.com/cell-reports-method…
