Spiegelman Lab (@LabSpiegelman) header
Spiegelman Lab (@LabSpiegelman) profile picture

Spiegelman Lab

@LabSpiegelman

We study metabolic pathways regulating energy homeostasis, mitochondrial biogenesis, and muscle/adipose biology @DanaFarber @HarvardCellBio

 Boston, MA
spiegelmanlab.dana-farber.org/
Joined May 2021
  • Tweets355
  • Following163
  • Followers4.1K
60Media
Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)
Exercise helps improve depression and anxiety. With the Ben Greenwood lab, we wondered if irisin can help improve depression and anxiety in a rodent model. Yes, it looks promising. Feel free to check our preprint. biorxiv.org/content/10.64898…
Exercise Myokine Irisin Enables Behavioral Stress Resistance in Mice

Exercise Myokine Irisin Enables Behavioral Stress Resistance in Mice

Physical activity produces widespread benefits to physical and mental health, including protection against stress-related behavioral outcomes. However, the peripheral signals through which physical...

biorxiv.org
10
48
3,653
It is always fishing season somewhere in the world! Bruce and Shingo in the Florida Keys!
Image from Spiegelman Lab (@LabSpiegelman)
4
1
59
2,689
@KajimuraLab
1
242
A further point: serious depression is not well treated and is the leading cause of suicide. While exercise is effective for helping mild to moderate depression, we hope that by turning to higher levels of irisin, we can help with more severe disease.
142
Another great annual retreat goes in the books. Our rule is you cant talk about what you work on, and it was so interesting. Props to the lab techs who each gave a great talk. Rockport is so lovely in the spring!
Image from Spiegelman Lab (@LabSpiegelman)
47
2,347
Spiegelman Lab retweeted
Nature Metabolism (@NatMetabolism) profile picture
Nature Metabolism
@NatMetabolismMay 21
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis dlvr.it/TSfYKP
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis

The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis

Nature Metabolism - Exercise-mediated neuroprotection in a mouse model of multiple sclerosis is reduced in mice lacking the irisin-encoding gene, Fndc5, and can be recapitulated by peripheral...

nature.com
1
10
3
39
15,180
It is interesting to note, that much of the effects of irisin can be ascribed to the subsequent production of IL-33 by stromal cells within the adipose tissues. We never imagined such a mechanism in 2012! Big congrats to Mu and Gang for these determined efforts.
26
2,252
When we discovered irisin in 2012 (Bostrom et al), we described its actions in terms of the browning of the white fat and anti-diabetic effects. Here, in collaboration with the Mathis lab, we re-examine this in mechanistic detail. nature.com/articles/s42255-0…

Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells

Nature Metabolism - This study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local...

nature.com
1
30
106
9,830
Lab alums Hage Sprenger and Louisa Grauvogel cut loose at Karneval in Köln!!
Image from Spiegelman Lab (@LabSpiegelman)
5
11
1,229
Last day of fishing is such a bittersweet day!
Image from Spiegelman Lab (@LabSpiegelman)
1
1
24
1,296
Beware of scary scientists on Halloween!
Image from Spiegelman Lab (@LabSpiegelman)
4
5
85
7,480
Here is @Rongtian2's News & Views article: nature.com/articles/s44161-0… @LabSpiegelman @rosenzweig_a
2
12
1,482
Cardiac PGC1a is required for adaptations of the heart to exercise (in mice). A wonderful collaboration with the lab of Tony Rosenzweig. Sumeet is off to start his won lab at UVa (congrats!) nature.com/articles/s44161-0…
3
13
3
81
7,663
The passing Of Dave Mangelsdorf is a terrible loss for his family, friends and the science world. Davo will never be forgotten. 😢 chapelgazette.cfd/david-mang…
Image from Spiegelman Lab (@LabSpiegelman)
7
27
3
130
14,468
Davo was a fantastic cook. This is after our last fishing adventure is June 2025
Image from Spiegelman Lab (@LabSpiegelman)
2
31
2,424
It's not true that Jared Rutter can only do metabolite signaling! @CapeCod Bay
Image from Spiegelman Lab (@LabSpiegelman)
1
4
113
6,107
Matt Gilbert and Krys Seremak cartooning the boss's favorite saying at lab meetings 🤣
Image from Spiegelman Lab (@LabSpiegelman)
2
38
2,351
Spiegelman Lab retweeted
Harvard University (@Harvard) profile picture
Harvard University
@Harvard23 May 2025
Without its international students, Harvard is not Harvard. hrvd.me/IntStudents25t
Supporting Our International Students and Scholars

Supporting Our International Students and Scholars

We have just filed a complaint and a motion for a temporary restraining order will follow. As we pursue legal remedies, we will do everything in our power to support our students and scholars.

harvard.edu
20,048
15,271
3,028
89,227
11,566,183
Another great Spiegelman Lab Retreat goes in the record books. Everybody gives a talk, but it can't be what you work on! Stretch the mind.
Image from Spiegelman Lab (@LabSpiegelman)
3
3
95
6,149
What a great occasion! Our Visiting Student Alex Braunsperger and Paulina Braunsperger-Wasserfurth tie the knot, Bavarian style. Heartly Congrats!
Image from Spiegelman Lab (@LabSpiegelman)
5
51
3,831
Load more