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Spiegelman Lab (@LabSpiegelman) profile picture

Spiegelman Lab

@LabSpiegelman

We study metabolic pathways regulating energy homeostasis, mitochondrial biogenesis, and muscle/adipose biology @DanaFarber @HarvardCellBio

 Boston, MA
spiegelmanlab.dana-farber.org/
Joined May 2021
  • Tweets355
  • Following163
  • Followers4.1K
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Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)Photo by Spiegelman Lab (@LabSpiegelman)
Spiegelman Lab retweeted
Nature Metabolism (@NatMetabolism) profile picture
Nature Metabolism
@NatMetabolismMay 21
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis dlvr.it/TSfYKP
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis

The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis

Nature Metabolism - Exercise-mediated neuroprotection in a mouse model of multiple sclerosis is reduced in mice lacking the irisin-encoding gene, Fndc5, and can be recapitulated by peripheral...

nature.com
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Here is @Rongtian2's News & Views article: nature.com/articles/s44161-0… @LabSpiegelman @rosenzweig_a
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Spiegelman Lab retweeted
Harvard University (@Harvard) profile picture
Harvard University
@Harvard23 May 2025
Without its international students, Harvard is not Harvard. hrvd.me/IntStudents25t
Supporting Our International Students and Scholars

Supporting Our International Students and Scholars

We have just filed a complaint and a motion for a temporary restraining order will follow. As we pursue legal remedies, we will do everything in our power to support our students and scholars.

harvard.edu
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Spiegelman Lab retweeted
11 Yanks (@11Yanks) profile picture
11 Yanks
@11Yanks2 Jul 2024
Hey @ussoccer sponsors. @att @VW @trulyseltzer @Allstate @Nike we are sick and tired of @jtbatson, Cindy Parlowe Cone and Matt Crocker and their love for Gregg Berhalter. We will not accept him staying as USMNT coach & we will not buy your products if you endorse him.
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Online now in @Cell_Metabolism: we discuss regulation of skeletal muscle's adaptation to exercise from a tissue immunology perspective, highlight relevance to disease and aging, & propose avenues for future exploration. authors.elsevier.com/c/1i~Wj…
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Excited to announce I’ve been awarded a T32 fellowship with @BidmcCvi! I’ll continue working in @LabSpiegelman & @GygiLab using proteomics to interrogate inter-organ signaling following exercise. Grateful for this opportunity to join an outstanding cohort & grow as a scientist.
Image from Amanda Smythers, PhD (@AmandaLSmythers)
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Don’t miss Bruce Spiegelman @LabSpiegelman @harvardmed @DanaFarber on PGC1a/Irisin Pathway: Key Effectors Linking Exercise with Cognition and Neurodegeneration. Register by March 1 & save. #Exmet2024 hubs.li/Q02lQ93z0
Image from Cell Metabolism (@Cell_Metabolism)
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Big news for #UMich! 📣 Thrilled to welcome Dr. Jorge Ruas to @UMichMedicine🎉! Jorge brings world-class expertise in metabolism and exercise physiology to @UM_IHBH and @UMPharmacology. Excited for the transformative collaborations ahead!🧬🔬#ScienceInnovation #HealthResearch
Image from Anthony Rosenzweig, MD (@rosenzweig_a)
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Grateful to Dean Klotman, @kcooney1234 @DukeMPI and @dukeendocrinol1 for this tremendous honor. Thankful for the lab members past and present and my former mentors and colleagues @UTSWdiabetes @LabSpiegelman @PennIDOM and @KlausKaestner
Mary E. Klotman, MD (@MaryEKlotman) profile pictureMary E. Klotman, MD@MaryEKlotman6 May 2023
Congratulations to Rana Gupta, professor of @dukemedicine in the Division of Endocrinology, Metabolism, and Nutrition, and a professor in cell biology. He is internationally known for his expertise in metabolic regulation and adipose tissue biology. @DukeGuptaLab
W. David and Sarah W. Stedman Distinguished Professor in the School of Medicine Rana Gupta, PhD Rana Gupta, PhD

ALT W. David and Sarah W. Stedman Distinguished Professor in the School of Medicine Rana Gupta, PhD Rana Gupta, PhD

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And here's a very cool new paper from my UAB colleague Glenn Rowe (this is Matt speaking) which PGC1alpha/beta and PRC (triple KO!) were all conditionally deleted in mouse skeletal muscle demonstrating its essential role for maintaining the mitochondria: tinyurl.com/9rjwkaam
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Spiegelman Lab retweeted
sofia ahola (@sahola6) profile picture
sofia ahola@sahola67 Mar 2023
Very happy how this cover art project turned out! The image shows extracellular, secreted proteins in the muscle that can be isolated for proteomics analysis as shown by Mittenbühler et al. @Melli_Mittenblr @LabSpiegelman @Cell_Metabolism cell.com/cell-metabolism/ful…
Image from sofia ahola (@sahola6)
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A wonderful reunion of Stan Korsmeyer postdocs and SJK Professor @LabSpiegelman at the Gordon Conference on Mitochondria in Health and Disease. Stan’s amazing legacy of master mentorship, intellectual generosity, scientific rigor & commitment to cancer cures lives on. @DanaFarber
Image from Loren Walensky (@LorenWalensky)
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Our 20th Anniversary Symposium may be viewed virtually Thursday November 3: specialevents.ucsf.edu/event… Come listen to our speakers @LabSpiegelman @lbeutler7 @annagloyn @drdeancommxn @MAndersonUCSF @JulieBSneddon @LowensteinMD @kickassscience1 @MValdearcos and many more!
Image from Diabetes Center at UCSF (@AtUcsf)
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📢 Our recent Stanley Fahn Awardee Dr. Tae-In Kam @HopkinsMedicine has a @PNASNews fresh out of the press, where he shows that irisin, a small, exercised-induced polypeptide secreted by skeletal muscle, prevents the accumulation of pathologic alpha-synuclein #Parkinsonsdisease
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Spiegelman Lab retweeted
NEJM (@NEJM) profile picture
NEJM
@NEJM24 Jun 2022
The just-announced U.S. Supreme Court decision in Dobbs v. Jackson Women’s Health Organization represents a stunning reversal of precedent that inserts government into the personal lives and health care of Americans. nej.md/3Aa5cKe
Image from NEJM (@NEJM)
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We were please to be featured in this new @MGHBrainHealth video about our research on Irisin! Tune in to hear Dr. Wrann explain how Irisin plays a role on #cognitivefunction to learn more! youtube.com/watch?v=uoLWDQBG…
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Wrann Lab has joined twitter! Follow to learn more about how exercise affects the brain and metabolism! ! Our goal is to combat neurodegenerative diseases and to share our knowledge. #neuroscience #education #science #Harvard #medicine #fitness #exercise #BrainMatters
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New paper from our lab in @nchembio on how nucleotides signal to peroxisomes to modulate synthesis of ether lipids that promote mitochondrial respirasome assembly and cell growth. Great team work @puigserver_lab @GygiLab @DanaFarber @HarvardCellBio nature.com/articles/s41589-0…
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