
Assistant Prof @YalePathology, @YaleMed | Member @YaleAge | Former @HarvardMed | Inflammation, metabolism, aging
New Haven, CT
Joined April 2012
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New opportunity:
I am organizing a Topical Collection with @JoVEJournal on “An Integrated Toolbox to Study Skeletal Muscle Immunobiology in Exercise, Injury, and Aging.”
Interested in contributing?
Please submit an abstract here: jove.com/methods-collections…
P. Kent Langston retweeted
Now online! Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages dlvr.it/TW3Xtk
P. Kent Langston retweeted
Now online! The pyrin inflammasome senses OCTN2-mediated uptake of extracellular ʟ-carnitine from muscle injury or ingestion dlvr.it/TW1kKk
P. Kent Langston retweeted
A new study from @VishwaDeepDixi1, PhD, DVM, Director of the Yale Center for Research on Aging & Professor of Pathology @YaleMed, reveals that ammino acid can diminish age-related inflammation. #aging #inflammation shorturl.at/nqC3f
We are so happy & honored to be part of the @YaleAge @yalepathology community. Thank you for your support! Video on LangstonLab.org
Kent Langston, PhD, asst. prof. of pathology @YaleMed, discusses work being done in @Langston_Lab to demystify the role of the immune system in the regulation of skeletal muscle functions w/an ultimate goal of uncovering novel cellular & molecular targets that can be modulated to preserve or improve muscle health in the face of aging & disease. @YaleAge bit.ly/4ifL9ij
P. Kent Langston retweeted
We seek to fill a tenure-track faculty position at the Assistant or Associate Professor Level (PhD or MD/DVM/PhD) to build an interdisciplinary research program here at @YaleAge, part of @YalePathology & @YaleMed. #pathologyjobs Learn more & apply here: apply.interfolio.com/186720
P. Kent Langston retweeted
We seek to fill a tenure-track faculty position at the Assistant or Associate Professor Level (PhD or MD/DVM/PhD) to build an interdisciplinary research program here at @YaleAge, part of @YalePathology & @YaleMed. #pathologyjobs Learn more & apply here: apply.interfolio.com/186720
P. Kent Langston retweeted
We seek to fill a tenure-track faculty position at the Assistant or Associate Professor Level (PhD or MD/DVM/PhD) to build an interdisciplinary research program here at @YaleAge, part of @YalePathology & @YaleMed. #pathologyjobs Learn more & apply here: apply.interfolio.com/186720
P. Kent Langston retweeted
We seek to fill a tenure-track faculty position at the Assistant or Associate Professor Level (PhD or MD/DVM/PhD) to build an interdisciplinary research program here at @YaleAge, part of @YalePathology & @YaleMed. #pathologyjobs Learn more & apply here: apply.interfolio.com/186720
I will be presenting in the Session 7 at #IBEC2026 as well as Course 3 in the post-conference meeting. Hope to see you there! -Kent
P. Kent Langston retweeted
Online now!✨Mining the longitudinal plasma proteome of CALERIE participants, @MishraManish29, @Hee_Hoon_Kim et al link C3a to inflammaging. In aged mice, visceral fat macrophages produce C3a and neutralizing it blocks inflammaging @VishwaDeepDixi1 nature.com/articles/s43587-0…
P. Kent Langston retweeted
1st author paper in Nature Aging🥳
Unbiased CALERIE participants' exoproteome analysis and a reverse translational study found inhibition of C3a, a complement component, is an inflammaging checkpoint. 1/
Kudos to @MishraManish29 @VishwaDeepDixi1 and team!
nature.com/articles/s43587-0…
P. Kent Langston retweeted
When we discovered irisin in 2012 (Bostrom et al), we described its actions in terms of the browning of the white fat and anti-diabetic effects. Here, in collaboration with the Mathis lab, we re-examine this in mechanistic detail. nature.com/articles/s42255-0…
New job posting: Interested in immunology, exercise, and aging? The Langston Lab is recruiting a highly motivated postdoc with a strong background in immunobiology and/or biomedical engineering.
Join our growing team @YaleMed @yalepathology @YaleAge
postdocs.yale.edu/posts/2026…
P. Kent Langston retweeted
Caloric restriction in humans reveals immunometabolic regulators of health span | Science science.org/doi/10.1126/scie…
Effects on thymus rejuvenation in humans (functional thymic vol and TRECs) were one of the unexpected finding from NIA funded CALERIE trial.
P. Kent Langston retweeted
In the @Langston_Lab at @YaleMed, researchers work to understand how cells in tissues sense exercise & how exercise impacts inflammation w/the goal of unlocking therapies for chronic disease & age-related frailty. bit.ly/4burGab
New in @NatImmunol: we uncover mechanosensing by Piezo1 on mesenchymal stromal cells as a fundamental mechanism of stress-induced immunomodulation in skeletal muscle, particularly in contexts of acute exercise and injury.
nature.com/articles/s41590-0…
This study builds on our prior work in @SciImmunology demonstrating that muscle inflammation is not merely a feature of the stress response to exercise but a regulator of exercise adaptation science.org/doi/10.1126/scii…
We continue to explore how non-parenchymal cells regulate muscle function, exercise benefits & age-related decline in the Langston Lab!
@YaleMed @YalePathology @YaleAge
We are recruiting a postdoc – please reach out if interested.

















