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Backing entrepreneurs using Deep Tech to solve trillion-dollar problems

San Francisco
Joined February 2012
A look at what @DCVC /@DCVCBio founders delivered /this week/: 💪 🚚 🤖 Fleet-scale humanoid deployment: @agilityrobotics expanded its commercial footprint with GXO Logistics, soon moving into facilities across North Carolina and Tennessee after crossing an unprecedented 100,000-tote operational milestone. ⚛️ Microreactor regulatory progress: @RadiantNuclear cleared a major hurdle as the US Dep't of @ENERGY approved the documented safety analysis for its Kaleidos test unit at @INL, moving it one step closer to criticality. 🧬 Predictive computational biology: Latus Bio published the first predictive computational model of Huntington’s disease built on human data in Nature Communications, along with preclinical data supporting its gene therapy candidate LTS-201 as a potentially disease-modifying treatment. This is BIG. 🔬 Rapid stem cell reprogramming: @SyntaxBio drew major biotech coverage for using its CRISPR-based Cellgorithm platform to differentiate human stem cells into pancreatic beta cells in just four days, an early step toward faster development of cell therapies for Type 1 diabetes. 🎯 Clinical precision oncology: @FrontierMeds posted a standout 56% confirmed response rate in its Phase 1 lung cancer trial (FMC-376) presented at the ESMO - European Society for Medical Oncology Congress. 💡 Quantum photonics breakthrough: @NVisionQuantum published research introducing the first organic molecule capable of directly linking quantum processors with light, unlocking a scalable path for optical quantum networking. 🧠 Frontier AI compute architecture: Unconventional AI (@unconvAI) AI CEO @NaveenGRao joined @20vcFund to talk about why inference could be a $10 trillion market and why robotics could be 100x bigger than coding agents. Onward!
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A look at what @DCVC founders delivered /this week/: 💪 🚚 ⚛️ Defense-grade nuclear momentum: @RadiantNuclear was selected by the @USNavy to supply its microreactor for Naval Weapons Station Crane while advancing site planning with the @USArmy to install three microreactors at Fort Benning. 🤖 Factory-floor humanoid deployment: @agilityrobotics signed a commercial agreement with @AGCOcorp, a farm equipment leader, to deploy Digit humanoids in its Kansas manufacturing facilities—after partnering just last week with @nyobolt for ultra-fast charging batteries to unlock near-continuous uptime. 💧 Industrial water circularity at scale: @zwitterco secured a strategic investment from water and hygiene giant @Ecolab to scale its zwitterionic membrane filtration systems across food and beverage processing plants. 🧬 Multimodal AI data infrastructure: BioStack raised a $9.5M Series Seed (joined by DCVC) to expand its cross-border clinical data platform across 100M+ de-identified patient records for medical AI models. ⚡ Geothermal grid leadership: @fervoenergy's Cape Station in Utah was spotlighted by @Reuters as the first greenfield enhanced geothermal plant in the world to hit commercial operation. ✨ A glass half-full: @Forbes named @DCVC co-founder @mattocko to its list of the Greatest Living American Optimists, for backing science- and computer-intensive deep tech founders solving the world's hardest problems. Deep tech is grueling. It's also inspiring. Onward!
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(1/7) A look at what @DCVC founders delivered this week 💪🧵👇 ⚡ A landmark grid-power deal: @MainspringEnrgy signed a supply agreement with @AEPnews for up to 1.6 GW of linear generators in a deal that could top $4 billion.
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LLMs optimize for what humans like to read, not what machines need to do. The next leap in AI won't come from larger models, but from architectures that make intelligence cheaper and more machine-native (cue @DCVC-backed @typesafeai). Explore Opportunity 1.3: dcvc.com/reports/deep-tech-o… #DCVCDeepTech
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The microbiome is essential to human health but until recently, we couldn't do much with it. @DCVC's @jason_pontin examines the breakthroughs finally making the microbiome druggable (DCVC-backed @kanvasbio leads here). More in the Deep Tech Opportunities report: dcvc.com/reports/deep-tech-o… #DCVCDeepTech
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A look at what @DCVC founders delivered /this week/: 💪 🚚 🧠 Major funding for machine-native AI: @typesafeai closed an $870M Series A led by @a16z at a $7.5B valuation—with DCVC participating alongside @sequoia —less than a month after emerging from stealth with a $40M Series Seed led by DCVC at a ~$200M valuation. 1/3 of the @FortuneMagazine 500 have already adopted their first model, Jev. ⚛️ Record-setting UK quantum milestone: @universalquant raised over $100M in Series A funding co-led by DCVC—the largest-ever Series A for a UK quantum firm—to scale its modular trapped-ion architecture into error-corrected quantum computers. 🏛️ @DARPA validated quantum scale: @Atom_Computing and @IonQ_Inc advanced to the final stage (Stage C) of DARPA’s Quantum Benchmarking Initiative—with both companies unlocking agreements worth up to $300M each in potential funding to build utility-scale quantum systems. 🌾 Award-winning AI agriculture: @verdantrobotics was named to @FastCompany's list of the Next Big Things in Food and Agriculture for its SharpShooter AI tech, which cuts pesticide application by up to 99%. 🛸 In-space operations & defense: @GoToImpulse (Impulse Space) reached the finals for the @SpaceNews_Inc Icon Awards after demonstrating autonomous proximity operations between two Mira spacecraft in LEO, while @FortemTech showcased its autonomous counter-drone radar integrated directly onto new unmanned ground platforms. ⚡ Grid flexibility & geothermal momentum: @EmeraldAi_'s flexible load coalition with @Google and @nvidia made @Reuters as a blueprinted fix for data center power bottlenecks, while @fervoenergy's record-breaking Cape Station launch continued making headlines across national energy press. Onward!
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Nuclear microreactors are ready to bring firm power to locations the grid cannot. In the 2026 Deep Tech Opportunities report, @DCVC General Partner Dr. @RachelSlaybaugh breaks down how and why now: dcvc.com/reports/deep-tech-o… #DCVCDeepTech
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With few exceptions, the massive factory floor is no longer a path to cost-competitive production. @DCVC GP @milo_werner explains how & why industrial production will become more modular, more programmable, and cheaper in the 2026 Deep Tech Opportunities report: dcvc.com/reports/deep-tech-o… #DCVCDeepTech
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(1/2) Climate Week NYC is off to the races! A few @DCVC highlights below. Follow along for more! #ClimateWeekNYC
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💧 Disposing of Permian Basin wastewater is becoming too expensive and environmentally hazardous. Deep tech is turning that liability into a resource. Read the investment case in our Deep Tech Opportunities report: dcvc.com/uploads/Reports/DTO… #DCVCDeepTech
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