@Dorie00
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Lead Scientist @HelmholtzMunich | Metabolism | Cancer Cachexia | Transcriptional regulation | Tissue clearing l Light-sheet imaging
Joined August 2010
- Tweets484
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Incredibly happy to see our work published in @Nature today
🥹
By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution
nature.com/articles/s41586-0…
Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell.
In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉
nature.com/articles/s41586-0… led by @Dorie00 & @yingchen733
Doris Kaltenecker retweeted
The cardiovascular benefit from Ozempic in the large randomized trial was substantially not related to weight loss
academic.oup.com/eurheartj/a…
Doris Kaltenecker retweeted
We found an adrenergic iron–MSRA axis that regulates methionine redox signaling and adipose browning. Disrupting MSRA preserved tissue mass and prolonged survival in tumor-bearing mice. Huge congrats to Jung Seung Nam, who led this work! nature.com/articles/s43018-0…
💫 Thrilled to share that I’ll join @IMPvienna as a Group Leader in March 2027! My lab will study systemic disease across biological scales, from molecular mechanisms to organism-wide dynamics, with a focus on cancer cachexia.
👉🏻 imp.ac.at/groups/doris-kalte…
She’s coming to the IMP, and she’s recruiting! 🔬 Doris Kaltenecker will join the IMP as a Group Leader in March 2027. Her lab will study organ-to-organ communication in systemic diseases, with a focus on cancer cachexia: imp.ac.at/news/article/doris…
🎓 I’ll be recruiting PhD students through the Vienna BioCenter Autumn 2026 PhD call. If you’re interested in inter-organ communication, whole-body imaging or systemic disease biology, get in touch! training.vbc.ac.at/phd-progr…
Doris Kaltenecker retweeted
She’s coming to the IMP, and she’s recruiting! 🔬 Doris Kaltenecker will join the IMP as a Group Leader in March 2027. Her lab will study organ-to-organ communication in systemic diseases, with a focus on cancer cachexia: imp.ac.at/news/article/doris…
Doris Kaltenecker retweeted
In 2025, one child got a CRISPR therapy made for him. Gene therapy's "moon landing". My #ERCStG ONE2MANY asks how editing scales from n=1 to many, in the heart: one edit for a group of mutations, AI-guided protein engineering & delivery. Thanks @ERC_Research & my fantastic team!
Doris Kaltenecker retweeted
Now online in @CD_AACR: Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia - by @JulianoMacha17, Stephan Herzig, @BerrielDiaz and colleagues @HelmholtzMunich @helmholtz_diabc
Now online: Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia doi.org/10.1158/2159-8290.CD…
Doris Kaltenecker retweeted
This newly published work in @NatureComms has been a long time coming! Huge collaborative effort with @A_bonetto_PhD and countless others, scratching the surface of the liver’s role in driving cancer-associated musculoskeletal wasting. nature.com/articles/s41467-0…
🔥 Check out our new study in Cancer Discovery @CD_AACR! We identify tumor-secreted ADAMTSL4 as a driver of cancer cachexia through local TGF-β1 activation.
Congratulations to @JulianoMacha17 and the team! Happy to have contributed!
aacrjournals.org/cancerdisco…
Doris Kaltenecker retweeted
Multi-organ proteomic atlas of obesity regression in male mice dlvr.it/TV6Q9Y
Doris Kaltenecker retweeted
We are opening the call for the first generation of Founding Principal Investigators of the Cori Institute in Graz.
We are looking for scientists who want to understand metabolism as the fundamental organising logic of life.
🤖 Made with AI
Doris Kaltenecker retweeted
Got your own 3D data from clearing and light sheet imaging, but no idea how to tackle the analysis? We have just the solution for you in Munich: A two-day course on deep learning and VR-assisted segmentation, atlas registration, and so on! Take the course @erturklab
Doris Kaltenecker retweeted
Plasma proteins can predict metabolic liver disease (MASLD) up to 16 years ahead of its clinical appearance.
One study after another showing the forecasting value of proteomics
nature.com/articles/s43587-0…
Doris Kaltenecker retweeted
SARS-CoV-2 spike protein accumulates & persists in the body for years👇🏻.
We’re developing advanced imaging & AI to cure Long COVID & beyond👇🏻.
Join us 🤗
nature.com/articles/s41586-0…
cell.com/cell-host-microbe/f…
biorxiv.org/content/10.64898…
biorxiv.org/content/10.64898…
biorxiv.org/content/10.1101/…
Doris Kaltenecker retweeted
📰 New Feature in @NaturePortfolio on #CancerCachexia
The article explores recent advances in cachexia research, including work by @BerrielDiaz (IDC) on organ crosstalk and the role of liver-derived signals in metabolic regulation.
➡️ nature.com/articles/d41586-0…
Doris Kaltenecker retweeted
💫 I'm excited to share our new Comment @NatureRevEndo, calling to reframe #cancercachexia from malnutrition to treatable metabolic disease: nature.com/articles/s41574-0…
Doris Kaltenecker retweeted
Excited to share our new paper in @ScienceMagazine A subset of lung cancers drives cachexia, not through factors circulating in the blood, but through local lung sensory neurons. science.org/doi/10.1126/scie… big thanks to first authors Michael and @s_kotschi our collaborators
What if one of cancer’s most devastating side effects could be reversed?
Cancer cachexia is a debilitating wasting syndrome that affects many people with cancer, yet treatment options remain limited.
Team CANCAN has published new research in @ScienceMagazine that highlights a previously underappreciated driver of cancer cachexia: localised signals from tumours acting directly on sensory neurons.
This is a big step toward reframing cancer cachexia as not only a systemic metabolic condition, but also one shaped by tumour–nerve communication.
🎥 @ThalesPapaG, Co-Investigator on team CANCAN and team InteroCANCEption, explains the discovery and what it could mean for patients.
Read the full paper: science.org/doi/10.1126/scie…
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Team CANCAN is funded by @CR_UK and @theNCI through Cancer Grand Challenges.
Doris Kaltenecker retweeted
This study changed the way I think about cachexia. For a long time we have been looking for tumor-secreted factors that induce sickness and wasting. @ThalesPapaG now shows us that the "sickness signal" can be transmitted directly to the brain via sensory neurons. Congrats to the whole team. #CANCAN @CancerGrand @theNCI @CRUKresearch
science.org/doi/10.1126/scie…
Doris Kaltenecker retweeted
1/5
Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
biorxiv.org/content/10.64898…
Doris Kaltenecker retweeted
Our recent work in @Nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage.
Proud to see >75K accesses & >60 news stories in the first week.
nature.com/articles/s41586-0…
next come>biorxiv.org/content/10.64898…