Our data, beautifully reimagined by @TeamSciStories for the November cover of @NatImmunol @aliciaguilar_ @gibran_edun
nature.com/ni/volumes/27/iss…
Anastasia Tikhonova retweeted
Can we interrupt the inflammatory signals driving clonal hematopoiesis? Our new study, led by @jaynathemistry, identifies neutrophil-derived S100A8/A9 as a potential therapeutic target to limit DNMT3A-mutant stem cell expansion. @Haematologica
doi.org/10.3324/haematol.202…
Anastasia Tikhonova retweeted
We've had two thrilling days in Dallas gathering the scientific community for Advancing Immunotherapy for Osteosarcoma, organized with @OSInstitute. The challenges are immense, but so is the potential. Together, we're working toward better treatments for patients who urgently need them.
Anastasia Tikhonova retweeted
Excited to share our new preprint! ChromE-seq reads 3D chromatin and gene expression in one cell. Across ~400,000 human primary cells, B lineage has the fewest chromatin loops and is most perturbed in trisomy 21, driving the B-cell block in Down syndrome.
biorxiv.org/content/10.64898…
I remember Dan from my days as a postbac at the NIAMS. Such a wonderful person and scientist. So incredibly sad to hear of his passing. A tremendous loss for the immunology community. cell.com/immunity/fulltext/S…
Anastasia Tikhonova retweeted
So proud of Karl!! ♥️. Stanford University professor Karl Deisseroth wins 2026 Nobel Prize in physiology or medicine med.stanford.edu/news/all-ne…
Anastasia Tikhonova retweeted
Karl Deisseroth, Peter Hegemann and Georg Nagel win the 2026 Nobel Prize in Physiology or Medicine for their work on optogenetics, which has revolutionized neuroscience
go.nature.com/4zk3Rfz
Anastasia Tikhonova retweeted
🧬 Happy to share our new study in @BloodAdvances! Many inherited cancer predisposition genes only cause disease once a second mutation arrives. We tested that directly, combining CRISPR editing of human primary blood stem cells with xenotransplantation.🧵doi.org/10.1182/bloodadvance…
Anastasia Tikhonova retweeted
A new study from MSK and collaborators (@jonasschluter and @DrMvandenBrink) suggests that consuming high levels of sugar while taking antibiotics may worsen gastrointestinal side effects in patients receiving bone marrow transplants.
The study, co-led by Dr. Jonathan “Tsoni” Peled (@tsonipeled) and published in @Nature, tracked the diets and gut microbiomes of 173 hospitalized transplant patients. The data showed that high-sugar foods and antibiotics appeared to compound damage to the microbiome.
Learn more about what these findings could mean for nutrition during cancer treatment: bit.ly/4AH2wRc
Tissue-trained immunity is all the rage. Congratulations @PayalYokota and @Kamal_M_Khanna 🎉
Thrilled to share this labor of love, #freshoffthepress in @Nature about how Type 2 immune history trains lung macrophages for viral disease tolerance.👇
nature.com/articles/s41586-0…
This was impossible without my mentor @Kamal_M_Khanna & our coauthors. 🧵 on 🦋payalyokota.bsky.social
Thank you @LeeGrimesLab for this elegant and thoughtful News & Views on our work. #StromalImmunity
nature.com/articles/s41590-0…
Anastasia Tikhonova retweeted
In people with age-related blood stem cell mutations, our study found early pre-fibrosis and inflammatory regions in the bone marrow, that may set the stage for blood cancer development.
The @NatImmunol study was led by @DrStass @UHN @pmcancercentre:
nature.com/articles/s41590-0…
Anastasia Tikhonova retweeted
🚨 Out today in @NatImmunol, a study from @PMResearch_UHN’s @DrStass identifies distinctive early changes in the bone marrow environment in people with age-related blood #StemCell mutations, before blood cancer develops.
⬇️
In people with age-related blood stem cell mutations, our study found early pre-fibrosis and inflammatory regions in the bone marrow, that may set the stage for blood cancer development.
The @NatImmunol study was led by @DrStass @UHN @pmcancercentre:
nature.com/articles/s41590-0…
What happens to the bone marrow niche in #CHIP? We find that CHIP is associated with fibro-inflammatory hubs emerging before the disease.
Co-led by our fantastic @aliciaguilar_ and @gibran_edun
nature.com/articles/s41590-0…
#ClonalHematopoiesis #PreTumorMicroenvironment #Hematopoiesis
Anastasia Tikhonova retweeted
Come work with us at CCHMC!
We’re recruiting tenure-track faculty in leukemia research @CincyChildrens . Join the Advanced Leukemia Therapies and Research Center - a collaborative community spanning discovery science, translational research, and clinical investigation.
jobs.cincinnatichildrens.org…
Anastasia Tikhonova retweeted
Very grateful for the support of @TheMarkFdn to pursue our biggest and boldest ideas!!
#BloodCancerAwarenessMonth #JAXresearch #JAXstemcellsdev
This #BloodCancerAwarenessMonth, we’re spotlighting 2023 Emerging Leader Award winner Jennifer Trowbridge (@TrowbridgeLab) of @JacksonLab. She’s looking for answers to a big question: why aging blood cells develop into cancer in some individuals but not others.
Anastasia Tikhonova retweeted
New research from @PMResearch_UHN shows how chemotherapy can cause long-term damage to bone & and blood-forming cells in the bone marrow by triggering inflammation—offering insight into why many cancer survivors face lasting health challenges.
🔗: uhnresearch.ca/news/9-18-202…
ALT Chemotherapy patients receiving IV treatment in a hospital infusion clinic.
Anastasia Tikhonova retweeted
2/ First author: Ximing Li
Senior author: Dr. Anastasia Tikhonova (@DrStass)
Featured on the cover of @BloodPortfolio: ashpublications.org/blood/ar…
Anastasia Tikhonova retweeted
Excited to share our review with Jessica S. Ross, Esther Redin Resano, and @charlesrudin in @TheLancet on the changing therapeutic landscape in small cell lung cancer sciencedirect.com/science/ar…
Three-dimensional quantitative tissue clearing reveals differences in osteovascular niche of aged and young human mesenchymal stromal cells | Nature Biomedical Engineering nature.com/articles/s41551-0…
