lab of Prof. Eunyong Park at @berkeleymcb @QB3Berkeley using biochemistry&cryo-EM to study mechanisms of protein transport and quality control pathways
Berkeley, CA
Joined August 2022
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Check out our preprint on the Doa10 E3 ligase, the key player in ERAD-C. We combined cryo-EM, MD simulations (another cool collaboration with JC Gumbart and Diane Lynch!), and biochemical approaches to reveal how Doa10 recognizes its substrate proteins. biorxiv.org/cgi/content/shor…
Updates: This is now published in Nature Communications. nature.com/articles/s41467-0… In revision, we tested a few more substrates, including TA proteins. All seems to interact directly with the "lateral tunnel" we identified.
Our story about the mitochondrial TIM23 complex is finally out @Nature rdcu.be/de4jn after >1.5yr revision. Great, forceful teamwork between Sue Sim and Yuanyuan Chen and fantastic collaboration with JC Gumbart's group.
Combining cryo-EM, mutational analysis, in-vivo photocrosslinking, and MD simulations, we show mitochondrial protein import across the inner membrane is mediated by the cavity formed by the Tim17 subunit, not by Tim23 as previously thought.
Park Lab at UC Berkeley retweeted
@nature, researchers present cryo-EM and related data to show the mechanism that by which the TIM23 complex mediates protein import into mitochondria is not quite as was previously thought.
nature.com/articles/s41586-0…
Park Lab at UC Berkeley retweeted
The #ShawPrize in #LifeScienceAndMedicine 2023 is awarded in equal shares to Patrick Cramer and Eva Nogales for pioneering structural biology that enabled visualization, at the level of individual atoms, of the protein machines responsible for #genetranscription.
#ShawPrize2023
Our paper on high-res structures of inhibitor-bound Sec61 is now published in @nchembio rdcu.be/dbVeo. Big congrats to Sam, Laurie, and Tina , and many thanks to other coauthors, especially Martin Spiess, Dominic Hoepfner, Wei Shi, Craig Forsyth, and @Blanchard_Lab
Highlight in Nature Reviews Drug Discovery: Inhibiting Sec61-mediated protein translocation nature.com/articles/d41573-0…
Park Lab at UC Berkeley retweeted
Our work on the S1P transporter Spns2 is online @CellCellPress. The work was led by @shah_med @HongtuZhao, and a wonderful collaboration with @XiaochunLi2. We revealed the transport and inhibition mechanisms of this important sphingolipid transporter.
authors.elsevier.com/c/1h7hY…
Park Lab at UC Berkeley retweeted
A new paper from @EParklab determined high-resolution structures of the human Sec61 channel inhibited by several structurally distinct small molecules and revealed the common inhibitor binding site. rdcu.be/dbVeo
Park Lab at UC Berkeley retweeted
science.org/doi/10.1126/scie…
Excited to share our new work out today in @ScienceMagazine, led by stellar postdoc Regina @hijaishin!
We report the discovery of LYCHOS, a candidate cholesterol sensor for the mTORC1 kinase. Below is a brief summary of the story.
Our lab's first tweet! We are very excited to share our new preprint on the mechanism of Sec61 translocon inhibition by small molecules (7 distinct compounds). We thank our collaborators!
A common mechanism of Sec61 translocon inhibition by small molecules biorxiv.org/content/10.1101/…
