Currently postdoc in @BriggsGroup @MPI_Biochem | PhD @ScheuringLab @WeillCornell | structural biology, biophysics, cryo-tomography, atomic force microscopy
Munich, Germany
Joined February 2017
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This is a short video description of our recent work.
Elastically loaded clathrin lattices relax to increased curvature after AFM nanodissection.
@ScheuringLab @ScienceAdvances
advances.sciencemag.org/cont…
Grigory Tagiltsev retweeted
This is a molecular dynamics visualization of TGF-β receptor 1, created in @Blender using #MolecularNodes. TGF-β pathway regulates many cellular processes including cancer formation. 1+ month of dedicated work from system prep to final render. #sciart #b3d #md #cancerdrugs
Grigory Tagiltsev retweeted
Check out our new paper in @NatureComms!
We report a much improved structure of the TRPV3 pentamer, analyzing its high permeability capabilities and its mechanistic ability to reversibly transition to and from the canonical tetrameric state.
@ScheuringLab
nature.com/articles/s41467-0…
Grigory Tagiltsev retweeted
Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors
Now, an exciting collaboration between our labs @ColumbiaBiochem reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online @CellCellPress!
sciencedirect.com/science/ar…
Grigory Tagiltsev retweeted
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @MargotRiggi :
Was excited to determine the in situ clathrin structure for this project! That’s my first EM-structure upload to EMDB. Can I tell my mom I am a structural biologist now? 😄 #cryoET
We performed subtomogram averaging on complexes from >3 MDa to ~200 kDa, including 80S ribosomes, Rubisco, clathrin, microtubules, ATP synthase photosystem II, and nucleosomes. Most density maps achieved sub-nanometer resolution!🔬✨ #CryoET #StructuralBiology #VisualProteomics
Finally out!!! 🎉🎉🎉
Excited to share our new preprint and 1800+ tomograms with the community! 🎉 This is our first step towards building a visual proteomics dataset for Chlamydomonas reinhardtii. I hope the community will be able to make good use of this data!🔬#CryoET
biorxiv.org/content/10.1101/…
Grigory Tagiltsev retweeted
Thrilled to announce that in January I will be opening my own lab at the Friedrich Miescher Laboratory/@MPI_Bio of the Max Planck Society @maxplanckpress in lovely Tübingen, Germany!
New preprint from my awesome labmates! It was really cool to watch from the front seat how this story unfolds! Congrats James Stacey, @F4ustus, @BriggsGroup and co-authors! 🤩
Our new preprint is out: we solved the structures of HIV-1 matrix (MA) from intact virions by SPA. The structure led us to a surprising discovery resolving a long mystery in HIV-1 biology – peptide SP2 regulates the maturation of the HIV-1 matrix. 🧵1/x
tinyurl.com/c7szhtfa
Grigory Tagiltsev retweeted
🎉 NanoLocz is Celebrating Its 1st Birthday! 🎉
To mark this milestone, we’re hosting some User Meetings for new and experienced users (all are welcome). An open session to share tips, feedback, ask questions, or simply observe to see if it can help your own #AFM analysis.
Grigory Tagiltsev retweeted
We are looking for a #PhD student to study #MolecularMachines driving #membranetrafficking by #cryoEM #cryoET #temtomo. Image processing fans are particluarly welcome.
Grigory Tagiltsev retweeted
Using #Ftractin to visualize #actin in living cells?
We determined the F-tractin-F-actin structure and showed that the probe is nearly identical to #Lifeact. Check out light microscopy by Athul Sivan @RolandSoldner and #cryoEM by @DmitryShatskiy and me biorxiv.org/content/10.1101/…
Grigory Tagiltsev retweeted
Happy to share that our preprint on the regulation of NPC (a)symmetry is online! #teamtomo #NPC #phdlife
Wouldn't have been possible without the support of the amazing @Beck_Laboratory and great collaborators outside @svenklumpe, @MandyBoermel, @WilflingFlorian!
Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, @JennySachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵
Grigory Tagiltsev retweeted
Sharing our latest paper! Congrats to @thon_oli, @iHeart_proteins and Zhihan Wang for their amazing work! PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK disq.us/t/4qr57vg
@WCMAnesthesia, @WeillCornell, @MBiophys_WCMSKI
Grigory Tagiltsev retweeted
Congrats to @biozentrum @snsf_ch Ambizione Group Leader @FlorentWaltz on this stunning study🤩 of respirasome structure & organization inside native cells! It's amazing how quickly in situ #cryoET is advancing. Read Florent's thread🧵 for the high-resolution details🔎🦠 #TeamTomo
Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳
Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!
biorxiv.org/content/10.1101/…
😍😍😍
Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳
Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!
biorxiv.org/content/10.1101/…
Grigory Tagiltsev retweeted
PostDoc Position Now Open!
🎞 Join our High-Speed AFM team in Leeds
Application Deadline: 1st September 2024
Apply Online Here: jobs.leeds.ac.uk/EPSPA1117
Wow!! Congrats!!!
I have just opened my lab at the Weizmann Institute of Science, Department of Chemical and Structural Biology, and am looking for students!
Please share! :)
For more details, check out my website: weizmann.ac.il/CSB/lansky
Grigory Tagiltsev retweeted
Our mini-review of the recent reports revealing the architecture of the Commander complex is online.
s.gwdg.de/s6BN9g
Grigory Tagiltsev retweeted
Excited to share our recent study Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1 published this week @Nature led by amazing @Yeeun_Jecy_Son in collaboration with @TimCKenny @ArtemAKhan @KivancBirsoy
@MSKCancerCenter
nature.com/articles/s41586-0…
Grigory Tagiltsev retweeted
Congratulations to Dr. Timothy Ryan on being elected to the National Academy of Sciences (@theNASciences), one of the highest honors a scientist can receive.
Dr. Ryan of @WCMAnesthesia is among 120 scientists in the U.S. named to the academy this year.
bit.ly/3QsZFpw
