Evolutionary Virologist/Immunologist, Asst. Professor @UTSWimmuno
Dallas, TX
Joined February 2016
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Our New: Going places -- us with Steve Baker @sfbkr.bsky.social (now @LoyolaStritch)
...how trafficking to and from #mitochondria can shape infection outcomes as part of @JVirology New Voices in Virology journals.asm.org/doi/10.1128…
sfbkrlab.org/ @UTSWMedCenter @utswnews
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Our newest: Antiviral & inflammatory proteome is regulated by a logic timer imparted by #mitochondria activity...what if mitos. were not co-opted for "energy" but host defense?...implications for non-infectious diseases biorxiv.org/content/10.64898… @biorxivpreprint #viruses #evolution
The plot thickens...our thoughts on #mitochondria and metabolism during infection. TL;DR, Maybe sensing of mito. dysfunction evolved as an important signal to cue progression of immune states. @ASMicrobiology @mbiojournal
journals.asm.org/doi/10.1128…
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Divide and conquer: antiviral restriction of #influenza A virus
by a novel ISG15 spliceform by @sfbkr.bsky.social and Co..the plot thickens #genesInPieces
biorxiv.org/content/10.64898… @biorxivpreprint @biorxiv_micrbio
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Switches: New..lots of protein-coding mRNAs encode #miRNA ..former Ph.D. student's last hurrah building on our #mitochondria C15orf48/miR-147b stuff bmcgenomics.biomedcentral.co…
Lab first, #cookies, to kick off the new academic year…stay tuned #mitochondria
shine bright: sweet new set of gfp flu reporter viruses from @BakerLabLBRI biorxiv.org/content/10.1101/…
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Newest: Virologs mark #RNA metabolism as an evolutionary battleground during infection - Collaboration w/Chris Sullivan & Kayla Szymanik @PLOSPathogens journals.plos.org/plospathog…
Our newest out: Shifting gears - after great #mitochondria mtg in Spain #CSMito2024 @CellSymposia - just like we found with metabolism & antiviral responses; cheers to @PLOSPathogens for investing in our work #utswmed journals.plos.org/plospathog…
Our newest: My grad students & their "sweet" project ..."In principle, such cellular circuitry could rapidly adapt immune responses by sensing changing metabolite levels consumed during viral replication and cell proliferation." biorxiv.org/content/10.1101/… #mitochondria #virologs
Less is more sings the songbird: extensive loss of inflammasome components incl. ASC in birds. NLRP3 & CARD8 survive the purge. Great collab. with Ed Miao @TheMiaoLab and Zach Billman @DukeU @DukeMGM @UTSWMedCenter @GenomeBiolEvol academic.oup.com/gbe/article…
#mitochondria on the front lines: Congrats to my dept. mate @ZhenyuZhonglab on his aspire early career award #AAI2024 @UTSWMedCenter @UTSWScience @utswimmuno - till Hawaii!
Instilling FEAR into viruses: a modified form of FACT triggers an ancient, broad acting antiviral response mediated by ETS1 - @GammonLab @NatureMicrobiol @UTSWNews tinyurl.com/y6a8bdcn
TEs in pieces: Cheers to my former baymate @edchuong on his new investigator award @CytokineSociety #cytokines2023 #strangerGenes
Maybe time is on our side in viral infection…Congrats to one of our rockstar immunology students @ImmYouKnowledgy in @jkpfeiff lab for their junior investigator award @CytokineSociety #cytokines2023 @UTSWNews #clock
Maybe you can cheat death...(or at least use it to break free) - 🍻 to @wang_guoxun an exceptional postdoc w/an exceptional eye & @TiffanyReeseLab -
a cool story to be part of along w/@OrchardLab_Rob #mitochondria #mimics #ohmy @utswimmuno @utswnews nature.com/articles/s41586-0…
Two unpublished stories from my stellar postdocs this afternoon #ASV2022 HALL OF IDEAS HI
Poxviruses, genomes, battlegrounds #goBig
W13-5 Pinkham 230PM
Me, mitos, and viruses #mitochondria #commandCentral
W13-7 Chappidi 300PM
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So many little proteins with unknown function 😱 - so happy in person meetings are back #ksmicropeptides22 #microproteins
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