The Orchard lab at UTSW! Host-pathogen interactions using functional genomics, mouse models, and whatever it takes.
Joined June 2018
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Check out this cool paper from @TiffanyReeseLab and @HancksLab ! Fun to see the story develop over time and glad to play a small part in it!
#viruses are the best cell biologists! We discover a new viral mimic of a host cell death protein required for #norovirus egress! @wang_guoxun @HancksLab @OrchardLab_Rob @utswimmuno @utswnews 🧵 1/
nature.com/articles/s41586-0…
Excited for the first paper from the lab published in @JVirology doi.org/10.1128/jvi.00707-22 Great team effort co-led by Linley Pierce in the Orchard lab and Meagan Sullender in @baldridge_lab.
A great dive into the history of an exciting project led by @SanghyunLeeLab. I unfortunately was on the losing side of that particular lunch bet. Article brings about great memories of my postdoc and reminds me how lucky I was to be surrounded by such talented scientists!
This Commentary is an invited article for 15th anniversary of @CellHostMicrobe. My honor to be a part of this celebration.
Many thanks to my dear colleagues @baldridge_lab @WilenLab @OrchardLab_Rob @AOmdphd for wonderful collaboration on norovirus work!
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Excited to share that our R35 MIRA grant from NIGMS to study new host-viral interfaces is officially funded! Thanks to everyone who helped make this happen.
We had a belated celebration for Mridula passing her qualifying exam earlier this year. New research area for the Orchard lab: finding the best donut shop in Dallas!
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It is important that mentors Do Nut🍩 forget about milestones accomplished during the pandemic. Today we have a late celebration of @BrittMStew passing her qualifying exam in 2020. Things may be crazy around us, but we are trying to have fun and do science while being safe 😷.
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Great mentor, awesome lab, fun science. Fantastic opportunity!
Recently defended or about to finish your PhD? We have postdoc positions available to study host antiviral immunity. From molecular mechanisms to in vivo pathogenesis to comparative evolutionary approaches, there’s something for everyone.
utsouthwestern.edu/labs/scho…
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Thanks @lbthackray and @AmerSocVirol for highlighting the amazing @BrittMStew from my lab. What a great idea to interview trainees ahead of ASV!
Meet Brittany Stewart @BrittMStew who studies phospholipids and noroviruses. She will give a talk (Program Number: W16-5; Flipping the Script: Phospholipid Distribution as a Mechanism for Host Defense). #LoveVirology
lmtv.podbean.com/e/lmtv-epis…
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Excited to have @kvnforsberg join UTSW. Awesome science and great opportunity for anyone interested in microbiology to join a rising star's lab!
I have exciting news!
This fall, I’ll be starting my lab in the Dept of Microbiology at UT-Southwestern (@UTSWNews) in Dallas. I’m thrilled to work alongside so many amazing colleagues and very grateful for the tremendous friends and mentors that who helped me along the way.
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Enjoyed this solid talk on viral entry and disassembly. Thanks @Dr_Sprggs !
Just had a master class in the cell biology of viral disassembly in our Microbiology Seminar Series from @Dr_Sprggs. Thanks for the awesome talk Chelsey!
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Excited to see this work published. Great job by @WilenLab and happy to play a small role in this story.
We havent forgotten our other favorite virus: #norovirus. We asked what cell types were murine norovirus infected. We deleted the CD300lf receptor from ~8 cell types. Tuft cells were essential for CR6 virus. @WilenLab @Yale_LabMed @YaleIBIO @VinnieViruses jvi.asm.org/content/early/20…
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Congrats to my friend Craig Wilen and his lab for their paper! Really impressive how much work and analysis went into this.
Excited to share our new paper out today: Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection cell.com/cell/fulltext/S0092… @CellCellPress @Yale_LabMed @YaleIBIO @YaleMed
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Congrats to Megan Baldridge @baldridge_lab and other bwf investigators!
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Really cool story showing a proviral function of IFIT2 by @MehleLab. Creative screen points to how a virus co-opts an antiviral protein.
nature.com/articles/s41564-0…
Couldn't say it any better! Come join us. Great community and a fun place to do science
If you're a senior postdoc in bacterial pathogenesis, apply to join us as an Asst. Professor in one of the most collaborative, supportive environments in academia. Tons of interaction, collaboration, support, grant writing workshops, brainstorming sessions, etc. Join our family.
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Really fascinating study that bridges Cryo-EM, biochemistry, and in vivo mouse models to show a new paradigm in viral entry.
So Excited - out today in Nature! Ubiquitination of envelope proteins in infectious virions Enhance Entry and Drive Tissue Tropism and Pathogenisis. Big congratulations and all credit to Dr. Maria Giraldo, Rajsbaumlab postdoc...
@ihii_utmb @UTMBProvost
nature.com/articles/s41586-0…
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Proud of @BrittMStew for giving a great talk today. Also, thankful for all the great talks that I can listen to during this pandemic!
I just presented my work "at" ASV for the first time and didn't die. People seemed to enjoy the talk. The real victory, though, is that my dog sat quietly during the entire talk and did not start howling until I was finished presenting. It's the little things.
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Glad to be a small part of this massive study led by @WilenLab and @JohnDoench. Really cool stuff has come out of this screening effort.
Thrilled to reveal our pre-print “Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection” Massive effort by @WilenLab, @johndoench, and generous collaborators. What did we find? #covid19 #CRISPR (1/n) biorxiv.org/content/10.1101/…
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Sad to hear the passing of Beth Levine. She was a luminary in the autophagy field and a phenomenal scientist in so many ways. She motivated and inspired me to be a better scientist. Condolences to her family.
I'm at a loss for words. I want to say how much Dr Beth Levine has inspired me, helped me, was kind to me, even though she barely knew me.. Her passing is a huge loss of the scientific community, and for me personally. She will be sorely missed. @UTSWNews
Great opportunity to hear some top notch virology research and open for everyone!
ASV virtual workshop presentations are June 15-19, 2020 from people whose abstracts had been accepted for #ASV2020. Anyone can sign up to view any virtual workshop at asv.org/virtual-workshops. Do it soon! #LoveVirology