UKRI Future Leaders Fellow & Group Leader @UCL | Pre-cancer Immunology, early detection, immune interception | Ex-swimmer, woeful centre back |
University College London, UK
Joined September 2019
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Thanks for covering the paper @ImmunoPodcast !
Scientists in Dr. @JL_Reading's lab at @UCL found that BATF-expressing regulatory T cells expand across blood and lung tissues during early #LungCancer development. 🫁
More on the study: go.nature.com/4ipKD2d
Listen to the discussion: bit.ly/4ypXvKI
Thanks for highlighting @Immune_News
In this @Nature paper, scientists reveal a conserved effector regulatory CD4+ T cell network that emerges across tissues during early pulmonary #tumorigenesis.
Their work provides a theranostic framework to track and target preinvasive immune regulation for lung cancer interception. Read more in their #OpenAccess article. 👇
🫁 go.nature.com/4ipKD2d
Thanks @EricTopol !
Some biomedical words that ought to grab you:
"a framework to track and target preinvasive immune regulation for lung cancer interception"
New @Nature on regulatory cells to prevent a type of cancer
nature.com/articles/s41586-0…
James L Reading retweeted
Some biomedical words that ought to grab you:
"a framework to track and target preinvasive immune regulation for lung cancer interception"
New @Nature on regulatory cells to prevent a type of cancer
nature.com/articles/s41586-0…
Thanks @Nature
Nature research paper: A preinvasive regulatory T cell axis for lung cancer interception
go.nature.com/4znJhe8
Thanks for highlighting @exosome ! 🤙🏻more to come soon…
Using immunology to catch lung cancer early !
Nature study identified an immunosuppressive regulatory T-cell circuit active during early lung tumor development.
Blocking this circuit reduced tumor incidence and size in experimental models.
doi.org/10.1038/s41586-026-1…
Thanks for highlighting @EricTopol
Some biomedical words that ought to grab you:
"a framework to track and target preinvasive immune regulation for lung cancer interception"
New @Nature on regulatory cells to prevent a type of cancer
nature.com/articles/s41586-0…
James L Reading retweeted
A conserved eTreg cell network emerges across tissues during early pulmonary tumorigenesis @Nature @JL_Reading @uclcancer
nature.com/articles/s41586-0…
James L Reading retweeted
This has truly been a massive collaborative effort! Thanks to all the people in the @kevlitchfield, @SwantonLab, and @QuezadaLab labs, as well as our collaborators @samuels_yardena & lab, @JL_Reading, @JezCarlton , @NickyMcGranahan and other colleagues across @uclcancer.
James L Reading retweeted
Please help spread the word by sharing the above post:
@JL_Reading @alisoneringel @ColindaScheele @JohannesTextor @TsangLab @PeterMKWestcott
James L Reading retweeted
#CancerImmuno speaker list is live!📢
Join us in sunny Lisbon, July 2026. Register now and submit your talk to share your research.
Early Bird Deadline: 15 Jan 2026
👉 Click here to register: bit.ly/4oKzFoN
#FusionImmunology #FusionCancerResearch
🚨 PhD available in our lab 🚨 exploring blood immune multi-omics to detect lung cancer years before clinical diagnosis in a unique cohort of >10k CT screened individuals.
✅ Wet & dry lab
✅ September 2025 enrolment
✅ UK tuition fees only
ucl.ac.uk/medical-sciences/d…
James L Reading retweeted
Nature research paper: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
go.nature.com/4hJsDxd
James L Reading retweeted
Our work on contrastive learning of T cell receptor representations is now out in Cell Systems!
Give SCEPTR embeddings a try for your TCR analysis applications: sceptr.readthedocs.io/en/sta…
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James L Reading retweeted
Today our study of the association between replication timing alterations and mutation acquisition during cancer evolution has been published in @NatureComms
nature.com/articles/s41467-0…
James L Reading retweeted
For all the T cell receptor sequencers out there, the latest version of our analysis pipeline Decombinator 5.0 is live, and now on PiPy for greater ease of installtion ! Thanks to Matt Cowley for a huge amount of work !
pypi.org/project/decombinato…
Another proud PI moment from
June, the lab’s spatial biology guru @andreiinsilico describes the cellular ecosystems regulating T cell surveillance in premalignant lesions during pulmonary carcinogenesis at the @uclcancer conference; all from a blank canvas inside 18 months 👏
Our superstar PhD student @sam__gamble elegantly describing the mechanisms of immune regulation that foster lung cancer development at the roadblock first annual cancer prevention conference @Harvard @CRUKresearch #prevconv24 @uclcancer
This is a truly collaborative effort from an exceptional crop of computationally & experientially gifted PhD students & postdocs working across species, tissue and platform. Huge credit to Sam’s co-lead authors @claudiapeinador @ZoeWhiteman1 @TImp789