Sam Gamble (@sam__gamble) profile picture

Sam Gamble

@sam__gamble

Computational Scientist at Baseimmune

 London, England
Joined June 2024
  • Tweets10
  • Following72
  • Followers21
Sam Gamble retweeted
nature (@Nature) profile picture
nature
@NatureOct 14
Nature research paper: A preinvasive regulatory T cell axis for lung cancer interception go.nature.com/4znJhe8
A preinvasive regulatory T cell axis for lung cancer interception

A preinvasive regulatory T cell axis for lung cancer interception

Nature - An effector regulatory T cell circuit is identified that can be monitored in blood samples to track the development of lung cancer, and blockade of this immune network in the preinvasive...

nature.com
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Sam Gamble retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopolOct 7
Some biomedical words that ought to grab you: "a framework to track and target preinvasive immune regulation for lung cancer interception" New @Nature on regulatory cells to prevent a type of cancer nature.com/articles/s41586-0…
Image from Eric Topol (@EricTopol)
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Very excited to see our work out now in Cancer Cell! And congrats to Evie Fitzsimons for spearheading this effort 🧬 @kevlitchfield @JL_Reading
Cancer Cell (@Cancer_Cell) profile pictureCancer Cell@Cancer_Cell15 Oct 2024
A pan-cancer single-cell RNA-seq atlas of intratumoral B cells dlvr.it/TFNVLL
Image from Cancer Cell (@Cancer_Cell)
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Huge congratulations to Evie and my fellow co-authors on our recent work exploring intratumoral B cells, just published in @Cancer_Cell. Many thanks to @kevlitchfield & @JL_Reading for their hard work and support throughout.
Cancer Cell (@Cancer_Cell) profile pictureCancer Cell@Cancer_Cell15 Oct 2024
A pan-cancer single-cell RNA-seq atlas of intratumoral B cells dlvr.it/TFNVLL
Image from Cancer Cell (@Cancer_Cell)
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Sam Gamble retweeted
Kane Foster (@KaneFos) profile picture
Kane Foster@KaneFos27 Aug 2024
Fantastic paper. One of the clearest articulations that current ML methods *can* solve the TCR specificity problem, if given sufficient data. I remain very surprised at the redundancy of individual positions in epitope sequence without altering T cell activation.
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Does cancer #evolution & intra-tumour heterogeneity predict long-term relapse? We tested the evolutionary paradigm in prostate cancer clinical trials with long follow-up, combining genomics with digital histopathology: nature.com/articles/s43018-0…
Image from Andrea Sottoriva (@AndreaSottoriva)
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Another proud PI moment from June, the lab’s spatial biology guru @andreiinsilico describes the cellular ecosystems regulating T cell surveillance in premalignant lesions during pulmonary carcinogenesis at the @uclcancer conference; all from a blank canvas inside 18 months 👏
Image from James L Reading (@JL_Reading)
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Our superstar PhD student @sam__gamble elegantly describing the mechanisms of immune regulation that foster lung cancer development at the roadblock first annual cancer prevention conference @Harvard @CRUKresearch #prevconv24 @uclcancer
Image from James L Reading (@JL_Reading)
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Sam Gamble retweeted
Kane Foster (@KaneFos) profile picture
Kane Foster@KaneFos25 Jun 2024
Very happy to share our latest pre-print studying T cell dynamics in multiple myeloma disease evolution 🧵1/10. medrxiv.org/content/10.1101/…
Tumour-intrinsic features shape T-cell differentiation through myeloma disease evolution

Tumour-intrinsic features shape T-cell differentiation through myeloma disease evolution

The haematological malignancy multiple myeloma is associated with skewed T-cell activation and function. T-cell alterations are detectable in asymptomatic myeloma precursor conditions and have the...

medrxiv.org
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