John Watters (@JWatts421) profile picture

John Watters

@JWatts421

Graduate Student in @Alushin_Lab & @InLiuOfBulkExps

Joined December 2012
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In this paper published today @MolecularCell, we described an experimental platform that combines single-molecule fluorescence and optical tweezers to visualize RNA polymerase transcribing DNA, which allowed us to study the dynamics of transcription elongation and termination 1/n
Molecular Cell (@MolecularCell) profile pictureMolecular Cell@MolecularCell13 Mar 2023
Online Now: Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination dlvr.it/Skqfmf
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription...

Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription...

Genomic DNA is a crowded molecular highway where motor protein collisions are inevitable. Using a single-molecule visualization platform, Wang et al. investigate the outcome of collisions between...

cell.com
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In this preprint, we developed a single-molecule platform to visualize individual RNA polymerases traveling on DNA, which enabled us to delineate a transcription termination process driven by polymerase collisions. Traffic jams can be useful, at least on a molecular highway!
bioRxiv Biophysics (@biorxiv_biophys) profile picturebioRxiv Biophysics@biorxiv_biophys24 Oct 2022
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination biorxiv.org/cgi/content/shor… #biorxiv_biophys
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A phenomenal athlete, relentlessly optimistic leader, Hanabi savant, and most importantly, a great amigo.
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