Single-molecule aficionados @RockefellerUniv | Low-energy biophysics | High-energy biophysicists | Molecular machines | Chromatin biology | Everything moving
Rockefeller University
Joined February 2021
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Stunning spring scenery 🌿🌸@RockefellerUniv and a perfect moment for group photo 😇 From left to right: Qi Jia, Jieru Li, Xiangwu Ju, Stephany Chuquimarca, Htet Ng, Shixin Liu, Yukun Wang, Masuda Begum, John Watters, Gabriella Chua, Jeremy Chang
LiuLab_Rockefeller retweeted
RIP, Prof. Tsuneko Okazaki, the discoverer of Okazaki Fragment, with late Reiji Okazaki.
岡崎夫妻は分子生物学の黎明期、DNA複製のパラドクス（どうやって3’-5’側の鋳型鎖が複製できるのか）を解明した。「岡崎フラグメント」発見である。
10年ほど前、名古屋大で卓越した若手〜中堅の分子生物学者を表彰する「岡崎賞」を設立することになり、私も少々関わった。恒子先生は、当時、故•岡崎令治教授との共同研究への評価など複雑な心中を語ってくださった。設立委員会で「賞の正式名称はTsuneko & Reiji Okazaki Awardにしませんか？ムーア財団Gordon & Betty Moore Foundation, ゲーツ財団Bill & Melinda Gates Foundationのように、夫婦両方の貢献を可視化するのが国際賞としてふさわしいのでは」と提言した。それを大変喜んでくださったことを記憶している。女性研究者の大先輩でありレジェンド。岡崎恒子博士の冥福をお祈りいたします。#WomenInScience.
nitter.cf/KeikoUTorii/status/104…
Tsuneko & Reiji Okazaki Award committee w/ the legendary JPN molecular biologist, Dr. Tsuneko Okazaki #WomenInSTEM. 伝説の女性分子生物学者、岡崎恒子先生と。
LiuLab_Rockefeller retweeted
Rockefeller's Shixin Liu (@InLiuOfBulkExps) is pioneering new ways of studying the tiny, fascinating proteins that copy and transcribe genetic code.
We spoke to Liu about how this work could shed light on tuberculosis, cancer, and more: bit.ly/4vGE4gn
Have you ever wondered what a car crash would look like at the nanoscale? Check out our latest preprint led by soon-to-be Dr. John Watters! @JWatts421 @Alushin_Lab @RockefellerUniv 🧬🚗
Structural principles of transcriptional collisions biorxiv.org/content/10.64898… #biorxiv_biophys
LiuLab_Rockefeller retweeted
How do you move from static DNA models to real-time mechanics?
Join our next webinar to see how the team of Dr. Xiaolan Zhao @ZhaoLab_SKI at @MSKCancerCenter uses the @LUMICKS_NL C-Trap to decode the molecular determinants of Smc5/6 association with DNA junctions.
#DNArepair #SingleMolecule #DNAreplication #MSKCC
🔗web.lumicks.com/l/970813/202…
LiuLab_Rockefeller retweeted
TPCB congratulates Gabriella Chua (@BadAtCloning) on receiving the 2026 Harold M. Weintraub Award! Gabriella is a recent graduate of the program, and this prestigious honor recognizes her outstanding scientific discoveries throughout her PhD studies. linkedin.com/posts/tpcb_gabr…
Congratulations to all awardees, special shout-out to our own Gabriella Chua @BadAtCloning !! 🎊🔥🍾️ @TPCB_NYC @RockefellerUniv @fredhutch
Huge congratulations to the recipients of the 2026 Weintraub Award! These twelve exceptional graduate students exemplify the bold, creative, and pioneering spirit embodied by Dr. Hal Weintraub. fredhutch.org/en/news/releas…
ALT Top row, left to right: Keene Abbot, Gabriella Chua, Lifei Jiang, Won Jun Kim, Ruchita Kothari and Ayush Midha. Bottom row, left to right: Rohith Rajasekaran, Yusha Sun, Andrea Terceros, Wendy Valencia Montoya, Zachary Walsh and Peter Yoon.
A great pleasure to be part of this exciting work from the Worden and Jones labs @VAInstitute that illustrated how a de novo DNA methyltransferase senses the linker DNA length between nucleosomes to tune its DNA methylation activity. Every physical parameter in chromatin matters!
So pleased to share that our work showing how Nucleosome spacing regulates DNA methylation by DNMT3A2/3B3 has been published today! Excellent collaboration the Jones and Liu labs.
cell.com/molecular-cell/full…
LiuLab_Rockefeller retweeted
Online Now: Nucleosome spacing regulates linker methylation by DNMT3A2/3B3 dlvr.it/TR7vdH
LiuLab_Rockefeller retweeted
In the latest issue! A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis dlvr.it/TR6Xlg
Our collaborative study with @ZhaoLab_SKI on Smc5/6 is published @NatureComms! This work provides insight into the mechanisms for the unique ss-dsDNA junction binding behavior of this versatile SMC complex and its interplay with other factors such as PCNA: rdcu.be/e1Vkt
LiuLab_Rockefeller retweeted
A study in @CellCellPress from Shixin Liu (@InLiuOfBulkExps) and Michael O’Donnell finds that a protein once thought to simply help load a factor necessary for the copying of DNA actually plays a key role in ensuring fast and reliable replication: bit.ly/4qOodK1
Check out our paper @CellCellPress where we visualized the interplay between two key DNA replication factors PCNA & RFC and found an unexpected non-catalytic role of RFC in stabilizing PCNA’s interaction with DNA polymerase and enabling efficient synthesis cell.com/cell/fulltext/S0092…
Led by @BadAtCloning and a fun collaboration with the O’Donnell lab @RockefellerUniv and @ZhaoLab_SKI, this work integrates single-molecule, biochemical and genetic approaches, shedding new light on DNA clamp loading, a process essential for genome replication and maintenance 🧬
LiuLab_Rockefeller retweeted
Interesting interview with scientist Kazuhiko Kinosita Jr: nature.com/articles/422266a
You don't get to read many interviews like this one...
LiuLab_Rockefeller retweeted
Rockefeller researchers Shixin Liu (@InLiuOfBulkExps) and Joel Cohen reveal how key regulatory proteins work in a precise hierarchy to meticulously adjust pacing during transcription.
rockefeller.edu/news/38673-d…
Our work on single-molecule visualization of mammalian transcription elongation is online @NatureSMB today! Check out the open-access paper rdcu.be/eR257 to see how Pol II acts as a multi-speed machine🚗We are thankful for our collaborators @RockefellerUniv @FudanUniv🙏
LiuLab_Rockefeller retweeted
Please check out my essay on the amazing life of Ruth Asawa and her retrospective exhibition at MOMA, released at RockEDU Science Outreach blog site.
rockedu.rockefeller.edu/blog…
LiuLab_Rockefeller retweeted
How many #LaskerAward -winning scientists does it take to figure out how genes express themselves? At least a dozen!
Read about the amazing work—done over decades, by many people, at many institutions—that led to our understanding of gene expression. laskerfoundation.org/how-gen…
@RockefellerUniv @ucsdbiosciences @dgsomucla @MassGeneralNews @salkinstitute @UChicagoMed @harvardmed @MSKCancerCenter @UMassChan
LiuLab_Rockefeller retweeted
🌟 Excited to announce the East Asia Single-Molecule Biophysics Symposium 2025 (EASMB 2025)!
📍 Singapore
🌐 Info & details: physics.nus.edu.sg/easmb2025…
📌 Abstract deadline: Sept 12, 2025
✉️ Register: [email protected]
LiuLab_Rockefeller retweeted
PhD Position Single-Molecule Biophysics
We are seeking a motivated PhD student to use single-molecule techniques and computational tools to explore molecular interactions and apply them for therapeutic applications. Check the call here.
careers.tudelft.nl/job/Delft…