Assistant Professor at UTSW Biochemistry; Jody Puglisi Lab alumnus.
UT Southwestern Medical Center
Joined March 2019
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Excited to share the first paper from our new lab @UTSWMedCenter @UTSWScience ! 🎉 Now out in @NatureComms
Mechanisms of human mitochondrial leaderless mRNA translation initiation
nature.com/articles/s41467-0…
Jinfan Wang retweeted
Today, our work in partnership once again with @SternbergLab presenting the structures of several DRT10 bacterial defense systems and comprehensive analysis of their mechanisms of action is published… very happy!
Great work guys!
nature.com/articles/s41586-0…
Jinfan Wang retweeted
Joseph D. (Jody) Puglisi to Receive the 2027 Ignacio Tinoco Award in Physical Chemistry of Macromolecules
buff.ly/Tg1UYnH
Jinfan Wang retweeted
Mechanisms of human mitochondrial leaderless mRNA translation initiation | Nature Communications nature.com/articles/s41467-0…
Using biochemical reconstitution, single-molecule fluorescence, and cryo-EM, we watched this process unfold in real time. Read more: nature.com/articles/s41467-0…
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Huge thanks to my team and to our dear friend and collaborator Dan Kober 🚀 And thank you to everyone who offered help and support along the way. Our lab @UTSWMedCenter is hiring #postdoc, please reach out if you're interested in our research.
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Jinfan Wang retweeted
Steven McKnight, Ph.D., Professor of Biochemistry at #UTSW, is the 2025 Albert Lasker Basic Medical Research Award (@LaskerFDN) recipient for pioneering work on low-sequence complexity proteins and their impact on cellular organization and disease. bit.ly/4nubH01
Congratulations @DJSiegwart 🎉
Congratulations to #UTSW Professor @DJSiegwart, Ph.D., for being named a fellow of the @AcadofInventors! Discover how his groundbreaking work in developing nanoparticles is revolutionizing treatments for various diseases. bit.ly/3Vwi0EX #futureofmedicine #utswmed
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Jinfan Wang retweeted
First paper of our lab today @Nature by Nussi!
We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! @embl
doi.org/10.1038/s41586-024-0…
Our new findings on how the ribosome couples with the RNA polymerase are summarized in a movie highlighting the dynamics of the process🎞️🎥
Thanks to Clemens Bretscher for the great animations! - behance.net/cbretscher
@embl paper in @biorxivpreprint
biorxiv.org/content/10.1101/…
Jinfan Wang retweeted
Nature research paper: Tracking transcription–translation coupling in real time go.nature.com/3VLPiA7
Jinfan Wang retweeted
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
Jinfan Wang retweeted
It’s great to see our hibernating ribosomes story finally out @NatureComms! Thanks to @jomaa_lab @MedicineUVA and all @EMBL and @EmblImaging people that supported this project. rdcu.be/dWnv6
Happy to share our little discovery with @SimoneMattei19 team on how ribosomes hibernate upside down on mitochondria during cellular stress is now out @NatureComms! A collaboration between @medicineUVA, @EMBL, @EmblImaging, MEMC. Congrats to all authors! nature.com/articles/s41467-0…
Jinfan Wang retweeted
So proud to be your colleague James!! Such an inspiring speech!
“My message to the young people is this: if I can get so close to the stars, you can too.” —Zhijian “James” Chen, 2024 #LaskerAward winner for his discovery of cGAS, an enzyme that senses self and foreign DNA
#Lasker2024 #LaskerLaureate @UTSWMedCenter
Jinfan Wang retweeted
Congratulations to Zhijian “James” Chen, 2024 #LaskerAward winner! – “for the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.” laskerfoundation.org/winners… #Lasker2024 #LaskerLaureate
An important work led by @C_P_Lapointe @puglisilab & Dever lab showing how eIFs1/5 regulate start codon selection via their dynamic interactions with the initiating ribosomal complexes, textbook knowledge here👏👇
eIF1 and eIF5 dynamically control translation start site fidelity biorxiv.org/cgi/content/shor… #biorxiv_biophys
Jinfan Wang retweeted
🎉Our paper quantifying how RNA flows across subcellular compartments is published! 🎉
Read more in the preprint thread ⬇️ The paper contains an improved analysis of RNA flow rates and new collaborative work on DDX3X with @stephenfloor
authors.elsevier.com/a/1jMoV…
@MolecularCell
How does RNA flow through the cell? From their synthesis, chromatin release, nuclear export, ribosome engagement, and eventual degradation, we quantified the lives of human transcripts genome-wide. (1/7)
See @BrendanSmalec and @robertietswaart ‘s preprint
biorxiv.org/content/10.1101/…
