Munich
Joined July 2018
- Tweets49
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- Followers85
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Jory Goldsmith retweeted
Excited to share the pre-print describing our efforts to stabilize the HCMV gB ectodomain in a prefusion-like conformation. We and others have now routinely stabilized class I viral fusion proteins, but class III viral fusogens have been more difficult.
Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation biorxiv.org/cgi/content/shor… #bioRxiv
Jory Goldsmith retweeted
Excited to share our latest publication @ImmunityCP: "Analysis of the Human B Cell Response to HCMV in Top Neutralizers from a cohort of 9,000 Individuals"!
Congrats to @zehner_matthias, @Ashurov_Art and Mira and thanks to all collaboration partners!
sciencedirect.com/science/ar…
Check out my new manuscript reporting the first structures of neutralizing antibodies bound to C. difficile binary toxin!
journals.asm.org/doi/10.1128…
Jory Goldsmith retweeted
Check out our manuscript reporting the structure of the αMβ2 integrin bound to the adenylate cyclase toxin from B. pertussis! cell.com/cell-reports/fullte… Lots of cool new biological insights. Great work from grad student @JoryGoldsmith in collaboration with @maynard_lab!
Jory Goldsmith retweeted
Congrats to @ColleenMulvihi2! Our latest manuscript on the humanization of yeast & GPCRs! Wonderful collaboration with @edward_marcotte & @VincentjjMartin @ut_mbs!
nature.com/articles/s41467-0…
Jory Goldsmith retweeted
Really cool work on an important B. pertussis toxin led by grad student @JoryGoldsmith! Great collaboration with @maynard_lab and more on the way!
Check out this new study from @JoryGoldsmith, Andrea DiVenere, @maynard_lab & @McLellan_Lab
Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes
buff.ly/2ZnhU8k
Jory Goldsmith retweeted
Check out this new study from @JoryGoldsmith, Andrea DiVenere, @maynard_lab & @McLellan_Lab
Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes
buff.ly/2ZnhU8k
Jory Goldsmith retweeted
Thanks @carlzimmer for featuring our role in the development of vaccines for LMICs. NDV-HXP-S contains our second-generation spike protein (HexaPro or S-6P) expressed from an NDV platform developed by Peter Palese and colleagues @IcahnMountSinai
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Jory Goldsmith retweeted
Thanks for the nice introduction! I spent more than two years trying to get S protein stabilized, until identified 2P strategy; then another painful year experiencing a circulation of submission-rejection-editing, with disappointment and tears. But I insisted it’ll be useful!
Why 2 proline (P) substitutions will go down in history.
Introducing 2P's at the beginning of the central helix (CH) stabilized the spike protein's confirmation upon entering cells.
From the Jan 10 #SARSCoV2 sequence, this 2P Δ was incorporated into the mRNA vaccine designs /1
Jory Goldsmith retweeted
Exciting day for structure-based vaccine antigen design! The Pfizer/BioNTech vaccine encodes for the prefusion-stabilized spike that we (@goodwish916) designed back in 2017 (pnas.org/content/114/35/E734…) as part of a collaboration with Barney Graham, @KizzyPhD, @WardLab1, and others.
Jory Goldsmith retweeted
Excited to see our manuscript out in @ScienceMagazine today! The plasmid for HexaPro is available at Addgene (addgene.org/154754/). Great collaboration with @IlyaFinkelstein and Jennifer Maynard, led by postdoctoral fellow Ching-Lin Hsieh.
Scientists have engineered the spike protein of the #SARSCoV2 virus to be more environmentally stable and generate larger yields in the lab. The new design could accelerate the development of desperately needed vaccines and tests for #COVID19. @UTAustin fcld.ly/qgh1f9f
Jory Goldsmith retweeted
Here we report a new SARS-CoV-2 spike variant that expresses 10-fold higher and is more stable than our previous S-2P construct. Should help production of spikes for diagnostics and vaccines. Great collaboration with @IlyaFinkelstein and Maynard lab.
biorxiv.org/content/10.1101/…
Jory Goldsmith retweeted
Great article on the development of the @moderna_tx COVID-19 vaccine and the role my lab played in collaboration with Dr. Barney Graham and his lab at the VRC @KizzyPhD : wired.com/story/moderna-covi…
Jory Goldsmith retweeted
10 µs simulation of the trimeric #SARSCoV2 spike glycoprotein initiated in the closed state with additional loop structures and glycan chains (PDB 6VXX).
Jory Goldsmith retweeted
Check out our manuscript describing camelid nanobodies that neutralize MERS-CoV and SARS-CoV-1 and 2. Collaboration with Xavier Saelens,
Barney Graham, Nico Callewaert @KizzyPhD
biorxiv.org/cgi/content/shor…
Jory Goldsmith retweeted
Check out this cool SARS-CoV-2/COVID-19 animation from @ElaraSystems that uses the spike structure we determined earlier this year with Barney Graham @NIH @KizzyPhD
Jory Goldsmith retweeted
Our (co-inventors @McLellan_Lab) COVID-19 vaccine (spike delivered by @moderna_tx's mRNA) was just injected into the 1st human in phase 1 trial, only 66 days after viral sequence release... a testament to rapid vaccine development for emerging diseases🦠💚
niaid.nih.gov/news-events/ni…
Jory Goldsmith retweeted
Check out this video on coronavirus vaccine design. Had CNN in the lab for 3 hours last week. They were great. Fun to be in a video with my longtime collaborator Dr. Barney Graham @NIH
@UTAustin
m.facebook.com/story.php?sto…
Jory Goldsmith retweeted
Just weeks after the genome sequence of recently emerged #coronavirus—2019-nCoV—was published online, researchers have reported in Science the cryogenic electron microscopy (cryo-EM) structure of the spike (S) protein it uses to gain entry to host cells. fcld.ly/duayfwa
Jory Goldsmith retweeted
Great effort led by grad student Daniel Wrapp and postdoc Nianshuang Wang! 12 days from harvesting media to deposition/submission. Now to test the stabilized spike as a vaccine with Dr. Barney Graham at VRC/NIAID.
biorxiv.org/content/10.1101/…
