Jonathan S. Weissman's lab at the @WhiteheadInst/@MIT. Account run by lab members.
Cambridge, MA
Joined October 2019
- Tweets193
- Following3.5K
- Followers11.4K
- Likes351
Jonathan Weissman's Lab retweeted
I'm also excited to share the first application of MeRN to study metabolic regulation in mouse embryos (including mutants)! Nick Dias of the Smith Lab led this work with me, in collaboration with the @jswlab. Now on bioRxiv! 🧵 1/
biorxiv.org/content/10.64898…
Jonathan Weissman's Lab retweeted
This has been an incredible, collaborative effort co-led with @WilliamNColgan in the @JswLab and with Zach Smith’s group at Yale and the @maxplanckpress and his amazing group members @CAbiologist , Jason Hou, and Minming Wang and our other wonderful collaborators.
Jonathan Weissman's Lab retweeted
A fantastic collaboration with @LukeKoblan! Excited to see what the developmental biology community can learn from these data. Check out our CELLxLINEAGE explorer: mela.wi.mit.edu/explore/
Thrilled to share that our work reconstructing a cell fate map of the mouse embryo is out now in @CellCellPress! doi.org/10.1016/j.cell.2026.…
Jonathan Weissman's Lab retweeted
Excited to share my PhD work, now on @bioRxiv! 🎓🦠Viruses are packed with small ORFs with unknown function. At @JswLab w/ collaborators, we built a pan-viral microprotein atlas that uncovered the oncogenic activity of BNLF2b, an EBV gene linked to cancer.
biorxiv.org/content/10.64898…
Jonathan Weissman's Lab retweeted
📣 new preprint multimodal atlas. Imaging + scRNA, 57M cells. 🧬🔬
Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std?
The answer surprised us 🧵
biorxiv.org/content/10.64898…
Jonathan Weissman's Lab retweeted
What is the global structure of cell-state space—and how do perturbations drive transitions within it?
Excited to share our new preprint (biorxiv.org/content/10.64898…), a work in collaboration with @JswLab.
Jonathan Weissman's Lab retweeted
A few years in the making in the @JswLab with @WilliamNColgan, Zack Smith, and the rest of our fantastic team: Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis. Excited to hear everyone's thoughts!
Excited to share a new preprint from the lab led by @LukeKoblan and @WilliamNColgan in which we describe our efforts to define a quantitative cell fate map of mouse embryogenesis! biorxiv.org/content/10.64898…
Jonathan Weissman's Lab retweeted
Inspired by @JswLab, we generated a mini Genome-wide Perturb-seq, using just two 10x lanes (!).
Far too much data for one tweet (or one Figure), but it works beautifully.
The ability to assess the molecular function of every gene in an afternoon is mind-boggling
Jonathan Weissman's Lab retweeted
Excited to announce that this work is now live as a first release article @ScienceMagazine So grateful for this fantatic team and to see this work in wild! science.org/doi/10.1126/scie…
1/14
On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.1101/…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse model of lung metastasis, we dissect how cell-intrinsic and environmental factors coordinately shape tumor evolution in vivo.
Jonathan Weissman's Lab retweeted
Really enjoyed writing this review on the recently expanded landscape of human outer mitochondrial membrane protein biogenesis, its evolution across eukaryotes, and comparisons to the ER biogenesis systems! @JswLab
nature.com/articles/s41556-0…
Jonathan Weissman's Lab retweeted
Hear it straight from our amazing first author @_annhuang to dive into the X-Atlas/Orion dataset and the FiCS Perturb-seq Platform. Excited to share our work from @Xaira_Thera. (biorxiv.org/content/10.1101/…)
1/12
Excited to share our team's latest work and the first @xaira_thera preprint! Here, we introduce FiCS Perturb-seq, an industrialized platform for generating scaleable, high-quality perturbation data.
📄 Read the preprint: biorxiv.org/content/10.1101/…
Jonathan Weissman's Lab retweeted
1/14
On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.1101/…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse model of lung metastasis, we dissect how cell-intrinsic and environmental factors coordinately shape tumor evolution in vivo.
Jonathan Weissman's Lab retweeted
Delighted to share this preprint from Prof. Rong Fan Lab @RongFan8 and Prof. Sidi Chen lab @sidichen on Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT. Congatulations, Alev, Xiaolong, Feifei, Paul, Sidi and Rong!
Thrilled to share Perturb-DBiT — spatial unbiased in vivo perturb-seq with genome-scale CRISPR libraries! Hope you enjoy reading it over the Thanksgiving week 🥰 Kudos to @AlevBaysoy, Xiaolong, Feifei, and Paul. & collaboration with @sidichen, Hongbo Chi.
biorxiv.org/content/10.1101/…
Jonathan Weissman's Lab retweeted
Excited that the Zhuang Lab is now on X!
Check out our preprint on Perturb-multi (doi.org/10.1101/2024.11.18.6…), a multi-year collaborative effort that enabled multi-modal in vivo genotype-phenotype mapping by pooled genetic perturbations and high-dimensionality phenotype readout by imaging and sequencing.
Jonathan Weissman's Lab retweeted
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
biorxiv.org/content/10.1101/…
Jonathan Weissman's Lab retweeted
Very exciting new work on multimodal, in vivo perturb-seq!
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
biorxiv.org/content/10.1101/…
Jonathan Weissman's Lab retweeted
excited to share COMET! A scalable CRISPR approach we (@carwils) developed to identify multidomain proteins that modulate transcription at specific endogenous genomic loci. @arcinstitute @ucsf
doi.org/10.1101/2024.10.28.6…
Jonathan Weissman's Lab retweeted
There has been confusion over mitochondrial mutation detection, consensus variant calling, and lineage tracing in single cells. Here, we detail how ReDeeM addresses these challenges, improving detection of mtDNA mutations by 10-fold and lineage tracing. Led by @chenweng1991 and @JswLab, we now constructively address concerns raised: biorxiv.org/content/10.1101/…
Stay tuned for 🧵 from Chen.
#genomics #mitochondria #singlecell
Jonathan Weissman's Lab retweeted
Just how impactful are large-scale perturbational data in single cell genomics?
In the last two weeks, there have been *three* modeling/stats preprints with qualitatively different questions and insights for the same dataset generated by @josephmreplogle @JswLab (links below)
Jonathan Weissman's Lab retweeted
It’s been great working with @EdwinNNeumann and @TessaBertozzi for the past 2 years. Grateful I got to be part of such an impactful project and work with amazing people
Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0
science.org/doi/10.1126/scie…
