@JuneWRhee
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Physician-scientist interested in the Heart, Stem Cells, CRISPR, CHIP, and Cardio-oncology @cityofhope
Joined November 2017
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Loved working with and learning from so many #CHIP experts. Grateful for the leadership and guidance of @pnatarajanmd.
The field is rapidly evolving - an incredibly exciting time! Looking forward to future work incorporating #CHIP into clinical care!
@AHAScience
@cityofhope @broadinstitute
Very excited to share our @AHAScience Scientific Statement on Clonal Hematopoiesis and Its Cardiovascular Implications led by @JuneWRhee!
@cityofhope @broadinstitute @MGBResearchNews @harvardmed
June Rhee retweeted
Colchicine reduces competitive advantage of clonal hematopoiesis (esp TET2) in COLCOT ahajournals.org/doi/abs/10.1… @CircAHA
Similar to LoDoCo2 jacc.org/doi/10.1016/j.jacc.… @JACCJournals
Our prior work in mice & human biobanks suggests that colchicine may be effective in reducing TET2 CHIP-associated CVD risk academic.oup.com/eurheartj/a… @ESC_Journals
It should never be a choice between treating cancer or protecting the heart. Our new study in #EHJ, co-led by @zhaowang4695, identified the mechanism of osimertinib cardiotoxicity and a new targeted treatment.
Translational medicine driving innovation in #cardiooncology! Great work, #KaiZhang! @cityofhope
academic.oup.com/eurheartj/a…
June Rhee retweeted
It was an honor to be a part of this fantastic podcast series. You’re a gifted interviewer who leads by example. @cityofhope and the countless mentees you’ve influenced are fortunate to have you.
A touching conversation with @ArmenianSaro, our Chair of #PediatricOncology, on the @cityofhope podcats. Despite years of knowing him, had no idea the personal connection he had to the field.
Listen here:
podcasts.apple.com/us/podcas…
June Rhee retweeted
In this exploratory analysis, Tx w/ low-dose colchicine was assoc w/ an attenuated annual clonal growth in TET2 CH. Findings suggest potential for colchicine to curb proliferative advantage of key CH driver mutations jacc.org/doi/10.1016/j.jacc.…
#ESCCongress #WCCardio #JACC @mchonig
New chapter in our #CH journey!
In 1,931 auto-HCT pts, CH was linked to a 2-fold ↑ risk of nonmyeloid subsequent cancer (SIR = 1.9). In multivariable analysis, CH remained an independent risk factor (HR = 1.72, 95% CI 1.15–2.59). Beyond CVD, CHIP shapes long-term solid cancer risk among autologous HCT recipients. @ArmenianSaro @cityofhope academic.oup.com/jnci/advanc…
In our recent studies, CHIP was common (~20%+) in our cohort of HCT recipients & associated with markedly ↑ risk of non-relapse mortality. CVD however didn’t fully explain the risk… so we asked: does CHIP also predispose to secondary cancers after HCT?
June Rhee retweeted
A true legend in the field of hematology/oncology. Dr. Stephen Forman was involved in the seminal studies of BMT for hematologic malignancies & evolved into a pioneer of CAR-T cell therapy. There are literally dozens of faculty at @cityofhope & beyond who consider him to be their most influential mentor. This podcast is a must-listen! @TDorffOnc @SaulPriceman @ArmenianSaro @stacywgray
Could radiation be the key to unlocking CAR T cell therapy’s full potential? On the new episode of On the Edge of Breakthrough: Voices of Cancer Research (w/ @montypal), Dr. Forman breaks down how combining radiation with CAR T could enhance impact. Full episode coming 7/22.
June Rhee retweeted
Germline genetic variation has been linked to both hematologic cancer and clonal hematopoiesis. But does germline variation influence the likelihood of CH progressing to cancer? And if so, why? We tackle these questions here in @NatureGenet
nature.com/articles/s41588-0…
June Rhee retweeted
Also deeply thankful to @AlexBickMDPhD, @pnatarajanmd, @jrblundell, @nilanjan10c, @carolinewatson, @hamish_macg, @DrFlashHeart, @yincaoScD, @bloodgenes, and many others for their incredible collaboration and support!
Please see the full author list here 👇
June Rhee retweeted
We’re honored to welcome world-renowned microbiome expert Kenya Honda, M.D., Ph.D. and his research team, to @cityofhope. In partnership with @KeioGlobal, this global collaboration will advance microbiome science and speed breakthroughs in immune-based therapies.
Huge congratulations @RamaNatarajan. Well deserved and can’t think of any better person for this!
Congrats to my mom @RamaRNatarajan for being named a WEILD (Women Elevating and Inspiring Leadership in Diabetes) Trailblazer!
womenleadingdiabetes.com/dia… @cityofhope
June Rhee retweeted
🚨 New paper in @NatureGenet !
How does cancer chemotherapy reshape the HSC landscape and drive the evolution of therapy-related myeloid neoplasms? We uncovered this process through single-colony WGS! See the full paper here! nature.com/articles/s41588-0…
June Rhee retweeted
For all your BCVS related news, check out the latest Basic Beat newsletter that should have arrived in your inbox this week. If not, this is your sign to sign up for an AHA membership and to select BCVS as your council of choice!
Today, I wanted to post something personal so that I can remember :)
Today is a bitter sweet day to say goodbye to our wonderful lab manager and RA, Brittany, as she moves on to the next chapter of starting her dental school!
I’m so thankful for everything she did for the lab. She will be an excellent dentist and researcher :) Wishing her the best!! @zhaowang4695 @ArmenianSaro
