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Jungmann Lab (@JungmannLab) profile picture

Jungmann Lab

@JungmannLab

Our group at @LMU_Muenchen and @MPI_Biochem uses DNA nanotechnology to develop next-generation super-resolution microscopy techniques. #DNAPAINT

 Munich, Germany
biochem.mpg.de/jungmann
Joined May 2023
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Photo by Jungmann Lab (@JungmannLab)Photo by Jungmann Lab (@JungmannLab)Photo by Jungmann Lab (@JungmannLab)Photo by Jungmann Lab (@JungmannLab)Photo by Jungmann Lab (@JungmannLab)Photo by Jungmann Lab (@JungmannLab)Photo by Jungmann Lab (@JungmannLab)Photo by Jungmann Lab (@JungmannLab)Photo by Jungmann Lab (@JungmannLab)Photo by Jungmann Lab (@JungmannLab)
Glad to announce that Picasso v0.10.0 is out! - ⚡️ GPUfit built in for localization (Windows) - New fast fitting methods in SPINNA - ThunderSTORM .csv import directly in Render - Vastly extended API - And many, many more… Visit our page to find out: github.com/jungmannlab/picas…
GitHub - jungmannlab/picasso: A collection of tools for painting super-resolution images

GitHub - jungmannlab/picasso: A collection of tools for painting super-resolution images

A collection of tools for painting super-resolution images - jungmannlab/picasso

github.com
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Jungmann Lab retweeted
Philipp Steen (@PhilippSteen) profile picture
Philipp Steen@PhilippSteenJan 26
How do you scale super-resolution microscopy to dozens of proteins without linearly scaling imaging time? We introduce Combi-PAINT: a combinatorial DNA-PAINT strategy that breaks the 1-target-per-round bottleneck of Exchange-PAINT: biorxiv.org/content/10.64898… 1/5
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#pictureofthemonth: The pic shows 30 different protein types with spatial resolution in a neuronal "atlas“ created with the imaging method SUM-PAINT. Find out more: biochem.mpg.de/jungmann November – institute calendar of @MPI_Biochem and @MPIforBI Image by Eduard Unterauer
Image from Max Planck Institute of Biochemistry (MPIB) (@MPI_Biochem)
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Now online: October 2025 Issue. - Focus Issue on #biosensing - DNA moiré superlattices - Sugars at Ångström-resolution - Solid-state #nanopores - Non-aqueous Li #batteries - Neuromorphic vision - Peptide #hydrogels - Deep learning for #LNPs & more. nature.com/nnano/volumes/20/…
The image on the cover shows two sugars from the same cell-surface glycan separated by 9 Å, visualized with RESI (resolution enhancement by sequential imaging) enabled by metabolic labelling with DNA barcodes. IMAGE: Luciano A. Masullo, Max Planck Institute of Biochemistry, Germany. COVER DESIGN: Vanitha Selvarajan Original paper: Masullo, L.A., et al. Ångström-resolution imaging of cell-surface glycans. Nat. Nanotechnol. 20, 1457–1463 (2025). https://doi.org/10.1038/s41565-025-01966-5 Abstract: Glycobiology is rooted in the study of monosaccharides, ångström-sized molecules that are the building blocks of glycosylation. Glycosylated biomolecules form the glycocalyx, a dense coat encasing every human cell with central relevance—among others—in immunology, oncology and virology. To understand glycosylation function, visualizing its molecular structure is fundamental. However, the ability to visualize the molecular architecture of the glycocalyx has remained challenging. Techniques

ALT The image on the cover shows two sugars from the same cell-surface glycan separated by 9 Å, visualized with RESI (resolution enhancement by sequential imaging) enabled by metabolic labelling with DNA barcodes. IMAGE: Luciano A. Masullo, Max Planck Institute of Biochemistry, Germany. COVER DESIGN: Vanitha Selvarajan Original paper: Masullo, L.A., et al. Ångström-resolution imaging of cell-surface glycans. Nat. Nanotechnol. 20, 1457–1463 (2025). https://doi.org/10.1038/s41565-025-01966-5 Abstract: Glycobiology is rooted in the study of monosaccharides, ångström-sized molecules that are the building blocks of glycosylation. Glycosylated biomolecules form the glycocalyx, a dense coat encasing every human cell with central relevance—among others—in immunology, oncology and virology. To understand glycosylation function, visualizing its molecular structure is fundamental. However, the ability to visualize the molecular architecture of the glycocalyx has remained challenging. Techniques

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Our article "Ångström-resolution imaging of cell-surface glycans" on the cover of Nature Nanotechnology! 🤩 @NatureNano nature.com/nnano/volumes/20/…
Image from Luciano A. Masullo (@l_masu)
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Thrilled to announce some big news! I’ve been awarded a Wellcome Trust Early Career Award to establish my research as a Group Leader in the Glycosciences Program at the Institute of Biology and Experimental Medicine (IBYME) in Buenos Aires, Argentina, starting early 2026.
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Jungmann Lab retweeted
Leonhard Möckl (@LMoeckl) profile picture
Leonhard Möckl@LMoeckl28 Jul 2025
Very happy to see this one out - the first molecular-resolution imaging of glycocalyx components in their native environment! Great collaboration with @jungmannlab - congrats to first authors @KarimAlmahayni and @l_masu and to the whole team!
Nature Nanotechnology (@NatureNano) profile pictureNature Nanotechnology@NatureNano28 Jul 2025
Now online: Ångström-resolution imaging of cell-surface glycans. The molecular organization of sugars in the native #glycocalyx has been resolved at 9 Å using bioorthogonal metabolic labeling & #superresolution imaging of DNA barcodes. #Glycotime nature.com/articles/s41565-0…
Ångström-resolution imaging of cell-surface glycans

Ångström-resolution imaging of cell-surface glycans

Nature Nanotechnology - By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the...

nature.com
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Congratulations to Ralf on your election as a new EMBO member: ❕Original press release from @EMBO: embo.org/press-releases/outs…
Image from Max Planck Institute of Biochemistry (MPIB) (@MPI_Biochem)
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Subcellular spatial proteomics is the subject of a Method to Watch by @rita_strack, who discusses how advances in multiplexed super-resolution microscopy will facilitate this. nature.com/articles/s41592-0…
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The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳 For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread. nature.com/articles/s41592-0…
Image from Nature Methods (@naturemethods)
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New protein labelling SUM-PAINT enables high throughput, high res, multiplex imaging 📷: @EduardUnterauer, Sayedali Shetab Boushehri & Kristina Jevdokimenko et al @euforna @uniGoettingen @JungmannLab @MPI_Biochem in @CellCellPress ➡️: bpod.org.uk/archive/2024/11/… with @AntDLewis
Image from Biomedical Picture of the Day BPoD (@BPoD_s)
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At the end of the PhD journey, you realize the goal was actually only part of the deal. It’s the people you get to know along the way and the experiences you share that shape you to become a wiser and happier human being. Thanks for the great time @JungmannLab
Image from Eduard Unterauer (@EduardUnterauer)
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We are live at the @LMU_Muenchen Physics Science Fair! Come to our poster to learn about what we do at the @JungmannLab! We have several research projects for students at Bachelor and Master level!
Image from Luciano A. Masullo (@l_masu)
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Jungmann Lab retweeted
Erdinc Sezgin (@Sciezgin) profile picture
Erdinc Sezgin@Sciezgin7 Oct 2024
What a start with the one and only @JungmannLab !!
Sandrine LévêqueFort (@S_LevequeFort) profile pictureSandrine LévêqueFort@S_LevequeFort7 Oct 2024
Start of the workshop "High Resolution 3D Microscopy in Biology: Development & Applications", co-organized by @GDR_ImaBio @Fr_BioImaging, happy to welcome @JungmannLab @Sciezgin Sophie Brasselet @Gaelle_Recher @LydiaDanglot @wsupatto, and to host the event at @ISMOlab_Orsay
Image from Sandrine LévêqueFort (@S_LevequeFort)
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Jungmann Lab retweeted
Rita Strack (@rita_strack) profile picture
Rita Strack@rita_strack11 Sep 2024
Obviously I am biased, but @naturemethods is 🔥🔥 this week
Image from Rita Strack (@rita_strack)
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1st place poster prize for the wonderful PhD student @rafalkowalew !!! 🥇🥳🤩 @JungmannLab #SMLMS2024 btw, he is *the* guy now behind PICASSO software, developing and maintaining it 🧬🎨
Image from Luciano A. Masullo (@l_masu)
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Out today from the @JungmannLab! A comprehensive comparison of how 18 different dyes perform in DNA-PAINT along with optimized guidance for dye selection and multiplexed imaging. nature.com/articles/s41592-0…
Image from Nature Methods (@naturemethods)
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I am delighted to announce I have won the MAPS Faculty ECR Forum Award 2024 for Outreach and Communication. As someone who understands the need for widening participation in science, this award is very close to my heart. For more info: ucl.ac.uk/mathematical-physi…
Image from Megan Joseph, PhD (@MDJoseph97)
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Looking at this beautifully detailed neuron, stained for 9 different proteins using SUM-PAINT, feels like stepping into one of David S. Goodsell's paintings illustrating the crowded cellular environment. #FluorescenceFriday #phdlife @JungmannLab
Image from Eva-Maria Schentarra (@EvaSchentarra)
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Ready to present the SUM-PAINT story at the single molecule approaches to biology @GordonConf in beautiful Maine 😊. If you are interested, stop by Wednesday or Thursday 🙂
Image from Eduard Unterauer (@EduardUnterauer)
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