Process Chemist at Abbvie since 2015. Father of five. Opinions are my own.
Joined September 2018
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This was a really cool project. Awesome to see it in p rint
figshare.com/collections/Sca…
kaid harper retweeted
Final version appearing today in @NatureChemistry : nature.com/articles/s41557-0…
Aminoalcohols are expressed in natural products, blockbuster pharmaceuticals, agrochemicals, and key building blocks for innumerable society-benefitting applications. See how a departure from polar bond analysis can radically simplify access to these structures on small or large scale. Appearing today in @ChemRxiv : chemrxiv.org/engage/chemrxiv…
Combined with our previous disclosure (pubs.acs.org/doi/full/10.102…), nearly any stereo- or regioisomer of these important structures can be accessed quickly and easily.
kaid harper retweeted
The final version of this work was published in @NatureChemistry : nature.com/articles/s41557-0…
Anomeric Amides to the rescue! Halogenate even the most stubborn systems with a new class of reagents. Appearing today in @ChemRxiv - a fun collaboration with Abbvie, BMS and Pfizer. chemrxiv.org/engage/chemrxiv…
kaid harper retweeted
Aminoalcohols are expressed in natural products, blockbuster pharmaceuticals, agrochemicals, and key building blocks for innumerable society-benefitting applications. See how a departure from polar bond analysis can radically simplify access to these structures on small or large scale. Appearing today in @ChemRxiv : chemrxiv.org/engage/chemrxiv…
Combined with our previous disclosure (pubs.acs.org/doi/full/10.102…), nearly any stereo- or regioisomer of these important structures can be accessed quickly and easily.
kaid harper retweeted
Published today in @ScienceMagazine : science.org/doi/epdf/10.1126…
Radical retrosynthesis strikes again. Primary RAEs can be mixed and matched with tertiary RAEs or olefins to make quaternary centers with a comical level of simplicity. Check out these applications. A fun collaboration with the great and powerful @Shenvi_Lab: tinyurl.com/7heyrvka
kaid harper retweeted
Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation doi.org/10.1021/acs.oprd.3c0…
kaid harper retweeted
Our investigation into the photomediated ring contraction of saturated heterocycles is out in @J_A_C_S! Excited to finally share my inaugural 1st author, multi-part story that blends synthesis, mechanistic & wavelength-dependent insight, and computations.
tinyurl.com/hccapy9d
kaid harper retweeted
We're absolutely thrilled that our robotic platform, #RoboChem, has been published in @ScienceMagazine!
🔗science.org/doi/10.1126/scie…
#RoboChem can carry out your substrate scope and provide tailored reaction conditions for every single entry. 🤖
#FlowChemistry #photocatalysis
kaid harper retweeted
Do you find this as fascinating as we do? Electrochemical oxygen-atom transfer – same catalyst oxidizes same substrate at the cathode (O2) and anode (H2O). Dioxygenase reactivity w/ electrochemical energy as the only input. Nicely done, Asmaul and James! tinyurl.com/3xwccpps
Our work on scaling electrochemistry via constant potential is out. Give it a look
A Scalable Solution to Constant Potential Flow Electrochemistry | ChemRxiv - go.shr.lc/3SduoJ9
kaid harper retweeted
Anomeric Amides to the rescue! Halogenate even the most stubborn systems with a new class of reagents. Appearing today in @ChemRxiv - a fun collaboration with Abbvie, BMS and Pfizer. chemrxiv.org/engage/chemrxiv…
kaid harper retweeted
Organic Syntheses announces the election of Nathan Ide, Senior Director, Process at AbbVie, to the OS Board of Editors.
kaid harper retweeted
2023 ACS #HeroesofChemistry Winners Announced! Congrats to @abbvie, @honeywell, @Incyte, @Merck, @VertexPharma, & @ViiVHC for developing products that led to advancements in improving #health & the #environment. Learn more at fal.cn/3A1aE #Chemistry #Science
kaid harper retweeted
Exciting new work from @abbvie process chemistry!
I'm very excited to share a unique reaction discovered at #abbvie! We found that thiols and halogenated heterocycles can react, in the absence of base, light or transition metal, under a mechanism we term Proton Transfer Dual Ionization (PTDI) SNAr.
chemrxiv.org/engage/chemrxiv…
Proud to announce our 2000 Watt output blue laser has arrived and is ready to do some serious photochemistry scale-up. This thing is a beast.
For this interesting olefination reaction the Baran group developed, we executed 1-kg batch alternating polarity electrolysis. Check it out.
chemrxiv.org/engage/chemrxiv…
kaid harper retweeted
Such a fantastic day to have the AbbVie-Northwestern Symposium @NUChemistry. We’re delighted to have Prof Dave @NicewiczLab and Dr. Stephen Lathrope deliver two fantastic @abbvie Lectures, followed by engaging poster discussions, and AbbVie info session.
Organic chemists should place their trust in machine learning’s black box: chemistryworld.com/opinion/o…
Finally, lets take the bias out of published reactions and create useable information for the future. I'm excited for the new reactivity we'll discover if we apply these principles. pubs.acs.org/doi/10.1021/acs…