Enzyme designer // Postdoc @ Novonesis & DTU
Copenhagen, Denmark
Joined September 2022
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Anna and Sam are X-less but they’ve done some excellent work with this project. It’s a very exciting time for enzyme designers!
New research in Science represents a notable step forward in designing enzymes from scratch.
With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins.
Learn more: scim.ag/4hU7O1H
Kiera Sumida retweeted
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
Kiera Sumida retweeted
I'm sharing my story in a difficult time for Palestinians and Lebanon, where we found refuge after being exiled from Haifa. I want to honor those who suffered the most and never got to live out their dreams—my grandparents, Jido Ali and Taita Khadejeh. I hope they’re proud (1/3)
The first episode of @BakerLabPodcast is live. Meet Mohamad Abedi, who went from being a Palestinian refugee to a postdoctoral researcher. His journey proves that science can be a creative and transformative process.
Apple: podcasts.apple.com/us/podcas…
Spotify: open.spotify.com/show/32pWWp…
Kiera Sumida retweeted
Here’s our human protein-protein interactome. We mined the SRA, devised a new distillation dataset for protein complexes, trained a new version of RF2 to screen millions of protein pairs, and identify > 18k binary interactions. biorxiv.org/content/10.1101/…
Kiera Sumida retweeted
ML for the de novo design of serine hydrolases
Anna Lauko Samuel Pellock @KieraSumida @DaveJuergens
Our paper using ProteinMPNN redesign for improved properties is up on JACS! Huge thanks to Reyes, @ikalvet, Sam, and many others for their work. Shout out to @JustasDauparas for developing such a groundbreaking (and versatile!) tool. @UWproteindesign
pubs.acs.org/doi/full/10.102…
@ikalvet performed sequence redesign and limited backbone remodeling on human myoglobin to great effect. Higher yields and thermostability leading to retention of heme binding at 95C!
Stability issues bringing you down? Try ProteinMPNN!
Our preprint describing sequence redesign of natural proteins with ProteinMPNN for improved properties is up. Check it out:
biorxiv.org/content/10.1101/…
