💙E3 Ubiquitin ligases and Protein Quality Control: mechanisms, functions and relevance for aging-related diseases, in particular neurodegeneration
Heidelberg, Germany
Joined May 2019
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The Mother of All Ribosome Collisions
Life before #ubiquitin: B. subtilis MutS2/RqcU senses translational stalls that lead to #ribosome collisions, then elicits degradation of the incomplete nascent-chains. Excited to share our findings, online @Nature today.
#RQC
A team of researchers led by ZMBH's PIs C. Joazeiro @LabJoazeiro and S. Pfeffer @PfefferCryoLab discovered how the bacterial MutS2 protein prevents damage by stalled ribosomes! Further details in Nature nature.com/articles/s41586-0…
A Tenure Track Professorship at the ZMBH in Heidelberg, Germany, has just been advertised, (18 January 2026 deadline)
nature.com/naturecareers/job…
I encourage excellent candidates in the broad #proteostasis and/or translation fields to apply! @scijobs @sciencejobs_eu
With this new funding, we’re hiring PhDs and #postdocjobs
Our #ERCAdG studies on the role of #RQC #ribosome #ubiquitin in #neurodegeneration will include using iPSCs, i-neurons, mammalian TC. The lab also has ongoing projects on #mitochondria and bacterial RQC.
Thrilled and honored to receive the #ERCAdG! This will fund us for the next 5 yrs for groundbreaking research
My project SuTra focuses on the Surveillance of Translation, from sensing #ribosome stalling to #RQC. We aim to learn how defective surveillance causes neurodegeneration
📣 Good news: 281 top researchers have just won ERC Advanced Grants!
The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme.
Read more 👉 europa.eu/!JYKxkD
#ERCAdG #FrontierResearch @EUScienceInnov
Thanks, Ino! Thanks also to the LS1 panel for a constructive, fun interview! And congratulations to all fellow awardees! #ribosome #RQC #ubiquitin nitter.cf/inoagrafioti/status/19…
Thanks for your many contributions, Ivan. And of course, we would not have known about this amazing venue had you not pioneered meetings here.
Impressive #EMBOubiquitin24 in #Cavtat with more than 300 participants & active discussions at posters. Superb success- thx to the organisers @MerblYifat76992, @YKulathu, @LabJoazeiro, @polosimona1, @EMBOevents 🙌👏🫶👍
The hotel and weather matched the quality of science 😊
Thanks, Shalini. Your talk was awesome!
Grateful to connect and learn from the great minds in ubiquitin, proteostasis and organelle quality control! Such a well-organised event! #EMBOubiquitin2024
Congratulations to my stellar (ex) PhD student Federico and all the awardees and honorable mentions for this achievement!
honourable mentions: Christian Baca from @RockefellerUniv, Federico Cerullo from ZMBH Heidelberg (@UniHeidelberg), Pascal Devant from @Harvard, Leonard Ernst from @mpi_marburg @maxplanckpress 9/
Federico followed up on our discovery that bacteria also have an RQC pathway. In collab w @PfefferCryoLab, he elucidated mechanisms underlying Ala-tailing by RqcH (the homolog of Rqc2/NEMF), and discovered a factor that senses collided ribosomes upstream of RQC (hence, RqcU).
Joazeiro Lab retweeted
Don’t miss our next free virtual networking events in July! Will be fantastic ☺️
Joazeiro Lab retweeted
Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.
Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda researchsquare.com/article/r…
#CryoEM staff scientist position with awesome PI, doing exciting research, in great place. Apply! 🇨🇭🇨🇭🇨🇭
🔬 Join us at EPFL's School of Life Sciences as a Staff Scientist Expert in Cryo-EM! Work with cutting-edge facilities, collaborate with top researchers, and drive groundbreaking discoveries in structural biology. Apply now: ch.indeed.com/viewjob?jk=b45… #ScienceJobs #CryoEM #EPFL
Joazeiro Lab retweeted
Check out our new preprint: researchsquare.com/article/r…
A fantastic team effort, thanks to Jonas Duering + Madita Wolter, and our spectacular collaborators. Massive thanks to all the people involved in this work!
Joazeiro Lab retweeted
Excited to share the final product of this work, now available at @MolecularCell. Extremely proud of @tylergfranklin for this and many other achievements during his thesis work!
sciencedirect.com/science/ar…
What can bacteria teach us about #ubiquitin? A lot!
In our latest preprint, @tylergfranklin set out to understand how secreted bacterial ligases catalyze ubiquitin modifications during infection. What he found will surprise you!
biorxiv.org/content/10.1101/…
re-tweeting announcement with fixed typo
We're excited with our line up of speakers for the FASEB #Ubiquitin meeting in June 2024! Join us in Niagara Falls to hear stories ranging from ubiquitin signaling and mechanisms to #RQC and targeted protein degradation (#TPD #protacs #molecularglues)
Please join us this summer as the power of Ubiquitin Signaling converges with the power of Niagara Falls for @FASEBorg #UBPSRC. We value DEIA, are raising $ for travel awards, have fantastic speakers and are excited to select new speakers from abstracts. @LabJoazeiro
Joazeiro Lab retweeted
New work from the lab @NatureAging! 🌱🌱 We asked whether the ability of plants to suppress pathological protein aggregation can be applied into human cell and animal models to delay or even prevent neurodegenerative diseases
nature.com/articles/s43587-0…