Biologist, Professor @CECAD_ @UniCologne @UKKoeln. We study aging, age-related diseases, stem cell biology and proteostasis. @thevilchezlab.bsky.social
CECAD Cologne, Germany
Joined July 2013
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New work from the lab @NatureAging!❄️Lowering body temperature extends #longevity. We find that cold-induced #proteostasis prevents #aging and aggregation of proteins that cause age-related diseases #ALS #HuntingtonDisease in C. elegans and human cells nature.com/articles/s43587-0…
Worms live longer in cool conditions thanks to a muscle-derived molecule nature.com/articles/d41586-0…
1/6 ❄️ Very happy to share our new study: “Cold activates a BH2 metabolic network promoting longevity and proteostasis.”
nature.com/articles/s41586-0…
#Aging #Longevity #Proteostasis #Metabolism #ALS #HuntingtonsDisease
5/6 Huge thanks to all co-authors, especially my current and former lab team: Hyun Ju Lee, @dcansu8 @sedakoyuncu12 , Markus, Wehrmann, Dunja Petrovic, Amit Kumar Sahu and Rute Loureiro. Thanks also to Murat Artan and Thorsten Hoppe for their invaluable support and collaboration.
6/6 1000 thanks to @FrezzaLab and his team—their metabolomics contribution was critical to this work. So happy to have Christian @CECAD_ , @UniCologne/@UKKoeln!
Thanks also to the DFG and our Research Unit FOR 5762 for supporting this project.
Bridging omics and physiology to build multimodal clocks of human aging: Cell cell.com/cell/fulltext/S0092…
David Vilchez retweeted
Really proud of this collaborative work exploring how fungal effectors exploit prion-like domains to access plastids and influence plant metabolism during symbiosis. Great to see the PEPSI–DXR story come together. @neto_flames @JohanaMisas @TheVilchezLab
biorxiv.org/content/10.64898…
Our new review on proteostasis of organelles in aging & disease is now online in The FEBS Journal! We discuss recent insights on how #proteostasis safeguards organelle integrity and function across the cell in #aging and disease doi.org/10.1111/febs.70439
The review covers proteostasis mechanisms across major organelles: • Nucleus • Mitochondria • Endoplasmic reticulum • Golgi apparatus • Lysosomes We also highlight proteostasis in membraneless organelles: • Stress granules • P-bodies • Nucleolus • Nuclear speckles
Great collaborative effort by: Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, and Seda Koyuncu
@CECAD_
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
nature.com/articles/s43587-0…
We also discovered that the deubiquitinase USP4 leads to EPS8 accumulation during aging.
Reducing USP4 prevented EPS8 accumulation, extended lifespan, and lessened disease effects.
👉 Targeting EPS8/USP4 could open new therapeutic strategies for neurodegeneration.
A titanic effort from Seda and the lab in collaboration with Nuria Flames’ lab @sedakoyuncu12 @CECAD_ @UniCologne @UKKoeln @IBV_CSIC @NatureAging
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com…
We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/jo…
Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding! #aging #proteostasis
cecad.uni-koeln.de/outreach/…
