Love stem cells, calcium, aging, and metabolism.
Joined January 2019
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Cansu Doğan retweeted
In nematodes, a metabolite induced by the cold links low temperatures to a body-wide signal that promotes longevity
go.nature.com/3UIGTjk
Cansu Doğan retweeted
1/6 ❄️ Very happy to share our new study: “Cold activates a BH2 metabolic network promoting longevity and proteostasis.”
nature.com/articles/s41586-0…
#Aging #Longevity #Proteostasis #Metabolism #ALS #HuntingtonsDisease
Cansu Doğan retweeted
Worms live longer in cool conditions thanks to a muscle-derived molecule nature.com/articles/d41586-0…
Cansu Doğan retweeted
5/6 Huge thanks to all co-authors, especially my current and former lab team: Hyun Ju Lee, @dcansu8 @sedakoyuncu12 , Markus, Wehrmann, Dunja Petrovic, Amit Kumar Sahu and Rute Loureiro. Thanks also to Murat Artan and Thorsten Hoppe for their invaluable support and collaboration.
Cansu Doğan retweeted
This week is Postdoc Appreciation Week and we’re grateful for the BARI postdocs who keep our science moving! You bring the experiments, the ideas, the late nights, and the questions that push aging biology forward. Thank you for being such a vital part of this community!
Cansu Doğan retweeted
Check out Dengke Ma in Science Advances: His team built a sensor (GENTIS) that tracks ionic stress in living animals and discovered that proton buildup in the gut drives sleep during molting in C. elegans. A striking link between cellular ion dynamics and behavioral quiescence.
Cansu Doğan retweeted
Bridging omics and physiology to build multimodal clocks of human aging: Cell cell.com/cell/fulltext/S0092…
Cansu Doğan retweeted
In the latest issue! Bridging omics and physiology to build multimodal clocks of human aging dlvr.it/TTXQ0N
Cansu Doğan retweeted
Huge congrats to BARI Director Leanne Jones on her induction into the Academy of Geroscience! One of 16 leading scientists recognized for advancing the biology of aging. Proud to see her recognized for driving discoveries for healthier longevity! prnewswire.com/news-releases…
Cansu Doğan retweeted
Excited to share a new preprint from our lab: We identify calcium influx at ER-plasma membrane contact sites as a key mechanism regulating brown adipocyte thermogenesis and metabolic health.
biorxiv.org/content/10.64898…
Cansu Doğan retweeted
🚨We’re getting down to the wire!🚨 We need 75 more gifts to unlock the final $57,000 in #CalBigGive matching funds. Every gift—no matter the size—helps us reach our goal. Join our final push by making your gift before 9 pm: givingday.berkeley.edu/givin…
Cansu Doğan retweeted
Our new review on proteostasis of organelles in aging & disease is now online in The FEBS Journal! We discuss recent insights on how #proteostasis safeguards organelle integrity and function across the cell in #aging and disease doi.org/10.1111/febs.70439
Cansu Doğan retweeted
Toxic protein aggregation is a hallmark of Huntington's, ALS, Parkinson's… and enhancing the cell’s natural protein-clearing machinery is a promising therapeutic avenue.
@TheVilchezLab at CECAD/University of Cologne studies how protein homeostasis breaks down with age and how stem cells maintain proteome integrity where somatic cells fail.
We funded them via @impetusgrants to study toxic protein accumulation and discover ways to reduce those protein aggregates.
@TheVilchezLab's Nature Aging paper (supported by @impetusgrants) showed that cold temperature selectively activates PA28γ/PSME3, a proteasome activator required for cold-induced longevity. This reduced disease-related protein aggregation in both C. elegans and human cell models of Huntington's and ALS.
His team continues to explore how we might harness these proteostasis mechanisms to prevent age-related neurodegeneration.
Glad to support this work!
Cansu Doğan retweeted
Look at those beautiful mitochondria (red) surrounding a lipid droplet in a liver cell!
Cansu Doğan retweeted
Trilled to share our new work🥳We show that age-related hyperactivation of the EPS8/RAC signaling pathway drives protein aggregation and neurodegeneration — hallmarks of Huntington’s disease and ALS. #proteostasis #aging #neurodegenerativediseases
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
nature.com/articles/s43587-0…
Cansu Doğan retweeted
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com…
Cansu Doğan retweeted
Congratulations to @BerkeleyMetBio professor @apsarruda and postdoc @AlexInague, who each received multiyear grants from @pewtrusts to support their research and professional growth. Read more: linkedin.com/pulse/two-nst-r…
Cansu Doğan retweeted
How do cells clean up misfolded proteins when they divide?
This study finds that the cleanup crew includes the ER chaperone BiP and the proteasome, and kicks in right as cells finish dividing. Surprisingly, one major cell cycle regulator isn’t involved.
elifesciences.org/articles/9…
I just donated to help recover from a devastating fire that destroyed a local farm's essential structures. Every bit counts. Please consider giving or sharing to support their recovery. gofund.me/a59ee620
Cansu Doğan retweeted
“Now more than ever, science is essential for addressing complex global issues,” writes @BerkeleyMetBio professor @apsarruda. Learn more about her career path—and advice for new scientists—in our spring magazine. nature.berkeley.edu/breakthr…