Head of the Protease Pathophysiology Lab at the Bio21 Institute, University of Melbourne.
Melbourne, Australia
Joined June 2018
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The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.
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Laura Edgington-Mitchell retweeted
Online now! Advances in degradomics technologies to assess proteolytic cleavage events dlvr.it/TQjWrl #chembiol
Laura Edgington-Mitchell retweeted
Following #ASCO25, CEO @JSantini1 spoke with ONCOLife to discuss how abenacianine (VGT-309) is shining a light on #lungcancersurgery.
▶️ Watch: bit.ly/44M9vJv
#Innovation #OncologyInnovation #Biotech #ThoracicSurgery
Congrats to Anna and Marc for the publication of their review article "Nuclear Roles for Canonically Lysosomal Proteases.' Check it here: tandfonline.com/doi/full/10.… #LEMLab
Laura Edgington-Mitchell retweeted
The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.
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Laura Edgington-Mitchell retweeted
#News: Phase 2B VISUALIZE study results will be presented by @PennMedicine’s Dr. Sunil Singhal at #ASCO25, demonstrating that intraoperative molecular imaging with abenacianine for injection (VGT-309) during lung surgery has the potential to improve surgical outcomes.
More: bit.ly/439aILt
We have travel awards available for early career researchers, and we are seeking nominations for the Ulrich auf dem Keller Young Investigator award for researchers within 6 years of establishing their independent labs. Please apply before June 30 so you don't miss out!
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Travel: protease.org/travel-awards
Young Investigator: protease.org/young-investiga…
Register for the meeting and workshop: ipsbrazil.com.br/
Apply for IPS membership: protease.org/membership
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Laura Edgington-Mitchell retweeted
In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe, rapidly progressing genetic disease... all in an astounding 7 months. Best of all, the infant patient shows apparent benefit. Congratulations to @kiranmusunuru, Rebecca Ahrens-Nicklas, and other team members for this heroic and inspiring effort, which has implications for the hundreds of millions of patients that suffer from thousands of genetic diseases.
drive.google.com/file/d/1Jfk…
Laura Edgington-Mitchell retweeted
We also show that Coxiella incites the extracellular secretion of lysosomal content in a T4SS-independent manner.
A wonderfully enjoyable collaboration with @LauraEM_Lab & @hayleyjnewton labs (with significant mass spec guidance from @Nick_E_Scott!)
@TheDohertyInst @UniMelbMDHS
Laura Edgington-Mitchell retweeted
Excited to share this story from my PhD, out today in
@NatureComms. We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB.
nature.com/articles/s41467-0…
Laura Edgington-Mitchell retweeted
We’re thrilled to welcome our 14th Snow Fellow, Dr Alisa Glukhova @gl_alisa, a structural biologist from @WEHI_research. Alisa’s work focusses on how cells communicate and what happens when those signals go wrong, leading to diseases like cancer.
snowmedical.org.au
Laura Edgington-Mitchell retweeted
Incredibly excited to share Dr Alisa Glukhova has been awarded a prestigious @SnowMedical Fellowship - the only recipient this year!
She'll receive $8M over 8 years to advance her groundbreaking #cancer research. Congrats @gl_alisa
#medicalresearch
🔗 wehi.edu.au/news/wehi-cancer…
Laura Edgington-Mitchell retweeted
Prof. Matthew Boygo, expert in chemical proteomics, to give plenary talk at MCCB 2025! Don't miss this chance to learn from a visionary.
🔗 bit.ly/4hb6pEl
#RACI #ozchem #BOD1640
I am happy to share a another manuscript by @BangyanXu, a fun collaboration with Simon and @Thompson_Chem. We report some new sulfoxonium ylide activity-based probes for cysteine cathepsins. Check it out! pubs.acs.org/doi/10.1021/acs…
It's been a big week for this proud supervisor. I am so pleased to announce that @alex_ziegler8 has been awarded the Bill Sawyer Medal, which recognises outstanding achievements of Graduate Researchers in the Dept of Biochem & Pharm. Alex has had a great year and is so deserving!
Super proud of Francesca for delivering an excellent final presentation about her 3rd year project in the #LEMLab. Her actual N-terminomics data matched the quality of her cake! Quite a feat!
Laura Edgington-Mitchell retweeted
We are hiring!
Join @VerdoesLab at the @LUMC_Leiden Immunology department to apply chemistry to pioneer the next generation cancer vaccines:
linkedin.com/posts/oncode-ac…
Happy to share the latest from #LEMLab's @alex_ziegler8 and @bethandersonau in collab with @RLatorre_Dr, @Nick_E_Scott and @dufourlab. We show that legumain is activated during colitis and identify protease substrates in naive and inflamed colon. doi.org/10.1002/jcp.31466
