Working toward understanding how we can keep our mitochondria fit and healthy. Co-founder: Automera Also here: @lazaroulab.bsky.social
Joined February 2021
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Michael Lazarou retweeted
Structural biologists- join us to work on the mechanisms of protein transport to mitochondria!
We work in the interdysciplinary group and in collaboration with structural groups.
!Structural friends please distribute! 😊
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Michael Lazarou retweeted
This paper is a stark reminder for why it is so important to innovate in drug discovery against neurodegenerative diseases now. @MTI_UCB
nature.com/articles/s41591-0…
Michael Lazarou retweeted
Excited that our review: "Exercise as Mitochondrial Medicine: How Does the Exercise Prescription Affect Mitochondrial Adaptations to Training?" will soon be published in ANNUAL REVIEW OF PHYSIOLOGY with @MitoPsychoBio & @matt_lee1
Michael Lazarou retweeted
Looking for reviewers before Christmas
nitter.cf/Arezurose/status/18423…
Michael Lazarou retweeted
NEW #Preprint on #ATG8 specialization in #autophagy in #plants: biorxiv.org/content/10.1101/… A short 🧵
Michael Lazarou retweeted
📢📢New work from Dr Linh Dang in my group - analysis of physiological human autophagic flux in leukocytes. Surprises related to ageing, sex effects, and nutrient sensing! @sahmriAU #autophagy #aging
Cell-type specific autophagy in human leukocytes biorxiv.org/content/10.1101/…
Michael Lazarou retweeted
Excited to reveal specific reactive oxygen species as sentinel molecules that control localized protein degradation at #mitochondria to adjust the electron transport chain, with many implications for ROS in development and disease. @UCBerkeley @MTI_UCB
cell.com/molecular-cell/full…
Michael Lazarou retweeted
Excited to share our latest preprint on @biorxivpreprint: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".
biorxiv.org/content/10.1101/…
Michael Lazarou retweeted
Did we conceive the structure of neurons incorrectly all these years?
nature.com/articles/s41593-0… @NatureNeuro
not smooth, cylindrical strands but a string of pearls?
it's controversial
science.org/content/article/… @NewsfromScience @ScienceMagazine
Michael Lazarou retweeted
It was great to have nearly 120 scientists gather for 20th anniversary @BiochemSoc @ASAP_Research meeting in London to mark discovery of #PINK1 mutations in Parkinson's patients by Nick Wood @MDC_IoN_UCL @UCLBrainScience in 2004. 🙏also to @CureParkinsonsT @ParkinsonUK
Michael Lazarou retweeted
We have a PhD position available to study neuronal functions of autophagy and endocytosis.
Michael Lazarou retweeted
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui @Chen3dem using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ @G__Napolitano, A. Esposito, and A. Ballabio.
Michael Lazarou retweeted
New paper out! #AMPK regulates #ULK1 to balance #mitophagy of functional vs dysfunctional mitochondria in @MolecularCell. Great work from authors, especially Marianna Longo @AnikethBishnu and collaborators @Kei_Sakamoto @CarolMacKintos1. See it here: tinyurl.com/AMPK-ULK
Michael Lazarou retweeted
At age 47 Sheenagh was diagnosed with Parkinson’s disease. There is no cure, yet.
Your donation today can accelerate life-saving medical research for Parkinson’s disease and other debilitating conditions.
wehi.edu.au/support-us/donat…
#Parkinsons #YouAreTheCure
Michael Lazarou retweeted
Super happy to see my PhD work with @martens_sascha out in @embojournal. A big thanks to everyone involved and also to @EMBOPress for the smooth revision process!
#Autophagy #MaxPerutzLabs #VBC
For more infos see the paper & my previous tweetorial:
embopress.org/doi/full/10.10…
Michael Lazarou retweeted
Our #ParkinsonDisease research goes beyond the lab, with patients and their loved ones, providing new perspectives that could transform how we understand and approach the disease.
Together, our discoveries are paving the way to healthier futures.
wehi.edu.au/research/clinica…
Michael Lazarou retweeted
#BlogAlert have you read our last Blog entry? Yes...it's true...we have Prof. Yoshinori Ohsumi explaining about his research...#DoNOTmissIT #NobelPrize @NobelPrize
⬇️⬇️⬇️here more: womeninautophagy.com/post/in…
@SEBBM_es @SEFAGIA_ @FEBSnews @NatureCellBio @NatureAging
Michael Lazarou retweeted
Takami Sho, Li Yu et al. @Tsinghua_Uni unveil migratory autolysosome disposal, a response to #lysosome damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring #autophagy machinery, SNARE proteins, and cell #migration. hubs.la/Q02Rwbhg0
Michael Lazarou retweeted
Happy to report this work by the @kalle_gehring lab, led by Véronique Sauvé in collaboration with @biogen, my own lab, and the Fon lab at the @TheNeuro_MNI, on the mechanism of parkin activation by a molecular glue. nature.com/articles/s41467-0…