Developing #EV #exosome therapeutics for #AMD #DiabeticR #RDegeneration @USCEye Lead by Sun Young Lee, MD, PhD.
Los Angeles, CA
Joined June 2023
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LeeRetinaLab@USC retweeted
Are you planning a PhD in neuroscience?
The Department of Neurobiology at USC has launched a new PhD program, and we’re recruiting our first cohort.
Our labs seek answers to:
How animals learn, remember, and choose what to do.
How synapses transmit signals and stay stable over a lifetime.
How neural circuits are built, how they fail in disease, and can they be repaired?
How the brain turns sensation into action.
We investigate these questions at scales from single synapses to whole-brain networks, using molecular, genetic, physiological, imaging, computational, and behavioral approaches across model systems.
Explore our labs: dornsife.usc.edu/neurobiolog…
What you’ll get:
Full funding: tuition plus a $43,000 annual stipend and health insurance
A small cohort with direct faculty mentorship, where you’ll help shape a program as it grows
Lab rotations across three faculty labs before you choose your thesis lab
Los Angeles: a major research hub with S-tier climate, cultural vibrancy and global influence
Applications due December 1, 2026. GRE optional. Application fee waivers available based on demonstrated need.
Apply here: dornsife.usc.edu/neurobiolog…
Any questions? Reply or DM and I’m happy to answer.
LeeRetinaLab@USC retweeted
An eye on extracellular vesicles: Trends and clinical translations in vision research
ow.ly/WSXp50TlZfj
@LeeRetinaLab @USCEye
#ophthalmology
LeeRetinaLab@USC retweeted
Retinal ganglion cell circuits and glial interactions in humans and mice: cell.com/trends/neuroscience…
"This review details which RGC and glial features are conserved between mice, humans, and primates, and which differ."
LeeRetinaLab@USC retweeted
🆕New in #JEV🆕Biopotency and surrogate assays to validate the immunomodulatory potency of extracellular vesicles derived from mesenchymal stem/stromal cells for the treatment of experimental autoimmune uveitis. isevjournals.onlinelibrary.w…
LeeRetinaLab@USC retweeted
How can we bring #EVs to patients safely, effectively and quickly? An in-person #ISEVTaskForce Training Session is underway in #Leuven #Belgium: Regulatory affairs and clinical uses of #ExtracellularVesicles
@IsevOrg @IsevComms
#ectosomes #exosomes
LeeRetinaLab@USC retweeted
AI Igniting Discovery in Medicine ⚡️
We are harnessing AI to turn big data into knowledge, igniting discoveries to solve the toughest health care problems. @DeanMeltzer & @USC SVP Steven Shapiro discuss how to deliver on that promise and minimize risks. keck.usc.edu/AI
LeeRetinaLab@USC retweeted
Dr. Sun Young Lee accepted into the Emerging Vision Scientist Program in Washington D.C. @LeeRetinaLab @RPB_org
LeeRetinaLab@USC retweeted
Today, some colleagues from California and I advocated for eye and vision research at the US Congress. We thank @SenFeinstein, @SenAlexPadilla, Rep @tedlieu, and their teams for meeting with us. Thank you also to @NAEVRAdvocacy for organizing this event. #EVSDay #science – at Capitol Hill, Washington
LeeRetinaLab@USC retweeted
Congrats to Dr. Mark Humayun and @USC-supported startup Regenerative Patch Technologies on their $12.4 grant from @CIRMnews.
research.usc.edu/news/2023/0…
LeeRetinaLab@USC retweeted
Cool new paper showing that human mitochondria internalize (endocytosis-style!) lysosomes during hypoxia. Great EM work and live-cell imaging.
nature.com/articles/s41467-0…
LeeRetinaLab@USC retweeted
Here's a look at the current approaches and challenges facing regenerative medicine: scim.ag/3mh #SciencePerspective
LeeRetinaLab@USC retweeted
Happy to share our publication on Fiji-Assisted Automatic Quantitative Volumetric Analysis of Choroidal Neovascularization in a Laser-Induced Choroidal Neovascularization Mouse Model in TVST @ARVOtvst
tvst.arvojournals.org/articl…
@LeeRetinaLab @USCEye @KeckMedUSC
LeeRetinaLab@USC retweeted
We combined ultrafiltration with washes with TWEEN-20 to isolate extracellular vesicles from conditioned media for proteomics and functional studies. A first step towards high-throughput EV analysis from clinical samples! Reading at biorxiv.org/content/10.1101/….
LeeRetinaLab@USC retweeted
Eisai and Biogen's drug, sold under the brand name Leqembi, is the first amyloid-targeting medication to pass the FDA's full review. usatoday.com/story/news/heal…
LeeRetinaLab@USC retweeted
Congratulations to RPB grantee Dr. Steven DeVries @NUFeinbergMed on the publication of a new study in Nature Communications that uncovers novel cellular mechanisms within the retina helping to advance development of targeted therapeutics. Learn more here: bit.ly/3qWPkIO
LeeRetinaLab@USC retweeted
Our STEM CELL ZOO paper is out in @CellStemCell!
By using in vitro differentiation of ES/iPS cells, we recapitulated the segmentation clocks of mouse, human, rabbit, cow, marmoset, and even rhinoceros🐁🧍♀️🐰🐄🐒🦏
They showed species-specific clock periods!
dlvr.it/SqykTL
LeeRetinaLab@USC retweeted
Cells can pass proteins and RNA to each other through tubes that act as a channel between their membranes. elifesciences.org/articles/8…
LeeRetinaLab@USC retweeted
Parasites can use extracellular vesicles and cellular projections called cytonemes to communicate with one another. elifesciences.org/articles/8…
LeeRetinaLab@USC retweeted
Hippocampal CA1 Neurons are pretty!
Staining: neuron (MAP2-green), astrocyte (GFAP-purple), microglia (iba1-blue) #microscopy #neuroscience
LeeRetinaLab@USC retweeted
"I was late learning about science; I didn’t even know what research was until I was 20 years old. For much of my scientific training I feared I was behind my peers.
But I have been able to close the gap—and that is something to be proud of." scim.ag/332
