Poh Luting (@LutingPoh) profile picture

Poh Luting

@LutingPoh

PhD student working on Vascular Dementia

Joined August 2020
  • Tweets29
  • Following6
  • Followers5
Congrats @LutingPoh for an excellent review
Thiruma V Arumugam (@garriearumugam) profile pictureThiruma V Arumugam@garriearumugam9 Jan 2022
Our latest review article provides a comprehensive insight into the molecular and cellular mechanisms involved in the pathogenesis of Chronic Cerebral Hypoperfusion (CCH)-induced inflammasome signaling in Vascular Cognitive Impairment (VCI). molecularneurodegeneration.b…
The role of inflammasomes in vascular cognitive impairment

The role of inflammasomes in vascular cognitive impairment

Molecular Neurodegeneration - There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays...

link.springer.com
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The capstone of @joycejoy22 PhD with @NUSMedicine is a great review not only of the recent advances in blood biomarkers for AD but also of the technology behind the high sensitivity. Everything you wanted to know about techniques but were afraid to ask! jnnp.bmj.com/content/early/2…
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Glad that together with @HilalSaima @CamStroke @ISD_Research @DondersInst et al, we have established the OPtimising mulTImodal MRI markers for trials of Vascular Cognitive Impairment due to cerebrAl small vesseL disease collaboration and its 1st paper pubmed.ncbi.nlm.nih.gov/3450…
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Another excellent paper from @LutingPoh and @garriearumugam on how hypoperfusion activates the inflammasome even in the cerebellum pubmed.ncbi.nlm.nih.gov/3447…
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Our Healthy Longevity programme featured by @NUSMedicine. Thanks for highlighting the SINGER multiple lifestyle intervention study! medicine.nus.edu.sg/newslett…
Living Better, Longer: How Research Is Giving New Life to Ageing - NUS Medicine

Living Better, Longer: How Research Is Giving New Life to Ageing - NUS Medicine

When I was younger, I thought the term “ageing gracefully” had a nice ring to it. I rather liked the idea of someone describing the 70-year-old me this way as I sipped chamomile tea and knitted a...

medicine.nus.edu.sg
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Congratulations on emphasising the close links between brain health and heart health
Bibek Gyanwali (@bibek_BG) profile pictureBibek Gyanwali@bibek_BG16 Jul 2021
In this study @AgingMacc @HilalSaima we showed the association of blood-based cardiac biomarkers (NT-proBNP, hs-cTnT, and GDF-15) with cognitive decline, incident cerebrovascular disease, vascular events and mortality over the follow-up of 3 years in a memory clinic population.
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So stunned by this incredible illustration of our work at the @ARUK_ODDI on NLRP3 inhibitors as Alzheimer's Disease drugs. Thank you to @JackBrougham for the illustration and the ECR funding awarded by @ARUKThamesV. #NLRP3 #DrugDiscovery @ARUKscientist #AlzheimersResearch #ECR
Image from Grace Gregory (@GraceGregory_)
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Excellent paper on how Sydenham was right to observe that we are as old as our arteries
Angela Jefferson (@AJtheScientist) profile pictureAngela Jefferson@AJtheScientist4 Jul 2021
Our new paper published in @GreenJournal examines the neuropathology correlates of aortic stiffening (bit.ly/3fUBn4Z) - a necessary step in understanding how vascular disease affects the brain and #Alzheimers disease. Takeaways below. @VUMCNeurology @VandyAlz (1/8)
Image from Angela Jefferson (@AJtheScientist)
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From finger to singer : establishing a global evidence base for multiple lifestyle interventions
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Well done @LutingPoh and @garriearumugam for showing that Intermittent Fasting attenuates the inflammatory response and cell death pathways in the brain following chronic hypoperfusion in a mouse model of vascular cognitive impairment (VCI). sciencedirect.com/science/ar…!
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Blood Phosphorylated Tau181, Neurofilament Light Chain, and Neurodegeneration in Alzheimer Disease jamanetwork.com/journals/jam…
Blood Phosphorylated Tau181, Neurofilament Light Chain, and Neurodegeneration in Alzheimer Disease

Blood Phosphorylated Tau181, Neurofilament Light Chain, and Neurodegeneration in Alzheimer Disease

This cohort study uses data from the Alzheimer’s Disease Neuroimaging Initiative study to investigate if blood-based biomarkers can be used to monitor the progression of Alzheimer disease neurodege...

jamanetwork.com
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I am very happy to be part of this excellent work published in Science Advances. Our data establish the influence of O-GlcNAcylation on Aβ accumulation and neurodegeneration, suggesting O-GlcNAcylation–based treatments as potential interventions for AD. advances.sciencemag.org/cont…
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Pushing the boundaries further
Stroke AHA/ASA (@StrokeAHA_ASA) profile pictureStroke AHA/ASA@StrokeAHA_ASA8 Feb 2021
Clinical Relevance of Cortical Cerebral Microinfarcts on 1.5T Magnetic Resonance Imaging in the Late-Adult Population by @HilalSaima et al #MRI #stroke ow.ly/ID2Y50DuvPA
Image from Stroke AHA/ASA (@StrokeAHA_ASA)
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congratulations to @YuekLing_Chai for her work on circulating osteopontin, a marker for inflammation, as a biomarker for cognitive impairment and dementia as well as MRI changes pubmed.ncbi.nlm.nih.gov/3359…
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Excellent first paper by masters student Mervyn Lim supervised by @HilalSaima on the effect of intracranial stenosis on executive function over time pubmed.ncbi.nlm.nih.gov/3363…
The effect of intracranial stenosis on cognitive decline in a memory clinic cohort - PubMed

The effect of intracranial stenosis on cognitive decline in a memory clinic cohort - PubMed

Intracranial stenosis was independently associated with worse executive function across all time points, and cognitive decline in memory and visuomotor speed over 3 years of follow-up. This suggests...

pubmed.ncbi.nlm.nih.gov
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Another important consequence of cortical cerebral microinfarcts which are associated with incidence and progression of geriatric neurobehavioral disturbances, independent of conventional SVD markers. pubmed.ncbi.nlm.nih.gov/3372…
Long-term neurobehavioral correlates of brain cortical microinfarcts in a memory clinic cohort in...

Long-term neurobehavioral correlates of brain cortical microinfarcts in a memory clinic cohort in...

Cortical cerebral microinfarcts are associated with incidence and progression of geriatric neurobehavioral disturbances, independent of conventional small vessel disease markers. The impact of...

pubmed.ncbi.nlm.nih.gov
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Great paper by @joycejoy22 with @NicholasAshton @TommyKakari and colleagues in Gothenburg on how useful blood biomarkers are in Asians with cognitive impairment and dementia pubmed.ncbi.nlm.nih.gov/3379…
Plasma P-tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an...

Plasma P-tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an...

Plasma P-tau181/Aβ42 ratio may be a noninvasive means of identifying AD with elevated brain amyloid in populations with concomitant CeVD.

pubmed.ncbi.nlm.nih.gov
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Our work on amyloid pet is featured by @NUSMedicine
Image from Memory Aging & Cognition Centre (MACC) Singapore (@AgingMacc)
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Grateful to our Singaporean and regional colleagues, in particular the late and much missed simeon marasigan, for conducting this clinical trial in post stroke cognitive impairment pubmed.ncbi.nlm.nih.gov/3381…
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Please let us know what you think of the beta version of our new website macc.sg/Memory-Aging-and-Cog…
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